The Sensitivity, Specificity and Cutoff of Physical Activity and Psychological Stress on Chronic Kidney Disease
Abstract
Introduction: The prevalence of chronic kidney disease (CKD) in Kendari City, Southeast Sulawesi tends to increase. CKD is a Silent Killer disease, because sufferers do not realize it early. There are many risk factors for CKD, including low physical activity and psychological stress, but their effects on CKD unclears in Kendari City. The aim of study is to analyse level sensitivity, specificity and cutoff point of physical activity and psychological stress effect on CKD in Kendari City.
Methods: This study applied a quantitative method with cross sectional study recruited 136 people who aged 17-75 years old. They were interviewed with a questionnaire and took urine samples to determine proteinuria as a biomarker of CKD, using the 24-hour urinalysis method. Data analysis used the ROC curve at a 95% confidence interval (p<0.05) was considered statistically significant.
Results: This study found that physical activity had the ability to predict CKD by 68.6% (95%CI: 59.7%-77.5%). Meanwhile, the psychological stress variable has the ability to predict CKD is 76.1% (95% CI: 64.6%-87.7%). The sensitivity and specificity of physical activity are 62.9% and 63.6% respectively. The cut-off point of physical activity is 4.25 hours per day. Meanwhile, the sensitivity and specificity of psychological stress is 71.4% and 69.6% respectively. The Cutoff points for psychological stress is 12.50 or mild stress.
Conclusion: Physical activity and psychological stress variables can both be used to predict CKD in Kendari City. However, the ability of the psychological stress variable is slightly stronger than the physical activity variable. Someone who does physical activity equal to or above 4.25 hours per day is 62.9% less likely to suffer from kidney disease, compared to those whose physical activity is less than 4.25 hours per day. Thus, for someone who experiences mild psychological stress or above, they are 71.4% more likely to experience kidney disease, compared to those who are not stressed. The results of this study can contribute to the literature to determine program standards in carrying out health promotion and prevention towards controlling chronic kidney disease.
References
Health Ministry of Republic Indonesia. Basic Health Reseach (Riskesdas 2013). Jakarta: Ministry of Health of the Republic of Indonesia; 2013. p. 306.
Ministry of Health of the Republic of Indonesia. Indonesian Health Survey 2023. Jakarta: Ministry of Health of the Republic of Indonesia; 2023. p. 965.
Bahteramas Regional Hospital. Bahteramas Regional Hospital Report 2019. Kendari; 2020.
Bahteramas Regional Hospital. Bahteramas Regional Hospital Report 2018. Kendari; 2019.
Marreiros C, Viegas C, Simes D. Targeting a Silent Disease: Vascular Calcification in Chronic Kidney Disease. Mol Sci. 2022;23(16114):1–20.
Bellasi A, Lullo L Di, Iorio B Di. Chronic Kidney Disease: The Silent Epidemy. J Clin Med. 2019;8(1795):1–8.
Provenzano M, Coppolino G, Faga T, Garofalo C, Serra R, Andreucci M. Epidemiology of cardiovascular risk in chronic kidney disease patients: the real silent killer. Rev Cardiovasc Med. 2019;20(4):209–20.
Lewington AJP, Cerda J, Mehta RL. Raising awareness of acute kidney injury: a global perspective of a silent killer. Int Soc Nephrol. 2013;84:457–67.
Priyadarshani WVD, Namor AFD de, Silva SRP. Rising of a global silent killer: critical analysis of chronic kidney disease of uncertain aetiology (CKDu) worldwide and mitigation steps. Env Geochem Heal. 2023;45:2647–62.
Hustrini NM, Susalit E, Rotmans J. Prevalence and risk factors for chronic kidney disease in Indonesia: An analysis of the National Basic Health Survey 2018. J Glob Health. 2022;12(1):1–10.
Afera SL, Santoso SD, Santosa RI. Urine albumin to creatinine ratio as an early detection of impaired kidney function in diabetes mellitus. J SainHealth [Internet]. 2021;5(2):1–5. Available from: https://e-journal.umaha.ac.id/index.php/sainhealth/article/view/1516/pdf
Indrayani UD, Utami KD. Deteksi dini penyakit ginjal kronis pada pasien hipertensi dan diabetes melitus di Puskesmas Srondol. J Pengabdi Masy Kedokt. 2022;1(1):34–8.
Health Department of Southeast Sulawesi Province. Southeast Sulawesi Health Profile in 2021. Kendari: Health Department of Southeast Sulawesi Province; 2022. p. 296.
Mallamaci F, Pisan A, Tripepi G. Physical activity in chronic kidney disease and the EXerCise Introduction To Enhance trial. Nephrol Dial Transplan. 2020;35:18–22.
Barcellos F, Santos I, Umpierre D, et al. Effects of exercise in the whole spectrum of chronic kidney disease: a systematic review. Clin Kidney J. 2015;8:753–65.
Pei G, Tang Y, Tan L, Al. E. Aerobic exercise in adults with chronic kidney disease (CKD): a meta-analysis. Int Urolology Nephrol. 2019;51:1787–95.
McClellan WM, Abramson. J, Newsome B, Temple E, Wadley VG, Audhya P, et al. Physical and Psychological Burden of Chronic Kidney Disease among Older Adults. Am J Nephrol. 2010;31:309–17.
Tasnim T, Sugireng, Imran, Akib NI. Early Detection Patterns Of Chronic Kidney Disease Based On Differences In Individual Health Status In Kendari City. Indones J Heal Sci Res Dev. 2023;5(2):168–77.
Tasnim T, Sugireng., Imran., Akib NI. Analysis of differences in early detection of chronic kidney disease with urine creatinine, proteins and individual health status based on behavioural, stress and genetic factors in Kendari City, Indonesia. Public Heal Indones. 2024;10(2):203–13.
Kendari City Health Department. Health Profile 2022. Kendari: Kendari City Health Department; 2022. p. 211.
Yaribeygi H, Panahi Y, Sahraei H, Johnston TP, Sahebkar A. The impact of stess on body function: A review. EXCLI J. 2017;16:1057–72.
Hettiarachchi R, Abeysena C. Association of Poor Social Support and Financial Insecurity with Psychological Distress of Chronic Kidney Disease Patients Attending National Nephrology Unit in Sri Lanka. Int J Nephrol. 2018;5678781(1).
Tasnim. T, Sunarsih S. Penyakit Ginjal Kronis?: Indikator Dan Faktor Penentu. First. Kendari: Mandala Waluya Press; 2022. 110 p.
Tasnim., Imran., Sugireng., Akib NI, Akmal., Novita V, et al. Early Detection Models Untuk Pengendalian Penyakit Ginjal Kronik. Kendari: Mandala Waluya Press; 2023. 112 p.
Tasnim T, Sunarsih., Supodo T. The preventive model for chronic kidney disease in Coastal area Abeli Health Centre in Kendari City. Indones J Heal Sci Res Dev. 2023;5(2):63–72.
Estevez-Garcia JA, Tamayo-Ortiz M, Sanders AP. A Scoping Review of Life-Course Psychosocial Stress and Kidney Function. Children. 2021;8(810):1–13.
Etikan I, Bala K. Sampling and sampling methods. Biometrics Biostat Int J. 2017;5(6):149.
Etikan I, Musa SA, Alkassim RS. Comparison of convenience sampling and purposive sampling. Am J Theor Appl Stat. 2016;5(1):1–4.
Fassett RG, Venuthurupalli SK, Gobe GC, Coombes JS, Cooper MA, Hoy WE. Biomarkers in chronic kidney disease: a review. Kidney Int. 2011;80:806–21.
URIT Medical Electronic Co. L. URIT 13g Urine Reagent Strips. Guiling, China: URIT Medical Electronic Co.,Ltd.; 2021. p. Vers.04.
Sachs MC. plotROC: A Tool for Plotting ROC Curves. J Stat Softw. 2017;79:1–24.
Schisterman EF, Faraggi D, Reiser B, Hu J. Youden Index and the optimal threshold for markers with mass at zero. Stat Med. 2008;27(2):297–315.
Warburton DER, Bredin SSD. Reflections on physical activity and health: what should we recommend? Can J Cardiol. 2016;32(4):495–504.
Zhu Y, Bu Y, Zhang G, Ding S, Zhai D, Wan Z, et al. Association of physical activity with chronic kidney disease: a systematic review and dose-response meta-analysis. Aging (Albany NY). 2020;12(19):19221–32.
Yamamoto S, Inoue Y, Kuwahara K, Al. E. Leisure-time, occupational, and commuting physical activity and the risk of chronic kidney disease in a working population. Sci Reports. 2021;11(12308).
Ryota Matsuzawa, Roshanravan B, Shimoda T, Mamorita N, Yoneki K, Harada M, et al. Physical Activity Dose for Hemodialysis Patients: Where to Begin? Results from a Prospective Cohort Study. J Ren Nutr. 2018;28(1):45–53.
World Health Organization. WHO guidelines on physical activity and sedentary behaviour. Geneva: World Health Organization; 2020.
Hannan M, Ansari S, Meza N, Anderson AH, Srivastava A, Waikar S, et al. Risk Factors for CKD Progression: Overview of Findings from the CRIC Study. Clin J Am Soc Nephrol. 2021;16(4):648–59.
Tasnim T, Sunarsih. Analysis of impaired kidney function in the community around the Morosi nickel mines. J Public Health Africa. 2023;14(2700):1–6.
Tasnim T, Imran, Sugireng, Akib N. Early detection of the risk of chronic kidney disease based on eating and drinking behaviors in Kendari City Indonesia. Healthc Low-resource Settings. 2024;1–18.
Tasnim T, Rahmawati., Amraeni Y, Buton LD, Saparina L T, Mulyani S, et al. Analysis of High Levels of Urine Proteins as a Sign of Impaired Kidney Function in Communities Around a Nickel Mining Industry in Morosi District, Southeast Sulawesi. Epidemiol Biostat Public Heal. 2023;18(2):1–8.
Franklin BA, Eijsvogels TMH, Pandey A, Quindry J, Toth PP. Physical activity, cardiorespiratory fitness, and cardiovascular health: A clinical practice statement of the American Society for Preventive Cardiology Part II: Physical activity, cardiorespiratory fitness, minimum and goal intensities for exercise train. Am J Prev Cardiol. 2022;12(100425):1–16.
Hayes P, Ferrara A, Keating A, McKnight K, O’Regan A. Physical Activity and Hypertension. Rev Cardiovasc Med. 2022;23(9):302.
Choi NG, Sullivan JE, DiNitto DM, Kunik ME. Associations between psychological distress and health-related behaviors among adults with chronic kidney disease. Prev Med (Baltim). 2019;126(105749).
Wang F, He K, Wang J, Zhao MH, Li Y, Zhang L, et al. Prevalence and Risk Factors for CKD: A Comparison Between the Adult Populations in China and the United States. Kidney Int Reports. 2018;3:1135–1143.
Lupien S, McEwen B, Gunnar M, Heim C. Effects of stress throughout the lifespan on the brain, behaviour and cognition. Nat Rev Neurosci. 2009;10:434–45.
Sarahian N, Sahraei H, Zardooz H, Alibeik H, Sadeghi B. Effect of memantine administration within the nucleus accumbens on changes in weight and volume of the brain and adrenal gland during chronic stress in female mice. Modares J Med Sci Pathobiol. 2014;17:71–82.
Reiche E, Nunes S, Morimoto H. Stress, depression, the immune system, and cancer. Lancet Oncol. 2004;5:617–25.
Carrasco G, Van de Kar L. Neuroendocrine pharmacology of stress. Eur J Pharmacol. 2003;463:235–7.
Vrijkotte T, Van Doornen L, De Geus E. Effects of work stress on ambulatory blood pressure, heart rate, and heart rate variability. Hypertension. 2000;35:880–6.
Copyright (c) 2025 Journal of Public Health and Pharmacy

This work is licensed under a Creative Commons Attribution-ShareAlike 4.0 International License.
Authors who publish with Journal of Public Health and Pharmacy retain the copyright of their work. The journal applies a Creative Commons Attribution-ShareAlike 4.0 International License (CC BY-SA 4.0), which grants the following rights:
-
Copyright Retention: Authors retain the copyright of their work, maintaining full control over their intellectual property without restrictions.
-
Right of First Publication: Authors grant the journal the right of first publication of their work. This ensures that the work is initially published and credited in Journal of Public Health and Pharmacy.
-
License to Share and Reuse: The work is licensed under CC BY-SA 4.0, allowing others to copy, distribute, remix, and build upon the work for any purpose, even commercially, as long as proper credit is given to the authors, and any new creations are licensed under the same terms.