Risiko Infeksi COVID-19 pada Tenaga Kesehatan di Rumah Sakit dengan Riwayat Infeksi atau Vaksinasi COVID-19: Systematic Review
Risk of COVID-19 Infection Among Healthcare Workers in Hospitals with Previous Infection or Vaccination: A Systematic Review
Abstract
Pandemi COVID-19 telah berlangsung selama lebih dari 1 tahun mengakibatkan beban signifikan kepada rumah sakit dan tenaga kesehatan yang memiliki risiko paparan virus SARS-COV-2 tertinggi. Berbagai upaya pencegahan transmisi COVID 19 sudah dilakukan, salah satunya adalah program vaksinasi. Walaupun tingkat kematian dan morbiditas akibat COVID-19 telah berkurang secara signifikan, ada semakin banyak laporan yang menyatakan adanya risiko infeksi ulang pada individu yang telah sembuh dari COVID-19 ataupun telah di vaksinasi. Penelitian ini bertujuan untuk mengevaluasi pengaruh riwayat infeksi COVID-19 atau vaksinasi terhadap angka kejadian infeksi COVID-19 pada tenaga kesehatan khususnya di rumah sakit. Pencarian literatur dilakukan secara sistematis menggunakan kata kunci dilakukan pada 4 database online selama Maret 2020 hingga Juni 2021. Setelah itu, dilakukan penilaian risiko bias dan pengambilan kesimpulan. Dari 10 studi yang didapatkan menunjukkan hasil yang konsisten bahwa infeksi atau vaksinasi COVID-19 sebelumnya dapat mengurangi risiko infeksi di masa yang akan datang. Namun beberapa studi masih menunjukkan angka infeksi COVID-19 setelah vaksinasi dosis kedua ataupun infeksi COVID-19 sebelumnya. Disimpulkan bahwa riwayat infeksi COVID-19 atau vaksinasi sebelumnya mengurangi risiko infeksi COVID-19 selanjutnya tetapi tenaga kesehatan yang sudah divaksinasi tetap berisiko tertular infeksi SARS-COV-2, sehingga perlu pertimbangan untuk revaksinasi dalam memberikan perlindungan terhadap varian baru yang mungkin akan muncul.
References
The Visual and Data Journalism Team of BBC. Covid-19 Pandemic: Tracking The Global Coronavirus Outbreak. 2021.
di Mauro Gabriella, Cristina S, Concetta R, Francesco R, Annalisa C. SARS-Cov-2 infection: Response of human immune system and possible implications for the rapid test and treatment. Int Immunopharmacol. 2020 Jul;84:106519.
BPOM. Penerbitan Persetujuan Penggunaan Dalam Kondisi Darurat Atau Emergency Use Authorization (EUA) Pertama Untuk Vaksin COVID-19. Badan Pengawas Obat dan Makanan - Republik Indonesia. 2021.
CDC. COVID-19 Vaccine EUA Recipient/Caregiver Fact Sheets. Centers for Disease Control and Prevention. 2021.
WHO. Tracking SARS-CoV-2 variants. World Health Organization. 2021.
PRISMA. 2020.
Wolff R, Westwood M, Kleijnen J. Risk of bias criteria for prognostic studies Quality assessment of prognostic studies. Eur Respir J. 2016 Aug;
Cucunawangsih C, Wijaya RS, Lugito NPH, Suriapranata I. Post-vaccination cases of COVID-19 among healthcare workers at Siloam Teaching Hospital, Indonesia. Int J Infect Dis. 2021 Jun;107:268–70.
Pilishvili T, Fleming-Dutra KE, Farrar JL, Gierke R, Mohr NM, Talan DA, et al. Interim Estimates of Vaccine Effectiveness of Pfizer-BioNTech and Moderna COVID-19 Vaccines Among Health Care Personnel — 33 U.S. Sites, January–March 2021. MMWR Recomm Reports. 2021;70(20):753–8.
Jones NK, Rivett L, Seaman S, Samworth RJ, Warne B, Workman C, et al. Single-dose bnt162b2 vaccine protects against asymptomatic sars-cov-2 infection. Elife. 2021;10.
Thompson MG, Burgess JL, Naleway AL, Tyner HL, Yoon SK, Meece J, et al. Interim Estimates of Vaccine Effectiveness of BNT162b2 and mRNA-1273 COVID-19 Vaccines in Preventing SARS-CoV-2 Infection Among Health Care Personnel, First Responders, and Other Essential and Frontline Workers — Eight U.S. Locations, December 2020–March 2021. MMWR Morb Mortal Wkly Rep. 2021 Apr;70(13):495–500.
Eyre DW, Lumley SF, Wei J, Cox S, James T, Justice A, et al. Quantitative SARS-CoV-2 anti-spike responses to Pfizer-BioNTech and Oxford-AstraZeneca vaccines by previous infection status. Clin Microbiol Infect. 2021 Jun;
Cavanaugh AM, Fortier S, Lewis P, Arora V, Johnson M, George K, et al. COVID-19 Outbreak Associated with a SARS-CoV-2 R.1 Lineage Variant in a Skilled Nursing Facility After Vaccination Program — Kentucky, March 2021. MMWR Morb Mortal Wkly Rep. 2021 Apr;70(17):639–43.
Shah AS V, Gribben C, Bishop J, Hanlon P, Caldwell D, Wood R, et al. Effect of vaccination on transmission of COVID-19: an observational study in healthcare workers and their households. medRxiv. 2021 Mar;2021.03.11.21253275.
Lumley SF, O’Donnell D, Stoesser NE, Matthews PC, Howarth A, Hatch SB, et al. Antibody Status and Incidence of SARS-CoV-2 Infection in Health Care Workers. N Engl J Med. 2021 Feb;384(6):533–40.
Ejm M, Study Group S. Do antibody positive healthcare workers have lower SARS-CoV-2 infection rates than antibody negative healthcare workers? Large multi-centre prospective cohort study (the SIREN study), England: June to November 2020. medRxiv. 2021;
Saadat S, Zahra ;, Tehrani R, Logue J, Newman M, Frieman MB, et al. Single Dose Vaccination in Healthcare Workers Previously Infected with SARS-CoV-2. medRxiv. 2021;
Hall VJ, Foulkes S, Charlett A, Atti A, Monk EJM, Simmons R, et al. SARS-CoV-2 infection rates of antibody-positive compared with antibody-negative health-care workers in England: a large, multicentre, prospective cohort study (SIREN). Lancet. 2021 Apr;397(10283):1459–69.
Authors who publish with Journal of Public Health and Pharmacy retain the copyright of their work. The journal applies a Creative Commons Attribution-ShareAlike 4.0 International License (CC BY-SA 4.0), which grants the following rights:
-
Copyright Retention: Authors retain the copyright of their work, maintaining full control over their intellectual property without restrictions.
-
Right of First Publication: Authors grant the journal the right of first publication of their work. This ensures that the work is initially published and credited in Journal of Public Health and Pharmacy.
-
License to Share and Reuse: The work is licensed under CC BY-SA 4.0, allowing others to copy, distribute, remix, and build upon the work for any purpose, even commercially, as long as proper credit is given to the authors, and any new creations are licensed under the same terms.