Factors Affecting Treatment Adherence Among Patients with Tuberculosis in Indonesia: Literature Review

  • Fahrul Islam Environmental Health Departement, Poltekkes Kemenkes Mamuju, Sulawesi Barat, Indonesia
  • Haeranah Ahmad Environmental Health Departement, Poltekkes Kemenkes Mamuju, Sulawesi Barat, Indonesia
  • Nurbaya Nutrition Departement, Poltekkes Kemenkes Mamuju, Sulawesi Barat, Indonesia
  • Masnaeni Ahmad Nursing Departement, Poltekkes Kemenkes Mamuju, Sulawesi Barat, Indonesia
  • Ansar Nutrition Departement, Poltekkes Kemenkes Palu, Sulawesi Tengah, Indonesia
  • Kadar Ramadhan Midwifery Departement, Poltekkes Kemenkes Palu, Sulawesi Tengah, Indonesia
  • Muhammad Syukri Faculty of Public Health, Universitas Jambi, Jambi, Indonesia
  • Syafran Arrazy Faculty of Public Health, UIN Sumatera Utara, Sumatera Utara, Indonesia
  • Agung Aji Perdana Faculty of Public Health, Universitas Malahayati, Lampung, Indonesia
  • Deborah Siregar Faculty of Nursing, Universitas Pelita Harapan, Jakarta, Indonesia
  • Nining Ade Ningsih Faculty of Public Health, STIK Tamalatea Makassar, Sulawesi Selatan, Indonesia
  • Ikes Dwi Astuti Badan Narkotika Nasional Palopo, Sulawesi Selatan, Indonesia
  • St. Kadijah Hamid Puskesmas Tampapadang Mamuju, Sulawesi Barat, Indonesia
  • Asrul Hamonangan Pasaribu Dinas Kesehatan Kabupaten Padang Lawas, Sumatera Utara, Indonesia
Keywords: Adherence, Treatment, Tuberculosis

Abstract

Introduction: Tuberculosis (TB) is the leading cause of death from infectious diseases in the world and Indonesia is the second largest contributor to TB cases after India. Treatment adherence problems are a major obstacle to TB elimination. The purpose of this Literature Review is to determine the factors that affect treatment adherence among TB patients in Indonesia.

Methods: Literature obtained from Science Direct, PubMed, and Google Scholar; published from 2018 – 2023, research from reputable international journals and from national journals at least with SINTA 3, located in Indonesia. Indonesian and English with full text of all types of research designs. Article selection was carried out using the method "Preferred Reporting Items for Systematic Review and Meta-Analysis (PRISMA) and analyzed using descriptive analysis techniques.

Results: A total of 225 articels were deemed appropriate for the topic, but only 15 articles were included based on inclusion criteria. It was found that there are several factors that affect treatment adherence in tuberculosis patients in Indonesia, namely: predisposing factors as many as 11 articles (age, education, occupation, knowledge, self-efficacy, concordance, health behavior, motivation, marital status, income level, drug side effects, already feeling cured, and duration of treatment). Reinforcing factors as many as 2 articles (family support). Enabling factors as many as 5 articles (the role of officers, reminder SMS messages from officers, health counseling, and distance of residence to health services).

Conclusion: The most dominant factor affecting treatment adherence among tuberculosis patients in Indonesia is the Predesposising factors, namely education and sefl-efficacy.

References

Centers for Disease Control and Prevention. Tuberculosis [Internet]. 2020 [cited 2023 May 21]. Available from: https://www.cdc.gov/globalhealth/newsroom/topics/tb/index.html

Pradhan A, Koirala P, Bhandari SS, Dutta S, García-Grau P, Sampath H, et al. Internalized and Perceived Stigma and Depression in Pulmonary Tuberculosis: Do They Explain the Relationship Between Drug Sensitivity Status and Adherence? Front Psychiatry [Internet]. 2022 May 19;13(May):1–8. Available from: https://www.frontiersin.org/articles/10.3389/fpsyt.2022.869647/full

Nezenega ZS, Perimal-Lewis L, Maeder AJ. Factors Influencing Patient Adherence to Tuberculosis Treatment in Ethiopia: A Literature Review. Int J Environ Res Public Health [Internet]. 2020 Aug 4;17(15):5626. Available from: https://www.mdpi.com/1660-4601/17/15/5626

Biro Komunikasi dan Pelayanan Publik Kementerian Kesehatan RI. Deteksi TBC Capai Rekor Tertinggi di Tahun 2022 [Internet]. 2023. Available from: https://sehatnegeriku.kemkes.go.id/baca/rilis-media/20230331/3942688/deteksi-tbc-capai-rekor-tertinggi-di-tahun-2022/

Kementrian Kesehatan RI. Kebijakan Manajemen Infeksi Laten Tuberkulosis (ILTB) dan Pemberian Terapi Pencegahan Tuberkulosis (TPT) di Indonesia. www.https://tbindonesia.or.id/; 2023.

World Helath Organizatiaon. Global Tuberculosis Report [Internet]. WHO; 2022. Available from: https://www.who.int/teams/global-tuberculosis-programme/tb-reports/global-tuberculosis-report-2022

Zegeye A, Dessie G, Wagnew F, Gebrie A, Islam SMS, Tesfaye B, et al. Prevalence and determinants of anti-tuberculosis treatment non-adherence in Ethiopia: A systematic review and meta-analysis. Mandalakas AM, editor. PLoS One [Internet]. 2019 Jan 10;14(1):e0210422. Available from: https://dx.plos.org/10.1371/journal.pone.0210422

Liu X, Thompson J, Dong H, Sweeney S, Li X, Yuan Y, et al. Digital adherence technologies to improve tuberculosis treatment outcomes in China: a cluster-randomised superiority trial. Lancet Glob Heal [Internet]. 2023 May;11(5):e693–703. Available from: http://dx.doi.org/10.1016/S2214-109X(23)00068-2

Maretasari FD. Direktorat Jenderal Pelayanan Kesehatan Kementerian Kesehatan RI. 2022. Kepatuhan Pengobatan Pada TBC.

Gbeasor-Komlanvi FA, Sadio AJ, Adama OI, Zida-Compaore WIC, Tchankoni MK, Adjoh KS, et al. Medicinal plant use and adherence problems to TB treatment. Int J Tuberc Lung Dis [Internet]. 2022 Sep 1;26(9):850–6. Available from: https://www.ingentaconnect.com/content/10.5588/ijtld.21.0555

Saha S, Saxena D, Raval D, Halkarni N, Doshi R, Joshi M, et al. Tuberculosis Monitoring Encouragement Adherence Drive (TMEAD): Toward improving the adherence of the patients with drug-sensitive tuberculosis in Nashik, Maharashtra. Front Public Heal [Internet]. 2022 Dec 21;10. Available from: https://www.frontiersin.org/articles/10.3389/fpubh.2022.1021427/full

Ridho A, Alfian SD, van Boven JFM, Levita J, Yalcin EA, Le L, et al. Digital Health Technologies to Improve Medication Adherence and Treatment Outcomes in Patients With Tuberculosis: Systematic Review of Randomized Controlled Trials. J Med Internet Res [Internet]. 2022 Feb 23;24(2):e33062. Available from: https://www.jmir.org/2022/2/e33062

C H, Mc R, Jamal S. Factors Affecting Treatment Compliance among Tuberculosis Patients at Dots Centre after Introduction of Daily Regimen and Fixed Dose Combination. J Assoc Physicians India [Internet]. 2022 Apr;70(4):11–2. Available from: https://pubmed.ncbi.nlm.nih.gov/35443461/

Karat AS, Jones ASK, Abubakar I, Campbell CNJ, Clarke AL, Clarke CS, et al. “You have to change your whole life”: A qualitative study of the dynamics of treatment adherence among adults with tuberculosis in the United Kingdom. J Clin Tuberc Other Mycobact Dis [Internet]. 2021 May;23:100233. Available from: https://doi.org/10.1016/j.jctube.2021.100233

Ulfah U, Windiyaningsih C, Abidin Z, Murtiani F. Faktor-Faktor yang Berhubungan dengan Kepatuhan Berobat Pada Penderita Tuberkulosis Paru. Indones J Infect Dis [Internet]. 2018 Dec 28;4(1). Available from: http://mail.ijid-rspisuliantisaroso.co.id/index.php/ijid/article/view/44

Usmanova R, Parpieva N, Davtyan H, Denisiuk O, Gadoev J, Alaverdyan S, et al. Treatment Compliance of Multidrug Resistant Tuberculosis in Uzbekistan: Does Practice Follow Policy? Int J Environ Res Public Health [Internet]. 2021 Apr 12;18(8):4071. Available from: https://www.mdpi.com/1660-4601/18/8/4071

Gashu KD, Gelaye KA, Mekonnen ZA, Lester R, Tilahun B. Does phone messaging improves tuberculosis treatment success? A systematic review and meta-analysis. BMC Infect Dis [Internet]. 2020 Dec 14;20(1):42. Available from: https://bmcinfectdis.biomedcentral.com/articles/10.1186/s12879-020-4765-x

Amalia KP, Rahayu S, Harfiani E. Factors Associated with Successful Tuberculosis Treatment in the Primary Health Care of Bekasi. Epidemiol Soc Heal Rev [Internet]. 2022 Aug 6;4(2):69–75. Available from: http://journal2.uad.ac.id/index.php/eshr/article/view/5097

Vernon A, Fielding K, Savic R, Dodd L, Nahid P. The importance of adherence in tuberculosis treatment clinical trials and its relevance in explanatory and pragmatic trials. PLOS Med [Internet]. 2019 Dec 10;16(12):e1002884. Available from: https://dx.plos.org/10.1371/journal.pmed.1002884

Adisa R, Ayandokun TT, Ige OM. Knowledge about tuberculosis, treatment adherence and outcome among ambulatory patients with drug-sensitive tuberculosis in two directly-observed treatment centres in Southwest Nigeria. BMC Public Health [Internet]. 2021 Dec 7;21(1):677. Available from: https://bmcpublichealth.biomedcentral.com/articles/10.1186/s12889-021-10698-9

Pradipta IS, Houtsma D, van Boven JFM, Alffenaar JWC, Hak E. Interventions to improve medication adherence in tuberculosis patients: a systematic review of randomized controlled studies. npj Prim Care Respir Med [Internet]. 2020 May 11;30(1):21. Available from: http://dx.doi.org/10.1038/s41533-020-0179-x

Efendi S, Sjattar EL, Syam Y. Health counseling support medication adherence to regular pulmonary tuberculosis patients. Clin Epidemiol Glob Heal [Internet]. 2022 May;15(December 2021):101055. Available from: https://doi.org/10.1016/j.cegh.2022.101055

Chen SH, Wang I, Hsu HL, Huang CC, Liu YJ, Putri DU, et al. Advantage in privacy protection by using synchronous video observed treatment enhances treatment adherence among patients with latent tuberculosis infection. J Infect Public Health [Internet]. 2020 Sep;13(9):1354–9. Available from: https://doi.org/10.1016/j.jiph.2020.03.013

Alipanah N, Jarlsberg L, Miller C, Linh NN, Falzon D, Jaramillo E, et al. Adherence interventions and outcomes of tuberculosis treatment: A systematic review and meta-analysis of trials and observational studies. Murray M, editor. PLOS Med [Internet]. 2018 Jul 3;15(7):e1002595. Available from: https://dx.plos.org/10.1371/journal.pmed.1002595

Okethwangu D, Birungi D, Biribawa C, Kwesiga B, Turyahabwe S, Ario AR, et al. Multidrug-resistant tuberculosis outbreak associated with poor treatment adherence and delayed treatment: Arua District, Uganda, 2013–2017. BMC Infect Dis [Internet]. 2019 Dec 7;19(1):387. Available from: https://bmcinfectdis.biomedcentral.com/articles/10.1186/s12879-019-4014-3

Soedarsono S, Mertaniasih NM, Kusmiati T, Permatasari A, Juliasih NN, Hadi C, et al. Determinant factors for loss to follow-up in drug-resistant tuberculosis patients: the importance of psycho-social and economic aspects. BMC Pulm Med [Internet]. 2021 Dec 10;21(1):360. Available from: https://doi.org/10.1186/s12890-021-01735-9

Tibble H, Flook M, Sheikh A, Tsanas A, Horne R, Vrijens B, et al. Measuring and reporting treatment adherence: What can we learn by comparing two respiratory conditions? Br J Clin Pharmacol [Internet]. 2021 Mar 27;87(3):825–36. Available from: https://onlinelibrary.wiley.com/doi/10.1111/bcp.14458

Khamis KM, Kadir Shahar H, Abdul Manaf R, Hamdan HM. Effectiveness of education intervention of tuberculosis treatment adherence in Khartoum State: A study protocol for a randomized control trial. Abdelbasset WK, editor. PLoS One [Internet]. 2022 Nov 28;17(11):e0277888. Available from: http://dx.doi.org/10.1371/journal.pone.0277888

Condeng B. Effects of Counseling on the Quality of Life of MDR Lung TB Patients. Poltekita J Ilmu Kesehat [Internet]. 2023 May 29;17(1):67–75. Available from: https://jurnal.poltekkespalu.ac.id/index.php/JIK/article/view/2177

Asriwati, Yeti E, Niakurniawati, Usman AN. Risk factors analysis of non-compliance of Tuberculosis (TB) patients taking medicine in Puskesmas Polonia, Medan, 2021. Gac Sanit [Internet]. 2021;35(S2):S227–30. Available from: https://doi.org/10.1016/j.gaceta.2021.10.027

Karuniawati H, Putra ON, Wikantyasning ER. Impact of pharmacist counseling and leaflet on the adherence of pulmonary tuberculosis patients in lungs hospital in Indonesia. Indian J Tuberc [Internet]. 2019 Jul;66(3):364–9. Available from: https://doi.org/10.1016/j.ijtb.2019.02.015

Ernawati, Saleh A, Pasinringi SA, Abrar EA. The influence of expert patients on the increase of medication adherence among tuberculosis patients. Enfermería Clínica [Internet]. 2020 Mar;30(S2):276–8. Available from: https://doi.org/10.1016/j.enfcli.2019.07.103

Zainal S. M, Sapar, Syafruddin, Irwandy. The effect of patients’ perception about tuberculosis (TB) against treatment compliance. Enfermería Clínica [Internet]. 2020 Mar;30(S2):416–9. Available from: https://doi.org/10.1016/j.enfcli.2019.07.128

Dewi SR, Shalsabila LY, Fitriah N, Rahmah W. Hubungan Efikasi Diri dengan Kepatuhan Minum Obat Pasien Tb Paru di Rumah Sakit Dirgahayu Samarinda. Med Sains J Ilm Kefarmasian [Internet]. 2022 Mar 23;7(1):21–8. Available from: https://ojs.stfmuhammadiyahcirebon.ac.id/index.php/iojs/article/view/299

Sutarto S, Fauzi YS, Indriyani R, Sumekar RW DW, Wibowo A. Efikasi Diri pada Kepatuhan Minum Obat Anti Tuberkulosis (OAT). J Kesehat [Internet]. 2019 Nov 30;10(3):405. Available from: http://ejurnal.poltekkes-tjk.ac.id/index.php/JK/article/view/1479

Absor S, Nurida A, Levani Y, Nerly WS. Hubungan Tingkat Pendidikan Dengan Kepatuhan Berobat Penderita Tb Paru Di Wilayah Kabupaten Lamongan Pada Januari 2016 – Desember 2018. Medica Arter [Internet]. 2020 Dec 31;2(2):80. Available from: https://jurnal.unimus.ac.id/index.php/MedArt/article/view/6143

Siregar I, Siagian P, Effendy E. Dukungan Keluarga meningkatkan Kepatuhan Minum Obat pada Penderita Tuberkulosis Paru di Kabupaten Tapanuli Utara. J Kedokt Brawijaya [Internet]. 2019 Aug 30;30(4):309–12. Available from: https://jkb.ub.ac.id/index.php/jkb/article/view/2496

Lucya V, Arief NT. Factor Affecting Treatment Compliance in TB Patients. J Keperawatan Komprehensif (Comprehensive Nurs Journal) [Internet]. 2022 Oct 31;8(4):433–576. Available from: https://journal.stikep-ppnijabar.ac.id/index.php/jkk/article/view/442

Nasrullah D, Hasanah U, Choliq I, Purnamasari I, Firman F, Syaifurrahman I, et al. Factors Affecting Tuberculosis (Tb) Patient Adherence To Anti-Tuberculosis Drug Therapy In Surabaya. Gaster [Internet]. 2023 Feb 1;21(1):20–32. Available from: https://journal.aiska-university.ac.id/index.php/gaster/article/view/1020

Sukartini T, Widianingrum TR, Yasmara D. The relationship of knowledge and motivation with anti tuberculosis drugs compliance in tuberculosis patients. Syst Rev Pharm [Internet]. 2020;11(5):603–6. Available from: https://www.sysrevpharm.org/abstract/the-relationship-of-knowledge-and-motivation-with-anti-tuberculosis-drugs-compliance-in-tuberculosis-patients-66236.html

Perwitasari DA, Setiawan D, Nguyen T, Pratiwi A, Rahma Fauziah L, Saebrinah E, et al. Investigating the Relationship between Knowledge and Hepatotoxic Effects with Medication Adherence of TB Patients in Banyumas Regency, Indonesia. Sattar A, editor. Int J Clin Pract [Internet]. 2022 Aug 30;2022:1–6. Available from: https://www.hindawi.com/journals/ijclp/2022/4044530/

Dewi FST, Sudiya S, Supriyati S, Purwanta P, Madyaningrum E, Aulia FU, et al. Preparing Short Message Service Reminders to Improve Treatment Adherence among Tuberculosis Patients in Sleman District, Indonesia. Indian J Community Med [Internet]. 2019;44(2):81–7. Available from: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6625254/

Pandia P, Syafiuddin T, Bachtiar A, Rochadi K. The Relationship between Concordance Behaviour with Treatment Compliance and Quality Of Life of Patients with Pulmonary Tuberculosis in Medan. Open Access Maced J Med Sci [Internet]. 2019 May 15;7(9):1536–9. Available from: https://spiroski.migration.publicknowledgeproject.org/index.php/mjms/article/view/oamjms.2019.321

Yani DI, Juniarti N, Lukman M. Factors Related to Complying with Anti-TB Medications Among Drug-Resistant Tuberculosis Patients in Indonesia. Patient Prefer Adherence [Internet]. 2022 Dec;16(December):3319–27. Available from: https://www.dovepress.com/factors-related-to-complying-with-anti-tb-medications-among-drug-resis-peer-reviewed-fulltext-article-PPA

Published
2024-03-11
How to Cite
Islam, F., Ahmad, H., Nurbaya, Ahmad , M., Ansar, Ramadhan, K., Syukri, M., Arrazy, S., Aji Perdana, A., Siregar, D., Ade Ningsih, N., Dwi Astuti, I., Kadijah Hamid, S., & Hamonangan Pasaribu, A. (2024). Factors Affecting Treatment Adherence Among Patients with Tuberculosis in Indonesia: Literature Review. Journal of Public Health and Pharmacy, 4(1), 28-37. https://doi.org/10.56338/jphp.v4i1.5022
Section
Articles