Analisis Determinan Kejadian Loss to Follow-up (Putus Berobat) pada Pasien Tuberkulosis Paru : Literature Review
Determinant Analysis of Loss to Follow-up Events in Pulmonary Tuberculosis Patients : Literature Review
Abstract
Latar Belakang: Tuberculosis merupakan masalah kesehatan global, ditandai dengan meningkatkan angka kesakitan dan resistensi terhadap OAT. Makin tinggi angka resisten TB searah dengan kenaikan loss to follow-up (putus berobat), karena makin banyak yang putus berobat maka pengobatan makin tidak tuntas. Dampaknya semakin memperluas angka penularan TB di masyarakat.
Tujuan: Untuk mengidentifikasi dan menganalisis faktor risiko terjadinya loss to follow-up pada pasien Tuberkulosis.
Metode: Metode menggunakan pendekatan literature review dari database Embase, Proquest, Pubmed, Scopus, dan Google Scholar, dengan keywords “determinantâ€, “loss to follow-upâ€, “putus berobatâ€, “tuberculosisâ€, dan “patientâ€, yang dilakukan dalam rentang waktu 2018-2022 dengan menerapkan kriteria inklusi dan eksklusi.
Hasil: Hasil penelusuran database diperoleh 483 artikel melalui istilah pencarian yang telah ditentukan, yang terdiri dari embase=93, proquest=105, scopus=49, pubmed=174 dan google scholar=62. Dari artikel tersebut tersaring 11 artikel yang memenuhi kriteria inklusi untuk dianalisis. Faktor-faktor yang berpengaruh terhadap kejadian loss to follow-up pada pasien tuberculosis antara lain jarak tempuh (geografis) lebih dari 10 km dan efek samping obat yang dirasakan pasien menjadikan mereka menghentikan pengobatan. Faktor dukungan keluarga, layanan pada fasilitas kesehatan, status ekonomi (finansial) merupakan faktor risiko lain yang turut berperan terhadap kejadian putus berobat.
Kesimpulan: Diketahui bahwa loss to follow-up dipengaruhi oleh berbagai faktor, antara lain 64,3% loss to follow-up berisiko terjadi pada laki-laki, jarak yang ditempuh pasien menuju pusat pengobatan berisiko terhadap loss to follow-up, selain itu efek samping yang dirasakan memperbesar risiko untuk loss to follow-up selain faktor dukungan keluarga, pelayanan kesehatan, pengetahuan, stigma, hingga kepercayaan.
References
World Health Organization. Global Tuberculosis Report 2022 [Internet]. Geneva; 2022. 68 p. Available from: https://www.ptonline.com/articles/how-to-get-better-mfi-results
World Health Organization. Regional Strategic Plan towards Ending TB in the WHO South-East Asia Region 2021-2025. 2021. 1–112 p.
Global Fund. Ending Tuberculosis is good for Business - New Initiative Launched to End Tuberculosis in the Workplace [Internet]. 2020. Available from: https://www.theglobalfund.org/en/blog/2020-01-22-ending-tuberculosis-is-good-for-business-new-initiative-launched-to-end-tuberculosis-in-the-workplace/
Kementerian Kesehatan. Strategi Nasional Penanggulangan Tuberkulosis di Indonesia 2020-2024. 2021.
Kementerian Kesehatan RI. Dashboard TBC Indonesia [Internet]. tbindonesia.or.id. 2023 [cited 2023 Feb 9]. p. 1. Available from: https://tbindonesia.or.id/pustaka-tbc/dashboard/
Aung YK, Swe PP, Kyaw Z, Thein ST. Differential loss to follow-up rates among adult tuberculosis patients – Findings from the largest private sector tuberculosis clinic database in Myanmar. PLoS One. 2019;14(6).
Watumo D, Mengesha MM, Gobena T, Gebremichael MA, Jerene D. Predictors of loss to follow-up among adult tuberculosis patients in Southern Ethiopia: a retrospective follow-up study. BMC Public Health [Internet]. 2022;22:1–12. Available from: https://www.proquest.com/scholarly-journals/predictors-loss-follow-up-among-adult/docview/2666668362/se-2
Mishra P, Sharma RK, Yadav R, Rao VG, Nigam S, Mercy AL, et al. Reasons for loss to follow-up (LTFU) of pulmonary TB (PTB) patients: A qualitative study among Saharia, a particularly vulnerable tribal group of Madhya Pradesh, India. PLoS One [Internet]. 2021 Dec;16(12). Available from: https://www.proquest.com/scholarly-journals/reasons-loss-follow-up-ltfu-pulmonary-tb-ptb/docview/2613264330/se-2
Watumo D, Mengesha MM, Gobena T, Gebremichael MA, Jerene D. Predictors of loss to follow-up among adult tuberculosis patients in Southern Ethiopia: a retrospective follow-up study. BMC Public Health. 2022;22(1).
Khaitan A, Rai SK, Krishnan A, Gupta SK, Kant S, Khilnani GC. “Better to Die Than Take These Medicinesâ€: A Community-Based Qualitative Study on the Determinants of Treatment Loss-to-Follow-Up in Tuberculosis Patients in District Faridabad, Haryana, India. Cureus. 2022 May; 14(5):e25030.
Nur Ayu Merzistya A, Ratna Rahayu S, Ilmu Kesehatan Masyarakat J, Ilmu Keolahragaan F, Negeri Semarang U. Kejadian Putus Berobat Penderita Tuberkulosis Paru. journal.unnes.ac.id [Internet]. 2019 [cited 2023 Jan 13]; Available from: https://journal.unnes.ac.id/sju/index.php/higeia/article/view/25662
World Health Organization. Drug-resistant TB [Internet]. 2022 [cited 2023 Jan 17]. Available from: https://www.who.int/teams/global-tuberculosis-programme/tb-reports/global-tuberculosis-report-2022/tb-disease-burden/2-3-drug-resistant-tb
D C. The Economic Cost of Non-adherence to TB Medicines Resulting from Stock-outs and Loss to Follow-up in Kenya. US Agency Int Dev by Syst Improv Access to Pharm Serv Progr. 2016;
Soedarsono S, Mertaniasih NM, Kusmiati T, Permatasari A, Juliasih NN, Hadi C, et al. Determinant factors for loss to follow-up in drug-resistant tuberculosis patients: the importance of psycho-social and economic aspects. BMC Pulm Med. 2021;21(1).
Andargie A, Molla A, Tadese F, Zewdie S. Lost to follow-up and associated factors among patients with drug resistant tuberculosis in Ethiopia: A systematic review and meta-analysis. PLoS One [Internet]. 2021 Mar;16(3). Available from: https://www.proquest.com/scholarly-journals/lost-follow-up-associated-factors-among-patients/docview/2502779105/se-2
Anwita K, Rai SK, Krishnan A, Gupta SK, Shashi K, Khilnani GC. “Better to Die Than Take These Medicinesâ€: A Community-Based Qualitative Study on the Determinants of Treatment Loss-to-Follow-Up in Tuberculosis Patients in District Faridabad, Haryana, India. Cureus [Internet]. 2022;14(5). Available from: https://www.proquest.com/scholarly-journals/better-die-than-take-these-medicines-community/docview/2671872751/se-2
Kim HW, Park S, Min J, Sun J, Shin AY, Ha JH, et al. Hidden loss to follow-up among tuberculosis patients managed by public–private mix institutions in South Korea. Sci Reports (Nature Publ Group) [Internet]. 2022;12(1). Available from: https://www.proquest.com/scholarly-journals/hidden-loss-follow-up-among-tuberculosis-patients/docview/2691948634/se-2
Mansour O, Masini EO, Kim B-SJ, Kamene M, Githiomi MM, Hanson CL. Impact of a national nutritional support programme on loss to follow-up after tuberculosis diagnosis in Kenya. Int J Tuberc Lung Dis [Internet]. 2018;22(6):649–54. Available from: https://www.scopus.com/inward/record.uri?eid=2-s2.0-85046955697&doi=10.5588%2Fijtld.17.0537&partnerID=40&md5=c9e28911f1b7f9f0801089f069d30fad
Mwansa-Kambafwile JRM, Jewett S, Chasela C, Ismail N, Menezes C. Initial loss to follow up of tuberculosis patients in South Africa: Perspectives of program managers. BMC Public Health. 2020;20(1).
Maharja R, Wahiduddin, Indarti Moedjiono A, Zulkifli A, Nasry Noor N, Ishak H, et al. Determinants of Loss to Follow-Up Among MDR-TB Patients. Indian J Forensic Med Toxicol. 2021; 15:3297.
Shaweno T, Getnet M, Fikru C. Does time to loss to follow-up differ among adult tuberculosis patients initiated on tuberculosis treatment and care between general hospital and health centers? A retrospective cohort study. Trop Med Health [Internet]. 2020; 48:1–11. Available from: https://www.proquest.com/scholarly-journals/does-time-loss-follow-up-differ-among-adult/docview/2547578437/se-2
Kementerian Kesehatan. Peraturan Menteri Kesehatan RI Nomor HK.01.07/Menkes/755/2019. 2019.
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