Depression among Tuberculosis Patients and its Association with Medication Adherence of Anti-Tuberculosis Drugs Literature Review
Abstract
Introduction: Tuberculosis or known as TBC is one of communicable disease that caused by the bacillus Mycobacterium tuberculosis. This disease is the major of public health problem due to it can spread easily from the patients to the healthy people by air transmission. In order to stop the transmission and improve the health status of the community, treatment is needed for patients with tuberculosis. But, almost people with tuberculosis patients had poor treatment and the factor that contribute to their adherence is depression. Depression and tuberculosis are frequently coexisting in individuals. Depression lead them having negative perception about the treatment and get misconceptions about TB disease. Therefore, most of tuberculosis patients with depression are having lower level of medication adherence.
Objective: The purpose of this literature review is to analyze the association between depression among tuberculosis patients with medication adherence of anti-tuberculosis.
Method:.This study uses the literature review method to review the results of research that has been published by previous researchers. The literature sources obtained were the results of searches from three online databases, namely Google scholars, Pubmed, and Scopus. which published in the range of 2018-2024.
Result: Depression was significantly associated with medication adherence among people who had tuberculosis
Conclusion: Depression appears to be a strong risk factor for treatment failure and default in these people with newly diagnosed tuberculosis and is associated with poor treatment outcome despite successful tuberculosis treatment. This could be happened because of long period time that needed to consume the treatment and complexity of the drug regimen.
References
World Health Organization (WHO). Global Tuberculosis Report 2023 [Internet]. 2023. Available from: https://iris.who.int/.
Kementrian Kesehatan Republik Indonesia. https://www.kemkes.go.id/id/rilis-kesehatan/deteksi-tbc-capai-rekor-tertinggi-di-tahun-2022. 2023. Deteksi TBC Capai Rekor Tertinggi di Tahun 2022.
Pradipta IS, Houtsma D, Boven JFM van, Alffenaar JWC, Hak E. Interventions to improve medication adherence in tuberculosis patients: a systematic review of randomized controlled studies. NPJ Prim Care Respir Med. 2020 Dec 1;30(1).
World Health Organization (WHO). Consolidated Guidelines on Drug-Resistant Tuberculosis Treatment. 2019. 99 p.
Marselia R, Wilson, Pratiwi SE. Hubungan antara Lama Terapi terhadap Tingkat Gejala Depresi pada Pasien TB Paru di Unit pengobatan Penyakit Paru-Paru Pontianak. Jurnal Cerebellum. 2017;3(3):831–41.
American Psychiatric Association. Diagnostic and statistical manual of mental disorder: DSM-5. 5th ed. Washington DC: American Psychiatric Publishing; 2013.
Ambaw F, Mayston R, Hanlon C, Alem A. Depression among patients with tuberculosis: Determinants, course and impact on pathways to care and treatment outcomes in a primary care setting in southern Ethiopia - A study protocol. BMJ Open. 2015;5(7).
Yan S, Zhang S, Tong Y, Yin X, Lu Z, Gong Y. Nonadherence to Antituberculosis Medications: The Impact of stigma and depressive symptoms. American Journal of Tropical Medicine and Hygiene. 2018;98(1):262–5.
Basuki R, Budhiarti E. Pengaruh Depresi Terhadap Kepatuhan Minum OAT pada Penderita TB. Jurnal Kedokteran Muhammadiyah. 2014;3(2).
Lee GU, Lee HK. Effects of Depression, Social Support of Tuberculosis Patients on Self-care. Journal of Korean Academy of Community Health Nursing. 2022;33(4):456–64.
Duko B, Bedaso A, Ayano G. The prevalence of depression among patients with tuberculosis: A systematic review and meta-analysis. Vol. 19, Annals of General Psychiatry. BioMed Central Ltd.; 2020.
Zhang K, Wang X, Tu J, Rong H, Werz O, Chen X. The interplay between depression and tuberculosis. J Leukoc Biol. 2019 Sep 1;106(3):749–57.
Panati D, Chittooru CS, Madarapu YR, Gorantla AK. Effect of depression on treatment adherence among elderly tuberculosis patients: A prospective interventional study. Clin Epidemiol Glob Health. 2023 Jul 1;22.
Rouf A, Masoodi MA, Dar MM, Khan SMS, Bilquise R. Depression among Tuberculosis patients and its association with treatment outcomes in district Srinagar. J Clin Tuberc Other Mycobact Dis. 2021 Dec 1;25.
Grosso PR, Cachay R, Flor AD La, Schwalb A, Gil CU. Association between tuberculosis and depression on negative outcomes of tuberculosis treatment: A systematic review and meta-analysis. PLoS One. 2020 Jan 1;15(1).
Anye L, Bissong MEA, Njundah AL, Fodjo JNS. Depression, anxiety and medication adherence among tuberculosis patients attending treatment centres in Fako Division, Cameroon: cross-sectional study. BJPsych Open. 2023 May;9(3):1–9.
Wahyuni T, Cahyati WH. Multidrug Resistant Tuberkulosis (MDR-TB). HIGEIA JOURNAL OF PUBLIC HEALTH [Internet]. 2020;4(3):636–48. Available from: http://journal.unnes.ac.id/sju/index.php/higeia
Dwiningrum R, Wulandari RY, Yunitasari E. Hubungan Pengetahuan dan Lama Pengobatan TB Paru dengan Kepatuhan Minum Obat pada Pasien TB Paru Di Klinik Harum Melati. Jurnal Aisyah?: Jurnal Ilmu Kesehatan. 2021 Sep 27;6(1):209–14.
Agustin DS, Suhari, Widhiyanto A. HUBUNGAN LAMA PENGOBATAN DENGAN GANGGUAN MENTAL EMOSIONAL (GME) PADA PASIEN TB PARU DI PUSKESMAS KLAKAH LUMAJANG. Jurnal Nursing Update. 2023;14(2).
Ambaw F, Mayston R, Hanlon C, Medhin G, Alem A. Untreated depression and tuberculosis treatment outcomes, quality of life and disability, Ethiopia. Bull World Health Organ. 2018 Apr 1;96(4):243–55.
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