Sosioeconomic, Behavioral, and Biological Determinants of Tuberculosis Incidence: A Case Study in Aceh Besar, Indonesia
Abstract
Introduction: Tuberculosis (TB) pandemic is a significant global health concern, especially in low- and middle-income countries. Every year the incidence and deaths due to TB continue to increase. Preventing and controlling TB effectively requires understanding the complex interplay of the multidimensional TB risk factors, which consist of social, behavioral, and biological determinants that contribute to its spread. This study aimed to identify and analyze the primary risk factors associated with TB incidence.
Methods: This study employed a case-control design with 44 respondents consisting of 22 laboratory-confirmed TB patients and 22 non-TB patients with matching ages and sex. This study used a structured questionnaire was used to collect data through face-to-face interviews. The questionnaire assessed risk factors across three key domains: social determinants, behavioral determinants, and biological determinants. Bivariate analysis, which used a chi-square test (p-value <0.05), and multivariate analysis, which used a logistic regression test, were performed to determine risk factors most associated with TB incidence.
Results: Low income (p-value=0.015;OR=6.923;95%CI=1.285-37.287), high TB-related stigma (p-value=0.033;OR=3.852;95%CI=1.086-13.661), insufficient TB knowledge (p-value =0.033;OR=3.852;95%CI=1.086-13.661), food insecurity (p-value=0.006;OR=5.950;95%CI=1.586-22.328), lack of preventative measures (p-value=0.015;OR=4.667;95%CI=1.299-16.761), history of contact with TB patients (p-value =0.039;OR=7.875;95%CI=0.860-72.122), and presence of comorbidities (p-value =0.031;OR=5.714;95%CI=1.051-31.072) were significantly associated with TB incidence. Comorbidities emerged as the strongest risk factor (p-value =0.020; OR=12.141;95%CI=1.486-99.231).
Conclusion: This study highlights several major factors influencing TB incidence, including social, behavioral, and biological determinants. The findings suggest that effective TB control strategies should address socioeconomic conditions, promote healthy lifestyles, and involve community leaders and TB survivors in educational campaigns, stigma reduction, and early diagnosis efforts. Understanding these health determinants can inform more targeted public policies for curbing TB incidence.
References
World Health Organization (WHO). Global Tuberculosis Report 2023. 2023; [accessed 19 Jun 2024] Available from: https://iris.who.int/.
Bai W, Ameyaw EK. Global, regional and national trends in tuberculosis incidence and main risk factors: a study using data from 2000 to 2021. BMC Public Health. 2024 Dec 1;24(1):1–14. [accessed 19 Jun 2024] Available from: https://bmcpublichealth.biomedcentral.com/articles/10.1186/s12889-023-17495-6
World Health Organization (WHO). Global Tuberculosis Report 2022. 2022. [accessed 10 Sep 2023] Available from: https://www.who.int/publications/i/item/9789240061729
Gupta K, Gupta R, Atreja A, Verma M, Vishvkarma S. Tuberculosis and nutrition. Lung India. 2009 Jan 1;26(1):9–16. [accessed 12 May 2022] Available from: https://pubmed.ncbi.nlm.nih.gov/20165588/
Erlinger S, Stracker N, Hanrahan C, Nonyane BAS, Mmolawa L, Tampi R, et al. Tuberculosis patients with higher levels of poverty face equal or greater costs of illness. Int J Tuberc Lung Dis. 2019 Nov 1;23(11):1205–12. [accessed 22 Oct 2022] Available from: https://pubmed.ncbi.nlm.nih.gov/31718757/
Vesga JF, Hallett TB, Reid MJA, Sachdeva KS, Rao R, Khaparde S, et al. Assessing tuberculosis control priorities in high-burden settings: a modelling approach. Lancet Glob Heal. 2019 May 1;7(5):e585–95. doi: 10.1016/S2214-109X(19)30037-3
Kemenkes RI. Laporan Kinerja Direktorat Jenderal Pencegahan dan Pengendalian Penyakit Tahun 2023. Jakarta; 2023.
Ditjen P2P Kemenkes. Profil Kesehatan Indonesia Tahun 2022. 2023. [accessed 27 Feb 2024] Available from: https://p2p.kemkes.go.id/profil-kesehatan-2022/
Junaid SA, Kanma-Okafor OJ, Olufunlayo TF, Odugbemi BA, Ozoh OB. Tuberculosis stigma: Assessing tuberculosis knowledge, attitude and preventive practices in surulere, Lagos, Nigeria. Ann Afr Med. 2021 Jul 1;20(3):184–92. [accessed 10 Nov 2023] Available from: https://pubmed.ncbi.nlm.nih.gov/34558447/
Silva DR, Muñoz-Torrico M, Duarte R, Galvão T, Bonini EH, Arbex FF, et al. Risk factors for tuberculosis: diabetes, smoking, alcohol use, and the use of other drugs. J Bras Pneumol. 2018 Mar 1;44(2):145. [accessed 12 May 2022] Available from: /pmc/articles/PMC6044656/
Dinas Kesehatan Provinsi Aceh. Profil Kesehatan Aceh Tahun 2022. 2023. [accessed 4 Nov 2023] Available from: https://dinkes.acehprov.go.id/detailpost/profil-kesehatan-aceh-tahun-2022
Souza Filho JB de O e., Sanchez M, Seixas JM de, Maidantchik C, Galliez R, Moreira A da SR, et al. Screening for active pulmonary tuberculosis: Development and applicability of artificial neural network models. Tuberculosis. 2018 Jul 1;111:94–101. doi: 10.1016/J.TUBE.2018.05.012
Lin HH, Wang L, Zhang H, Ruan Y, Chin DP, Dye C. Tuberculosis control in China: use of modelling to develop targets and policies. Bull World Health Organ. 2015 Nov 1;93(11):790–8. [accessed 26 Oct 2022] Available from: https://pubmed.ncbi.nlm.nih.gov/26549907/
Flores GP, Alberto IRI, Eala MAB, Cañal JPA. The social determinants of tuberculosis in the Philippines. Lancet Glob Heal. 2022 Jan 1;10(1):e38. [accessed 5 Jan 2022] Available from: https://linkinghub.elsevier.com/retrieve/pii/S2214109X21005167
Hassen J, Gizaw A, Mohamed S. Determinants of pulmonary tuberculosis in public health facilities of Dire Dawa City, Eastern Ethiopia: Unmatched Case-control study. Int J mycobacteriology. 2019 Apr 1;8(2):118–23. [accessed 3 Jan 2022] Available from: https://pubmed.ncbi.nlm.nih.gov/31210152/
Kepres RI. Undang-undang (UU) Nomor 20 Tahun 2003 tentang Sistem Pendidikan Nasional. 2003. [accessed 25 Jun 2024] Available from: https://peraturan.bpk.go.id/Details/43920/uu-no-20-tahun-2003
Biro Administrasi Setda Aceh. Upah Minimum Provinsi Aceh. 2022. [accessed 14 Jun 2024] Available from: https://humas.acehprov.go.id/upah-minimum-provinsi-aceh-tahun-2023-rp-3-413-66-naik-78-persen/
Vericat-Ferrer M, Ayala A, Ncogo P, Eyene-Acuresila J, García B, Benito A, et al. Knowledge, Attitudes, and Stigma: The Perceptions of Tuberculosis in Equatorial Guinea. Int J Environ Res Public Health. 2022 Jul 1;19(14). [accessed 10 Nov 2023] Available from: https://pubmed.ncbi.nlm.nih.gov/35886079/
Susilaningrum D, Ulama BSS, Wulandari SP, Salamah M. The analysis of factors that affecting household food security of tuberculosis patients in Surabaya. J Phys Conf Ser. 2019 Nov 7;1341(9). doi: 10.1088/1742-6596/1341/9/092014
Puspitasari IM, Sinuraya RK, Aminudin AN, Kamilah RR. Knowledge, Attitudes, and Preventative Behavior Toward Tuberculosis in University Students in Indonesia. Infect Drug Resist. 2022;15:4721. [accessed 1 Nov 2023] Available from: /pmc/articles/PMC9416452/
Alavi-Naini R, Sharifi-Mood B, Metanat M. Association Between Tuberculosis and Smoking. Int J High Risk Behav Addict. 2012 Jul 25;1(2):71. [accessed 20 Jun 2024] Available from: /pmc/articles/PMC4070106/
Shamaei M, Esmaeili S, Marjani M, Tabarsi P. Implementing Tuberculosis Close-contact Investigation in a Tertiary Hospital in Iran. Int J Prev Med. 2018 May 1;9. [accessed 13 May 2022] Available from: https://pubmed.ncbi.nlm.nih.gov/29899886/
Bates M, Marais BJ, Zumla A. Tuberculosis Comorbidity with Communicable and Noncommunicable Diseases. Cold Spring Harb Perspect Med. 2015 Nov 1;5(11). [accessed 12 May 2022] Available from: /pmc/articles/PMC4632868/
Djibuti M, Mirvelashvili E, Makharashvili N, Magee MJ. Household income and poor treatment outcome among patients with tuberculosis in Georgia: a cohort study. BMC Public Health. 2014 Jan 29;14(1). [accessed 7 Apr 2022] Available from: https://pubmed.ncbi.nlm.nih.gov/24476154/
Su Y, Garcia Baena I, Harle AC, Crosby SW, Micah AE, Siroka A, et al. Tracking total spending on tuberculosis by source and function in 135 low-income and middle-income countries, 2000–17: a financial modelling study. Lancet Infect Dis. 2020 Aug 1;20(8):929–42. doi: 10.1016/S1473-3099(20)30124-9
Shaji B, Arun Thomas ET, Sasidharan PK. Tuberculosis control in India: Refocus on nutrition. Indian J Tuberc. 2019 Jan 1;66(1):26–9. [accessed 16 May 2022] Available from: https://pubmed.ncbi.nlm.nih.gov/30797277/
Da Silva V. TS. WN. & BM. The Relationship Between Education, Job, and Family Income with TB Medication Dropouts in Timor-Leste. Bali Med J. 2016;5(2):279–82. [accessed 20 Jun 2024] Available from: https://balimedicaljournal.org/index.php/bmj/article/view/223/pdf_112
Echazarreta A, Zerbini E, De Sandro J, Sáenz C, Yessi L, Saad R, et al. Tuberculosis and comorbidities in urban areas in Argentina. A gender and age perspective. Biomedica. 2018;38(2):180–8. [accessed 2 Aug 2022] Available from: https://pubmed.ncbi.nlm.nih.gov/30184347/
Clark M, Riben P, Nowgesic E. The association of housing density, isolation and tuberculosis in Canadian First Nations communities. Int J Epidemiol. 2002;31(5):940–5. [accessed 6 Jan 2024] Available from: https://pubmed.ncbi.nlm.nih.gov/12435764/
Amaliah L, Rufaedah AA, Nurcahyati S, Abdurakhman RN, Hidayat A, Amaliah L, et al. The relationship between the physical home environment and the event of tuberculosis. https://wjarr.com/sites/default/files/WJARR-2022-0627.pdf. 2022 Jun 30;14(3):623–8. [accessed 5 Jan 2024] Available from: https://wjarr.com/content/relationship-between-physical-home-environment-and-event-tuberculosis
Oktaria S, Hurif NS, Naim W, Thio HB, Nijsten TEC, Richardus JH. Dietary diversity and poverty as risk factors for leprosy in Indonesia: A case-control study. PLoS Negl Trop Dis. 2018 Mar 13;12(3). [accessed 19 Jun 2024] Available from: https://pubmed.ncbi.nlm.nih.gov/29534113/
Mohidem N, Osman M, Muharam F, Elias S, Shaharudin R, Hashim Z. Prediction of tuberculosis cases based on sociodemographic and environmental factors in gombak, Selangor, Malaysia: A comparative assessment of multiple linear regression and artificial neural network models. Int J mycobacteriology. 2021 Oct 1;10(4):442–56. [accessed 26 Oct 2022] Available from: https://pubmed.ncbi.nlm.nih.gov/34916466/
Du CR, Wang SC, Yu MC, Chiu TF, Wang JY, Chuang PC, et al. Effect of ventilation improvement during a tuberculosis outbreak in underventilated university buildings. Indoor Air. 2020 May 1;30(3):422–32. [accessed 13 May 2022] Available from: https://pubmed.ncbi.nlm.nih.gov/31883403/
Mariana D, Hairuddin MC. Kepadatan Hunian, Ventilasi dan Pencahayaan terhadap Kejadian TB Paru di Wilayah Kerja Puskesmas Binanga Kabupaten Mamuju Sulawesi Barat. J Kesehat Manarang. 2018 Jan 16;3(2):75. [accessed 31 Oct 2023] Available from: http://www.jurnal.poltekkesmamuju.ac.id/index.php/m/article/view/40
Gautam N, Karki RR, Khanam R. Knowledge on tuberculosis and utilization of DOTS service by tuberculosis patients in Lalitpur District, Nepal. PLoS One. 2021 Jan 1;16(1). [accessed 8 May 2022] Available from: https://pubmed.ncbi.nlm.nih.gov/33493188/
Zille AI, Werneck GL, Luiz RR, Conde MB. Social determinants of pulmonary tuberculosis in Brazil: An ecological study. BMC Pulm Med. 2019 May 8;19(1):1–9. [accessed 5 Jan 2022] Available from: https://link.springer.com/articles/10.1186/s12890-019-0855-1
Wubuli A, Xue F, Jiang D, Yao X, Upur H, Wushouer Q. Socio-Demographic Predictors and Distribution of Pulmonary Tuberculosis (TB) in Xinjiang, China: A Spatial Analysis. PLoS One. 2015 Dec 1;10(12). [accessed 24 Oct 2022] Available from: https://pubmed.ncbi.nlm.nih.gov/26641642/
Ross JM, Xie Y, Wang Y, Collins JK, Horst C, Doody JB, et al. Estimating the population at high risk for tuberculosis through household exposure in high-incidence countries: a model-based analysis. eClinicalMedicine. 2021 Dec 1;42:101206. doi: 10.1016/J.ECLINM.2021.101206
Khan AA, Akhtar N, Madni A, Tahir N, Rehman M, Raza A, et al. Socio-economic constrains faced by TB patients that lead to non-compliance - A cross sectional study in Southern Punjab, Pakistan. Acta Pol Pharm - Drug Res. 2017;74(3):995–1000.
Rutherford AE, Unruh L. Political, economic, and health system determinants of tuberculosis incidence. J Public Heal. 2019 Oct 1;27(5):541–52. doi: 10.1007/S10389-018-0991-8/TABLES/3
Yates TA, Ayles H, Leacy FP, Schaap A, Boccia D, Beyers N, et al. Socio-economic gradients in prevalent tuberculosis in Zambia and the Western Cape of South Africa. Trop Med Int Health. 2018 Apr 1;23(4):375–90. [accessed 1 Nov 2023] Available from: https://pubmed.ncbi.nlm.nih.gov/29432669/
Oladele DA, Balogun MR, Odeyemi K, Salako BL. A Comparative Study of Knowledge, Attitude, and Determinants of Tuberculosis-Associated Stigma in Rural and Urban Communities of Lagos State, Nigeria. Tuberc Res Treat. 2020 Dec 3;2020:1–14. [accessed 6 Mar 2024] Available from: https://pubmed.ncbi.nlm.nih.gov/33343936/
Craig GM, Daftary A, Engel N, O’Driscoll S, Ioannaki A. Tuberculosis stigma as a social determinant of health: a systematic mapping review of research in low incidence countries. Vol. 56, International Journal of Infectious Diseases. 2017. doi: 10.1016/j.ijid.2016.10.011
Ashaba C, Musoke D, Wafula ST, Konde-Lule J. Stigma among tuberculosis patients and associated factors in urban slum populations in Uganda. Afr Health Sci. 2021;21(4):1640–50. [accessed 27 Dec 2023] Available from: https://pubmed.ncbi.nlm.nih.gov/35283968/
Jing Teo AK, Jin Tan RK, Smyth C, Soltan V, Eng S, Ork C, et al. Characterizing and Measuring Tuberculosis Stigma in the Community: A Mixed-Methods Study in Cambodia. Open Forum Infect Dis. 2020 Oct 1;7(10). [accessed 6 Mar 2024] Available from: https://dx.doi.org/10.1093/ofid/ofaa422
Chen X, Du L, Wu R, Xu J, Ji H, Zhang Y, et al. Tuberculosis-related stigma and its determinants in Dalian, Northeast China: a cross-sectional study. BMC Public Health. 2021 Dec 1;21(1):1–10. [accessed 5 Jan 2022] Available from: https://link.springer.com/articles/10.1186/s12889-020-10055-2
Abebe G, Deribew A, Apers L, Woldemichael K, Shiffa J, Tesfaye M, et al. Knowledge, health seeking behavior and perceived stigma towards tuberculosis among tuberculosis suspects in a rural community in southwest Ethiopia. PLoS One. 2010;5(10). [accessed 19 Dec 2023] Available from: https://pubmed.ncbi.nlm.nih.gov/20948963/
Fitri S, Tahlil T, Susanti SS. Stigma in Tuberculosis Sufferers: A Study in Simeulue Regency, Aceh Indonesia. Int J Nurs Educ. 2022 Apr 13;14(2):199–208. [accessed 17 May 2022] Available from: https://medicopublication.com/index.php/ijone/article/view/18021
Jing Teo AK, Jin Tan RK, Smyth C, Soltan V, Eng S, Ork C, et al. Characterizing and Measuring Tuberculosis Stigma in the Community: A Mixed-Methods Study in Cambodia. Open forum Infect Dis. 2020 Oct 1;7(10). [accessed 10 Nov 2023] Available from: https://pubmed.ncbi.nlm.nih.gov/33134412/
Smith A, Herington E, Loshak H. Tuberculosis Stigma and Racism, Colonialism, and Migration: A Rapid Qualitative Review. Tuberc Stigma Racism, Colon Migr A Rapid Qual Rev. 2021; [accessed 27 Dec 2023] Available from: https://www.ncbi.nlm.nih.gov/books/NBK571944/
Courtwright A, Turner AN. Tuberculosis and Stigmatization: Pathways and Interventions. Public Health Rep. 2010;125(Suppl 4):34. [accessed 17 May 2022] Available from: /pmc/articles/PMC2882973/
Oladele DA, Idigbe IE, Ekama SO, Gbajabiamila T, Ohihoin AG, David AN, et al. ‘Their place is beyond the town’s border’: A qualitative exploration of stigma associated with tuberculosis in rural and urban areas of Lagos, Nigeria. Health Soc Care Community. 2021 Nov 1;29(6):1789–98. [accessed 6 Mar 2024] Available from: https://pubmed.ncbi.nlm.nih.gov/33491866/
Suleiman, Sahal, Sodemann, A Elsony A. Tuberculosis awareness in Gezira, Sudan: knowledge, attitude and practice case-control survey. East Mediterr Heal J . 2014;20(2):120–9. [accessed 10 Sep 2023] Available from: https://pubmed.ncbi.nlm.nih.gov/24945561/
Abu-Humaidan AHA, Tarazi A, Hamadneh Y, Al-leimon A, Al-leimon O, Aljahalin M, et al. Knowledge, attitudes, and practices toward tuberculosis among Jordanian university students. Front public Heal. 2022 Nov 21;10. [accessed 10 Sep 2023] Available from: https://pubmed.ncbi.nlm.nih.gov/36478722/
Kwedi Nolna S, Kammogne ID, Ndzinga R, Afanda B, Ntonè R, Boum Y, et al. Community knowledge, attitudes and practices in relation to tuberculosis in Cameroon. Int J Tuberc Lung Dis. 2016 Sep 1;20(9). [accessed 10 Nov 2023] Available from: https://pubmed.ncbi.nlm.nih.gov/27510246/
Nyasulu P, Sikwese S, Chirwa T, Makanjee C, Mmanga M, Babalola JO, et al. Knowledge, beliefs, and perceptions of tuberculosis among community members in Ntcheu district, Malawi. J Multidiscip Healthc. 2018;11:375–89. [accessed 10 Nov 2023] Available from: https://pubmed.ncbi.nlm.nih.gov/30147328/
Ndi NN, Lukong HS, Samje M. Prevalence, knowledge and practices towards tuberculosis prevention in the Bamenda III sub-division, Cameroon. Indian J Tuberc. 2023 Jul 1;70(3). [accessed 10 Nov 2023] Available from: https://pubmed.ncbi.nlm.nih.gov/37562910/
Hassan AO, Olukolade R, Ogbuji QC, Afolabi S, Okwuonye LC, Kusimo OC, et al. Knowledge about Tuberculosis: A Precursor to Effective TB Control—Findings from a Follow-Up National KAP Study on Tuberculosis among Nigerians. Tuberc Res Treat. 2017;2017:1–8. doi: 10.1155/2017/6309092
Mbuthia GW, Olungah CO, Ondicho TG. Knowledge and perceptions of tuberculosis among patients in a pastoralist community in Kenya: a qualitative study. Pan Afr Med J. 2018;30. [accessed 8 May 2022] Available from: https://pubmed.ncbi.nlm.nih.gov/30637071/
Mangesho, Shayo, Makunde, Keto, Mandara, Kamugisha & I. Community knowledge, attitudes and practices towards tuberculosis and its treatment in Mpwapwa district, central Tanzania. Tanzan J Health Res. 2007;9(1):38–43. [accessed 20 Jun 2024] Available from: https://pubmed.ncbi.nlm.nih.gov/17547099/
Badane AA, Dedefo MG, Genamo ES, Bekele NA. Knowledge and Healthcare Seeking Behavior of Tuberculosis Patients attending Gimbi General Hospital, West Ethiopia. Ethiop J Health Sci. 2018 Sep 1;28(5):529. [accessed 19 Dec 2023] Available from: /pmc/articles/PMC6308772/
Kigozi NG, Heunis JC, Engelbrecht MC, Janse Van Rensburg AP, Van Rensburg HCJD. Tuberculosis knowledge, attitudes and practices of patients at primary health care facilities in a South African metropolitan: Research towards improved health education. BMC Public Health. 2017 Oct 10;17(1):1–8. [accessed 12 May 2022] Available from: https://bmcpublichealth.biomedcentral.com/articles/10.1186/s12889-017-4825-3
Islam QS, Islam MA, Islam S, Ahmed SM. Prevention and control of tuberculosis in workplaces: how knowledgeable are the workers in Bangladesh? BMC Public Health. 2015 Dec 24;15(1). [accessed 10 Sep 2023] Available from: https://pubmed.ncbi.nlm.nih.gov/26703074/
Hossain S, Zaman K, Quaiyum A, Banu S, Husain A, Islam A, et al. Factors associated with poor knowledge among adults on tuberculosis in Bangladesh: results from a nationwide survey. J Health Popul Nutr. 2015;34(1). [accessed 10 Sep 2023] Available from: /pmc/articles/PMC5465564/
Food and Agriculture Organization (FAO), AFAD, UNICEF, WFP, WHO. The State of Food Security and Nutrition in the World 2021. The State of Food Security and Nutrition in the World 2021. FAO, IFAD, UNICEF, WFP and WHO; 2021. doi: 10.4060/cb4474en
Susilaningrum D, Ulama BSS, Lathifah R, Susilaningrum D, Ulama BSS, Lathifah R. Mapping the Factors Affecting Household Food Security of Tuberculosis Patients in Coastal Region of Surabaya. MS&E. 2018 Apr 25;335(1):012053. [accessed 16 May 2022] Available from: https://ui.adsabs.harvard.edu/abs/2018MS&E..335a2053S/abstract
Amrith N, Laksiri J, Nayanathara N, Derore IK. Food Security and Nutrition among the Tuberculosis infected patients A case study among the patients screened at Chest Clinic of Medical Research Institute of Colombo, Sri Lanka. 2014.
Lee GO, Paz-Soldan VA, Riley-Powell AR, Gómez A, Tarazona-Meza C, Paliza KV, et al. Food Choice and Dietary Intake among People with Tuberculosis in Peru: Implications for Improving Practice. Curr Dev Nutr. 2020 Feb 1;4(2). [accessed 20 Jun 2024] Available from: https://pubmed.ncbi.nlm.nih.gov/32025614/
International Food Policy Research Institute. Food Security. [accessed 31 Oct 2023] Available from: https://www.ifpri.org/topic/food-security
Carter DJ, Glaziou P, Lönnroth K, Siroka A, Floyd K, Weil D, et al. The impact of social protection and poverty elimination on global tuberculosis incidence: a statistical modelling analysis of Sustainable Development Goal 1. Lancet Glob Heal. 2018 May 1;6(5):e514–22. doi: 10.1016/S2214-109X(18)30195-5
Odone A, Houben RMGJ, White RG, Lönnroth K. The effect of diabetes and undernutrition trends on reaching 2035 global tuberculosis targets. lancet Diabetes Endocrinol. 2014 Sep 1;2(9):754–64. [accessed 27 Oct 2022] Available from: https://pubmed.ncbi.nlm.nih.gov/25194888/
Boccia D, Rudgard W, Shrestha S, Lönnroth K, Eckhoff P, Golub J, et al. Modelling the impact of social protection on tuberculosis: The S-PROTECT project. BMC Public Health. 2018 Jun 26;18(1):1–9. [accessed 5 Jan 2022] Available from: https://link.springer.com/articles/10.1186/s12889-018-5539-x
Nikovska DG, Tozija F. Social determinants of equity in access to healthcare for tuberculosis patients in Republic of Macedonia – results from a case-control study. Int J Heal Policy Manag. 2014;3(4):199. [accessed 20 Jun 2024] Available from: /pmc/articles/PMC4181969/
Valencia-Aguirre S, Arroyave I, García-Basteiro AL. Educational level and tuberculosis mortality in Colombia: growing inequalities and stagnation in reduction. Cad Saude Publica. 2022;38(1). [accessed 31 Oct 2023] Available from: https://pubmed.ncbi.nlm.nih.gov/35107505/
Rubel AJ, Garro LC. Social and cultural factors in the successful control of tuberculosis. Public Health Rep. 1992;107(6):626. [accessed 29 Oct 2022] Available from: /pmc/articles/PMC1403712/?report=abstract
World Health Organization (WHO). Tuberculosis Control. 2014.
Badane AA, Dedefo MG, Genamo ES, Bekele NA. Knowledge and Healthcare Seeking Behavior of Tuberculosis Patients attending Gimbi General Hospital, West Ethiopia. Ethiop J Health Sci. 2018 Sep 1;28(5):529–38. [accessed 27 Dec 2023] Available from: https://pubmed.ncbi.nlm.nih.gov/30607067/
Pai M, Delavallade C, Huddart S, Bossuroy T, Pons V, Baral S. Knowledge about tuberculosis and infection prevention behavior: A nine city longitudinal study from India. PLoS One. 2018 Oct 1;13(10). [accessed 1 Nov 2023] Available from: https://pubmed.ncbi.nlm.nih.gov/30376558/
Li J, Pu J, Liu J, Wang Q, Zhang R, Zhang T, et al. Determinants of self-management behaviors among pulmonary tuberculosis patients: a path analysis. Infect Dis Poverty. 2021 Dec 1;10(1):1–11. [accessed 5 Jan 2022] Available from: https://link.springer.com/articles/10.1186/s40249-021-00888-3
Dartois VA, Rubin EJ. Anti-tuberculosis treatment strategies and drug development: challenges and priorities. Nat Rev Microbiol 2022 2011. 2022 Apr 27;20(11):685–701. [accessed 19 Jun 2024] Available from: https://www.nature.com/articles/s41579-022-00731-y
Setyaningrum R, Zubaidah T, Anhar VY. Correlation between Gender, Age, Education Level, and Working Status with Anti-Tuberculosis Drug Uses (OATS) in Patients with Lung TB in Indonesia 2013. Int J Chem Mater Sci. 2013;1(1):7–13. doi: 10.31295/ijcms.v1n1.3
Taylor JG, Yates TA, Mthethwa M, Tanser F, Abubakar I, Altamirano H. Measuring ventilation and modelling M. tuberculosis transmission in indoor congregate settings, rural KwaZulu-Natal. Int J Tuberc Lung Dis. 2016 Sep 1;20(9). [accessed 26 Oct 2022] Available from: https://pubmed.ncbi.nlm.nih.gov/27510239/
Cain KP, McCarthy KD, Heilig CM, Monkongdee P, Tasaneeyapan T, Kanara N, et al. An algorithm for tuberculosis screening and diagnosis in people with HIV. N Engl J Med. 2010 Feb 25;362(8):707–16. [accessed 20 Jun 2024] Available from: https://pubmed.ncbi.nlm.nih.gov/20181972/
World Health Organization (WHO). Smoking and tuberculosis: a dangerous combination. 2018 Mar 22; [accessed 12 May 2022] Available from: https://www.euro.who.int/en/health-topics/communicable-diseases/tuberculosis/news/news/2018/3/smoking-and-tuberculosis-a-dangerous-combination
World Health Organization. Tuberculosis. 2023. [accessed 10 Nov 2023] Available from: https://www.who.int/news-room/fact-sheets/detail/tuberculosis
Reichler MR, Khan A, Sterling TR, Zhao H, Moran J, McAuley J, et al. Risk and Timing of Tuberculosis Among Close Contacts of Persons with Infectious Tuberculosis. J Infect Dis. 2018 Aug 14;218(6):1000. [accessed 13 May 2022] Available from: /pmc/articles/PMC6534268/
Morrison J, Pai M, Hopewell PC. Tuberculosis and latent tuberculosis infection in close contacts of people with pulmonary tuberculosis in low-income and middle-income countries: a systematic review and meta-analysis. Lancet Infect Dis. 2008 Jun;8(6):359–68. [accessed 20 Jun 2024] Available from: https://pubmed.ncbi.nlm.nih.gov/18450516/
Fox GJ, Nhung N V., Sy DN, Hoa NLP, Anh LTN, Anh NT, et al. Household-Contact Investigation for Detection of Tuberculosis in Vietnam. N Engl J Med. 2018 Jan 18;378(3):221–9. [accessed 24 Oct 2022] Available from: https://pubmed.ncbi.nlm.nih.gov/29342390/
MacPherson P, Lebina L, Motsomi K, Bosch Z, Milovanovic M, Ratsela A, et al. Prevalence and risk factors for latent tuberculosis infection among household contacts of index cases in two South African provinces: Analysis of baseline data from a cluster-randomised trial. PLoS One. 2020;15(3). [accessed 22 Oct 2022] Available from: https://pubmed.ncbi.nlm.nih.gov/32182274/
Martin-Sanchez M, Brugueras S, De Andrés A, Simon P, Gorrindo P, Ros M, et al. Tuberculosis incidence among infected contacts detected through contact tracing of smear-positive patients. PLoS One. 2019 Apr 1;14(4). [accessed 24 Oct 2022] Available from: https://pubmed.ncbi.nlm.nih.gov/30986227/
Yadav RP, Nishikiori N, Satha P, Eang MT, Lubell Y. Cost-effectiveness of a tuberculosis active case finding program targeting household and neighborhood contacts in Cambodia. Am J Trop Med Hyg. 2014;90(5):866–72. [accessed 22 Oct 2022] Available from: https://pubmed.ncbi.nlm.nih.gov/24615134/
Fox GJ, Barry SE, Britton WJ, Marks GB. Contact investigation for tuberculosis: a systematic review and meta-analysis. Available from: www.erj.ersjournals.com
Khatana GH, Masoodi M, Amin M. Factors affecting applicability of “home-based interventional model” for active case finding among household contacts of index cases of pulmonary tuberculosis in Kashmir. Indian J Tuberc. 2017 Jul 1;64(3):189–95. doi: 10.1016/J.IJTB.2017.01.011
Kaswaswa K, MacPherson P, Kumwenda M, Mpunga J, Thindwa D, Nliwasa M, et al. Effect of patient-delivered household contact tracing and prevention for tuberculosis: A household cluster-randomised trial in Malawi. PLoS One. 2022 Sep 1;17(9). [accessed 22 Oct 2022] Available from: https://pubmed.ncbi.nlm.nih.gov/36074775/
Zhou M, Wang L, Li M, Zou J, Li Y, Li J, et al. Contact investigation of tuberculosis in Shanghai, China: A 13-year cohort. Tuberculosis (Edinb). 2023 Mar 1;139. [accessed 4 Jan 2024] Available from: https://pubmed.ncbi.nlm.nih.gov/36805089/
Awad SF, Critchley JA, Abu-Raddad LJ. Epidemiological impact of targeted interventions for people with diabetes mellitus on tuberculosis transmission in India: Modelling based predictions. Epidemics. 2020 Mar 1;30:100381. doi: 10.1016/J.EPIDEM.2019.100381
Mulongeni P, Hermans S, Caldwell J, Bekker LG, Wood R, Kaplan R. HIV prevalence and determinants of loss-to-follow-up in adolescents and young adults with tuberculosis in Cape Town. PLoS One. 2019 Feb 1;14(2). [accessed 3 Jan 2022] Available from: https://pubmed.ncbi.nlm.nih.gov/30721239/
Zafari P, Golpour M, Hafezi N, Bashash D, Esmaeili SA, Tavakolinia N, et al. Tuberculosis comorbidity with rheumatoid arthritis: Gene signatures, associated biomarkers, and screening. IUBMB Life. 2021 Jan 1;73(1):26–39. [accessed 24 Jun 2024] Available from: https://pubmed.ncbi.nlm.nih.gov/33217772/
Lu P, Zhang Y, Liu Q, Ding X, Kong W, Zhu L, et al. Association of BMI, diabetes, and risk of tuberculosis: a population-based prospective cohort. Int J Infect Dis. 2021 Aug 1;109:168–73. [accessed 26 Oct 2022] Available from: https://pubmed.ncbi.nlm.nih.gov/34217872/
Tamura A. Tuberculosis And Lung Cancer. Kekkaku. 2016;91(1):17–25. [accessed 24 Jun 2024] Available from: https://pubmed.ncbi.nlm.nih.gov/27192776/
Moon D, Jeong D, Kang YA, Choi H. Gender differences in tuberculosis patients with comorbidity: A cross-sectional study using national surveillance data and national health insurance claims data in South Korea. PLoS One. 2023 Jan 1;18(1). [accessed 24 Jun 2024] Available from: https://pubmed.ncbi.nlm.nih.gov/36662895/
Dzinamarira T, Imran M, Muvunyi CM. The Management of Infectious Diseases in Comorbidity with Tuberculosis. Medicina (Kaunas). 2022 Oct 1;58(10). [accessed 24 Jun 2024] Available from: https://pubmed.ncbi.nlm.nih.gov/36295567/
Knight GM, McQuaid CF, Dodd PJ, Houben RMGJ. Global burden of latent multidrug-resistant tuberculosis: trends and estimates based on mathematical modelling. Lancet Infect Dis. 2019 Aug 1;19(8):903–12. doi: 10.1016/S1473-3099(19)30307-X
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