Antiseptic and Disinfectant Utilization Patterns at Tlemcen University Hospital Center: A Five-Year Epidemiological Study

  • Amel Berrached Laboratory of Microbiology applied to the Food industry, Biomedical and the Environment, Faculty of Natural and Life Sciences, Earth and Universe Sciences. Department of Biology. University of Tlemcen, Tlemcen,13000, Algeria.
  • Hafida Hassaine Laboratory of Microbiology applied to the Food industry, Biomedical and the Environment, Faculty of Natural and Life Sciences, Earth and Universe Sciences. Department of Biology. University of Tlemcen, Tlemcen,13000, Algeria.
  • Fethi Borsali Laboratory of Dynamic Systems and Applications, University of Tlemcen, Tlemcen, Algeria
  • Nezha Bereksi Reguig Berber Senior General Pharmacist, University Hospital Center of Tlemcen, Algeria
  • Amel Chiali Laboratory of Microbiology applied to the Food industry, Biomedical and the Environment, Faculty of Natural and Life Sciences, Earth and Universe Sciences. Department of Biology. University of Tlemcen, Tlemcen,13000, Algeria.
  • Lamia Boublenza Laboratory of Microbiology applied to the Food industry, Biomedical and the Environment, Faculty of Natural and Life Sciences, Earth and Universe Sciences. Department of Biology. University of Tlemcen, Tlemcen,13000, Algeria.
  • Ilyes Zatla Laboratory of Microbiology applied to the Food industry, Biomedical and the Environment, Faculty of Natural and Life Sciences, Earth and Universe Sciences. Department of Biology. University of Tlemcen, Tlemcen,13000, Algeria.
DOI: https://doi.org/10.56338/jphp.v5i2.5442
Keywords: Antiseptic, Disinfectant, Surfaces, Medical instruments, Hospital

Abstract

Introduction: Disinfectants and antiseptics are integral components of hospital infection control policies; however, their overuse can lead to microbial resistance, a growing concern in healthcare settings. This study aims to analyze the consumption patterns of antiseptics and disinfectants across various departments of Tlemcen University Hospital Center (CHU), providing insights into their usage over a five-year period and helping inform strategies for more responsible use.

Methods: Data on the consumption of Povidone iodine (PVI) and various disinfectants across 20 departments over a five-year period (2015–2019) were obtained from the pharmacy and relevant CHU departments. Statistical analysis was conducted using SPSS version 25. Chi-square tests were employed to compare categorical data, and ANOVA was used to assess trends in consumption over time.

Results: The results revealed a decline in PVI consumption to 13.5% in 2019, while disinfectant use increased by 29.1%, possibly due to a reduction in surgical procedures and an increase in medical admissions. Notably, consumption patterns varied across departments, with surgical services showing higher disinfectant use compared to medical services.

Conclusion: Given the extensive use of antiseptics and disinfectants, we recommend implementing strategies to reduce their overuse, such as periodic audits of antimicrobial consumption and educational programs for healthcare professionals to mitigate the risk of microbial resistance.

 

References

Zhao X, Wang C. Rational application of antiseptic drugs in arthroplasty and nursing intervention. Pak J Pharm Sci. 2018.

González LL, Pérez MIG, Menéndez MEL-V, Lluch NA, Agustí MLM, Cachafeiro SP, et al. Introducción a losantisépticos. Atencionprimaria. 2014;46:1-9.

He XF, Zhang HJ, Cao JG, Liu F, Wang JK, Ma WJ, et al. A novel method to detect bacterial resistance to disinfectants. Genes Dis. 2017;4(3):163-9.

Chen S, Chen JW, Guo B, Xu CC. Preoperative Antisepsis with Chlorhexidine Versus Povidone-Iodine for the Prevention of Surgical Site Infection: a Systematic Review and Meta-analysis. World J Surg. 2020;44(5):1412-24.

Protano C, Cammalleri V, Romano Spica V, Valeriani F, Vitali M. Hospital environment as a reservoir for cross transmission: cleaning and disinfection procedures. Ann Ig. 2019;31(5):436-48.

AminiTapouk F, Nabizadeh R, Mirzaei N, Hosseini Jazani N, Yousefi M, ValizadeHasanloei MA. Comparative efficacy of hospital disinfectants against nosocomial infection pathogens. Antimicrob Resist Infect Control. 2020;9(1):115.

Shan K, Li J, Yao W, Li J, He X, Li F, et al. Evaluation of Resistance by Clinically Pathogenic Bacteria to Antimicrobials and Common Disinfectants in Beijing, China. J Nippon Med Sch. 2018;85(6):302-8.

Singh M, Sharma R, Gupta PK, Rana JK, Sharma M, Taneja N. Comparative efficacy evaluation of disinfectants routinely used in hospital practice: India. Indian J Crit Care Med. 2012;16(3):123-9.

Hasheminia D, Moaddabi A, Moradi S, Soltani P, Moannaei M, Issazadeh M. The efficacy of 1% Betadine mouthwash on the incidence of dry socket after mandibular third molar surgery. J Clin Exp Dent. 2018;10(5):E445-E9.

PARK E-S, JEONG J-S, KIM K-M, KIM O-S, JEONG S-Y, JANG S-Y, et al. Descriptive study on the current usage of disinfectants in Korea. Korean J Nosocomial Infect Control. 2006:42-9.

Eggers M, Koburger-Janssen T, Ward LS, Newby C, Muller S. Bactericidal and Virucidal Activity of Povidone-Iodine and Chlorhexidine Gluconate Cleansers in an In Vivo Hand Hygiene Clinical Simulation Study. Infect Dis Ther. 2018;7(2):235-47.

Chaiyakunapruk N, Veenstra DL, Lipsky BA, Sullivan SD, Saint S. Vascular catheter site care: the clinical and economic benefits of chlorhexidine gluconate compared with povidone iodine. Clin Infect Dis. 2003;37(6):764-71.

Patrick S, McDowell A, Lee A, Frau A, Martin U, Gardner E, et al. Antisepsis of the skin before spinal surgery with povidone iodine-alcohol followed by chlorhexidine gluconate-alcohol versus povidone iodine-alcohol applied twice for the prevention of contamination of the wound by bacteria: a randomised controlled trial. Bone Joint J. 2017;99(10):1354-65.

Yoshii T, Hirai T, Yamada T, Sakai K, Ushio S, Egawa S, et al. A prospective comparative study in skin antiseptic solutions for posterior spine Surgeries: Chlorhexidine-Gluconate ethanol versus Povidone-Iodine. Clin Spine Surg. 2018;31(7):E353-E6.

Penna TCV, Mazzola PG, Silva Martins AM. The efficacy of chemical agents in cleaning and disinfection programs. BMC Infect Dis. 2001;1(1):1-8.

Matsubara H, Togashi A, Takahashi M, Sagawa K, Shimada S. Survey on the actual status of use of antiseptics in our hospital. Dermatol. 2002;204(Suppl. 1):6-14.

Weber DJ, Rutala WA, Sickbert-Bennett EE. Use of germicides in health care settings-is there a relationship between germicide use and antimicrobial resistance: A concise review. Am J Infect Control. 2019;47S:A106-A9.

Shiraishi T, Nakagawa Y, Matsubara H, Takada Y, Arai Y, Okada S, et al. A survey of the appropriate use of antiseptic agents in the operating room of several key health care facilities. A comparison between surveys in 2000 and 2004. Dermatol. 2006;212 Suppl 1:15-20.

Seifi B, Sahbaei F, Zare MZ, Abdoli A, Heidari M. A Comparative Study between Povidone-Iodine and Manugel 85 on Surgical Scrub. Mater Sociomed. 2016;28(5):348-52.

Pedrotti E, Bonacci E, Kilian R, Pagnacco C, Fasolo A, Anastasi M, et al. The Role of Topical Povidone-Iodine in the Management of Infectious Keratitis: A Pilot Study. J Clin Med. 2022;11(3).

Akrim J, Ousaid A, Lazim M, Khayati Y. Les bonnes pratiques d’utilisation des antiseptiques: enquête à l’hôpital Cheikh Khalifa de Casablanca. Pharma Hosp Clin. 2018;53(2):147-55.

Merrer J, Lefrant JY, Timsit JF. How to improve central venous catheter use in intensive care unit?. Ann Fr Anesth Reanim. 2006;25(2):180-8.

Manolis AS, Melita H. Prevention of Cardiac Implantable Electronic Device Infections: Single Operator Technique with Use of Povidone-Iodine, Double Gloving, Meticulous Aseptic/Antiseptic Measures and Antibiotic Prophylaxis. Pacing Clin Electrophysiol. 2017;40(1):26-34.

Lee M, Van Bever H. The role of antiseptic agents in atopic dermatitis. Asia Pac Allergy. 2014;4(4):230-40.

Cowley NL, Forbes S, Amezquita A, McClure P, Humphreys GJ, McBain AJ. Effects of Formulation on Microbicide Potency and Mitigation of the Development of Bacterial Insusceptibility. Appl Environ Microbiol. 2015;81(20):7330-8.

HenounLoukili N, Becker H, Harno J, Bientz M, Meunier O. Effect of peracetic acid and aldehyde disinfectants on biofilm. J Hosp Infect. 2004;58(2):151-4.

Jaouhar S, Lalami AEO, Bouzid J, Zeouk I, Bekhti K, editors. Susceptibility patterns of bacteria isolated from the hospital environment towards disinfectants commonly used for surfaces and medical devices. E3S Web of Conf. 2021;319:01081

Murtough SM, Hiom SJ, Palmer M, Russell AD. A survey of rotational use of biocides in hospital pharmacy aseptic units. J Hosp Infect. 2002;50(3):228-31.

Biswas D, Tiwari M, Tiwari V. Comparative mechanism based study on disinfectants against multidrug-resistant Acinetobacter baumannii. J Cell Biochem. 2018;119(12):10314-26.

Berthelot P. Désinfection du matériel et des appareils utilisés par le réanimateur. Réanimation. 2005;14(4):294-301.

White AM, Mutai D, Cheruiyot D, Rule ARL, Mortensen JE, Schaffzin JK, et al. Disinfection of Neonatal Resuscitation Equipment in Low-Resource Settings: The Importance, the Reality, and Considerations for the Future. Int J Environ Res Pub Heal. 2021;18(13).

Talon D. The role of the hospital environment in the epidemiology of multi-resistant bacteria. J Hosp Infect. 1999;43(1):13-7.

Christen V, Faltermann S, Brun NR, Kunz PY, Fent K. Cytotoxicity and molecular effects of biocidal disinfectants (quaternary ammonia, glutaraldehyde, poly(hexamethylene biguanide) hydrochloride PHMB) and their mixtures in vitro and in zebrafish eleuthero-embryos. Sci Total Environ. 2017;586:1204-18

Tennstedt D. Pathologies induites par les ammoniums quaternaires: de la maison au travail: Pathologies dermatologiques. Rev Fr Allergol Immunol Clin. 2008;48(3):246-8.

White LF, Dancer SJ, Robertson C. A microbiological evaluation of hospital cleaning methods. Int J Environ Health Res. 2007;17(4):285-95.

Kose H, Yapar N. The comparison of various disinfectants? efficacy on Staphylococcus aureus and Pseudomonas aeruginosa biofilm layers. Turk J Med Sci. 2017;47(4):1287-94.

Brosio F, Kuhdari P, Stefanati A, Sulcaj N, Lupi S, Guidi E, et al. Knowledge and behaviour of nursing students on the prevention of healthcare associated infections. J Prev Med Hyg. 2017;58(2):E99.

Lopez-Gigosos RM, Mariscal-Lopez E, Gutierrez-Bedmar M, Garcia-Rodriguez A, Mariscal A. Evaluation of antimicrobial persistent activity of alcohol-based hand antiseptics against bacterial contamination. Eur J Clin Microbiol Infect Dis. 2017;36(7):1197-203.

Zakeri H, Ahmadi F, Rafeemanesh E, Saleh LA. The knowledge of hand hygiene among the healthcare workers of two teaching hospitals in Mashhad. Electron physician. 2017;9(8):5159.

Ahmed J, Malik F, Memon ZA, Bin Arif T, Ali A, Nasim S, et al. Compliance and Knowledge of Healthcare Workers Regarding Hand Hygiene and Use of Disinfectants: A Study Based in Karachi. Cureus. 2020;12(2):e7036.

Pittet D, Hugonnet S, Harbarth S, Mourouga P, Sauvan V, Touveneau S, et al. Effectiveness of a hospital-wide programme to improve compliance with hand hygiene. Lancet. 2000;356(9238):1307-12.

Szabo R, Morvai J, Bellissimo-Rodrigues F, Pittet D. Use of hand hygiene agents as a surrogate marker of compliance in Hungarian long-term care facilities: first nationwide survey. Antimicrob Resist Infect Control. 2015;4:32.

Quinn MM, Henneberger PK, National Institute for Occupational S, Health NORAC, Disinfecting in Healthcare Working G, Braun B, et al. Cleaning and disinfecting environmental surfaces in health care: Toward an integrated framework for infection and occupational illness prevention. Am J Infect Control. 2015;43(5):424-34.

Published
2025-07-01
How to Cite
Amel Berrached, Hafida Hassaine, Fethi Borsali, Nezha Bereksi Reguig Berber, Amel Chiali, Lamia Boublenza, & Zatla, I. (2025). Antiseptic and Disinfectant Utilization Patterns at Tlemcen University Hospital Center: A Five-Year Epidemiological Study. Journal of Public Health and Pharmacy, 5(2), 308-319. https://doi.org/10.56338/jphp.v5i2.5442
Issue
Vol. 5 No. 2: JULY 2025
Section
Articles

Copyright (c) 2025 Journal of Public Health and Pharmacy

Creative Commons License

This work is licensed under a Creative Commons Attribution-ShareAlike 4.0 International License.

Authors who publish with Journal of Public Health and Pharmacy retain the copyright of their work. The journal applies a Creative Commons Attribution-ShareAlike 4.0 International License (CC BY-SA 4.0), which grants the following rights:

  1. Copyright Retention: Authors retain the copyright of their work, maintaining full control over their intellectual property without restrictions.

  2. Right of First Publication: Authors grant the journal the right of first publication of their work. This ensures that the work is initially published and credited in Journal of Public Health and Pharmacy.

  3. License to Share and Reuse: The work is licensed under CC BY-SA 4.0, allowing others to copy, distribute, remix, and build upon the work for any purpose, even commercially, as long as proper credit is given to the authors, and any new creations are licensed under the same terms.