Factors Affecting Medication Compliance of Patients with Schizophrenia at the Psychiatric Polyclinic of Dr. Mm Dunda Limboto Hospital
Keywords:
Medication Adherence, Patients with Schizophrenia, Psychiatric Clinic of Dr. MM Dunda Limboto Hospital
Abstract
Schizophrenia is a serious mental disorder that affects the way a person thinks, feels, and acts. This disorder is characterized by psychotic symptoms such as hallucinations, delusions, thinking disorders, and social withdrawal. This study uses a cross sectional design. Cross-sectional is a design that aims to find an event in a phenomenon, situation, problem, behavior, or issue by taking a cross-section (representative example representing the whole) of a population. There was no long-term relationship between treatment and medication adherence for schizophrenia patients at the Psychiatric Polyclinic of MM Dunda Limboto Hospital with the results of the chi square statistical test showing a p-value = 0.061 (>0.05). There was a relationship between family knowledge and medication adherence for schizophrenia patients at the Psychiatric Polyclinic of MM Dunda Limboto Hospital with the results of the chi square statistical test showing a p-value = 0.011 (<0.05). There was a relationship between family support and medication adherence to schizophrenia patients at the Psychiatric Polyclinic of MM Dunda Limboto Hospital with the results of the chi square statistical test showing a p-value = 0.002 (<0.05).
References
Agustini, M., Indrayadi, I., & Oktavia, I. (2023). Family Psychoeducation and Family Ability to Care for Family Members With Schizophrenia: A Literature Review. Preventive Promotive Journal, 6(2), 107–116. https://doi.org/10.47650/jpp.v6i2.803
Alfiannoor. (2022). The Long Relationship between Treatment and Medication Adherence in Hypertension Patients in the Working Area of the Danau Panggang Health Center UPT. Sari Mulia University Banjarmasin.
American Psychiatric Association (APA). (2020). The American Psychiatric Association Practice Guideline for the Treatment of Patients With Schizophrenia. American Journal of Psychiatry, 177(9), 868–872. https://doi.org/10.1176/appi.ajp.2020.177901
Amin, N. F., Gaplan, S., & Abunawas, K. (2023). General Concepts of Population and Sample in Research. PILLARS, 14(1), 15–31.
Amna, N., Marthoenis, M., & Syarif, H. (2023). The Female Indonesian Outpatients with Schizophrenia Adherence to Antipsychotics Medication. In Public Health (pp. 409–412). Faculty of Nursing, Syiah Kuala University.
Aodina, F. W. (2020). Utilization of chronic disease management programs. Higeia Journal of Public Health Research and Development, 4(Special 4), 864–874.
Aremu, T. O., Oluwole, O. E., Adeyinka, K. O., & Schommer, J. C. (2022). Medication Adherence and Compliance: Recipe for Improving Patient Outcomes. Pharmacy, 10(5), 106. https://doi.org/10.3390/pharmacy10050106
Ayu Handayani, F. (2021). LITERATURE REVIEW: GROUP ACTIVITY THERAPY IN PEOPLE WITH SCHIZOPHRENIA WITH SENSORY PERCEPTION DISORDERS OF VISUAL HALLUCINATIONS. University of Muhammadiyah Ponorogo.
Azizah, L. M., Zainuri, I., & Akbar, A. (2016). Textbook of mental health nursing, theory and application of clinical practice. Indomedia Pustaka.
Boyd, M. . (2018). Psychiatric Nursing: Contemporary Practice (6th ed). Wolters Kluwer.
Correll, C. U., Martin, A., Patel, C., Benson, C., Goulding, R., Kern-Sliwa, J., Joshi, K., Schiller, E., & Kim, E. (2022). Systematic literature review of schizophrenia clinical practice guidelines on acute and maintenance management with antipsychotics. Schizophrenia, 8(1), 1–10. https://doi.org/10.1038/s41537-021-00192-x
Dervish. (2020). The Relationship between Family Knowledge Level and Medication Compliance of Schizophrenia Patients at the Psychiatric Polyclinic of Salewangan Maros Hospital. Scientific Journal of Health Diagnosis, 15, 321–326.
Eddy, F. N. E., Septa, T., & Angraini, D. I. (2017). Diagnosis and Management of Discontinued Hebrew Schizophrenia with Logorrhea. Journal of Medula, 7(3).
Edi, I. G. M. S. (2020). Factors that affect patient adherence to treatment. Scientific Journal of Medicine, 1(1), 1–8. https://doi.org/10.36733/medicamento.v1i1.719
Elvira, S. D., & Hadisukanto, G. (2017). Third Edition of the Psychiatric Textbook. Jakarta: FKUI Publishing Agency.
Fauzy, A. (2019). Sampling Method. In Open University (Vol. 9, Issue 1).
Guo, J., Lv, X., Liu, Y., Kong, L., Qu, H., & Yue, W. (2023). Influencing factors of medication adherence in schizophrenic patients: a meta-analysis. Schizophrenia, 9(1), 23–25. https://doi.org/10.1038/s41537-023-00356-x
Gupta, T., Horton, W. S., Haase, C. M., Carol, E. E., & Mittal, V. A. (2023). Clues from caregiver emotional language usage highlight the link between putative social environment and the psychosis-risk syndrome. Schizophrenia Research, 259, 4–10. https://doi.org/https://doi.org/10.1016/j.schres.2022.03.012
Islam, M. A., Nisa, Z. U., Almuzel, A. I., Al Afif, H. S., Al Rabia, L. H., Iqbal, M. S., Ishaqui, A. A., Iqbal, M. Z., Hossain, M. A., Haseeb, A., Jamshed, S., Naqvi, A. A., & Kripalani, S. (2021). Concurrent validity of the Arabic version of General Medication Adherence Scale using two validated indirect adherences measures in Saudi patients with non-communicable diseases. Saudi Pharmaceutical Journal, 29(8), 874–878. https://doi.org/10.1016/j.jsps.2021.07.002
Isnani, N., & Putra, R. A. A. H. S. (2020). The relationship between medication adherence to the recurrence rate of schizophrenia patients in the psychiatric hospital poly. Dr. H. Moch. Ansari Saleh Banjarmasin. Journal of Scientific Studies of Health and Technology, 2(1), 35–39.
Ministry of Health. (2023). Indonesian Health Survey 2023 (SKI). Ministry of Health, 235.
Ministry of Health of the Republic of Indonesia. (2024). Combination of Psychotic Drugs and Psychological Therapy for Schizophrenic Patients. http://yankes.kemkes.go.id/readkombinasi-%0Aobat-psikotik-dan-terapipsikologis-%0Auntuk-pasien-skizofrenia-%0A7106.html
Kinanti, A. D., Lisum, K., & Supardi, S. (2025). Correlation of Length of Treatment and Family Support to Medication Adherence to Anti-Tuberculosis Medications. 20(03), 223–228.
Livana, P. H., Ruhimat, I. I. A., Sujarwoo, S., Suerni, T., Kandar, K., Maya, A., & Nugroho, A. (2020). Improving Patients' Ability to Control Hallucinations through Perception Stimulation Group Activity Therapy. Journal of Nurses Widya Husada, 5(1), 35–40.
Ljungdalh, P. M. (2017). Non-adherence to pharmacological treatment in schizophrenia and schizophrenia spectrum disorders – An updated systematic literature review. European Journal of Psychiatry, 31(4), 172–186. https://doi.org/10.1016/j.ejpsy.2017.08.001
Loots, E., Goossens, E., Vanwesemael, T., Morrens, M., Van Rompaey, B., & Dilles, T. (2021). Interventions to improve medication adherence in patients with schizophrenia or bipolar disorders: A systematic review and meta-analysis. International Journal of Environmental Research and Public Health, 18(19). https://doi.org/10.3390/ijerph181910213
Merlis, S., & Alfiah. (2022). The Relationship Between the Length of Suffering from Hypertension and Motivation to Seek Treatment and Medication Adherence in Hypertensive Patients. Nursing Inside Community, 5(1), 1–5.
Mochsal, T. A., Destya, C., Putri, R., Wicaksono, Y. I., Anisa, R., Medicine, F., Islam, U., Timur, J., Mochsal, T. A., Destya, C., Putri, R., Wicaksono, Y. I., Anisa, R., & Hospital, R. W. (2024). Analysis of Internal Factors and Psychosocial Factors on the Relapse of Schizophrenia Patients at Dr. Radjiman Wediodiningrat Mental Hospital. 1–10.
Notoatmodjo, S. (2018). Health Research Methodology (3rd). Rineka Cipta.
Nuraini, H. (2019). Determinants of Family Compliance in Assisting the Treatment of Schizophrenia Patients in Patient Areas in the Urban Health Center Area of Jember Regency. Thesis.
Panjaitan, L. N., & Dewi, B. P. (2020). Factors influencing the recurrence of patients with mental disorders: a literature review. Journal of Health and Development, 12(23), 21–34.
Pardede, J. A., Harjuliska, H., & Ramadia, A. (2021). Self-Efficacy and Family Roles Relate to the Frequency of Relapse in Schizophrenia Patients. Journal of Psychiatric Nursing Sciences, 4(1), 57–66.
Pasaribu, B., Herawati, A., Utomo, K. W., & Aji, R. H. S. (2022). Research Methodology for Economics and Business.
Putra, R. S., Italy, & Kartini. (2024). Factors Related to Medication Compliance for Schizophrenia Patients at the Psychiatric Poly of the Keramasan Palembang Health Center in 2024. Chemistry, 5(2), 3737–3749.
Rahayu, E., Zainuri, I., & Ningsih, A. (2023). The Relationship of Family Support with Medication Compliance of Schizophrenic Patients in the Working Area of the Kedundung City Health Center. 8, 40997–41003. https://repositori.ubs-ppni.ac.id/handle/123456789/1880
Randy Refnandes, & Zakiah Almaya. (2022). Characteristics and factors influencing medication adherence in schizophrenic patients. Journal of Medical Sciences Research, 1(2), 01–11. https://doi.org/10.55606/jurrike.v1i2.367
Saat, S., & Mania, S. (2019). Introduction to Research Methodology : A Guide for Beginner Researchers. The Legacy of Almaida.
Saputra, D. R., Rahmawati, A. N., & ... (2024). Overview of the Level of Family Knowledge and Attitudes in Prevention of Relapse in Schizophrenic Patients. Journal of Education ..., 12(2), 494–500. https://journal.ipts.ac.id/index.php/ED/article/view/5792%0Ahttps://journal.ipts.ac.id/index.php/ED/article/download/5792/3305
Sari. (2019). The Effect of Family Psychoeducation Therapy on the Burden and Ability of Families to Care for Pasung Clients in Bireuen Nanggroe Regency, Aceh Darusalam. University of Indonesia.
Sarwono, A. E., & Handayani, A. (2021). Quantitative Method of the Author.
Setyawan, D. A. (2021). Hypotheses and research variables. In Tahta Media Group.
Singh, S., Khanna, D., & Kalra, S. (2020). Role of neurochemicals in schizophrenia. Current Psychopharmacology, 9(2), 144–161.
Stuart, G. W. (2016). Adaptive stress models in psychiatric nursing. A Pocket Book of Psychiatry. EGC.
Stuart, G. W. (2020). Principles and Practice of Psychiatric Nursing. Elsevier.
Susanti, D., Paramita, P., & Antaria, A. (2022). Analysis of Medication Compliance Factors for Schizophrenia Patients at Poli Mentari Health Center, Kalideres District (Sikda Data Analysis in 2019). Indonesian Journal of Public Health, 17(1), 25. https://doi.org/10.26714/jkmi.17.1.2022.25-31
Sutejo. (2018). Mental Health Nursing. New Library Press.
Vasanthan, M., Siva, R., Raju, S. B., & Saranya, G. (2025). A Pilot Study Evaluating Medication Adherence in Geriatric Patients with Chronic Conditions. Asian Journal of Advanced Research and Reports, 1(19), 29–10. https://doi.org/https://doi.org/10.9734/ajarr/2025/v19i1859
Videbeck, S. . (2020). Psychiatric-Mental Health Nursing (7th ed.). Wolters Kluwer.
WHO. (2022). Schizophrenia. In World Health Organization. https://www.who.int/news-room/fact-sheets/detail/schizophrenia
Yacob, R., Ilham, R., Syamsuddin, F., Study, P., Nursing, I., Gorontalo, U. M., & Gorontalo, K. (2023). THE RELATIONSHIP BETWEEN MEDICATION ADHERENCE TO MEDICATION AND BLOOD PRESSURE REDUCTION IN HYPERTENSIVE PATIENTS OF THE PROLANIS PROGRAM IN THE WORK AREA OF THE TAPA HEALTH CENTER. 1(2), 58–67.
Yeni, K., Yolanda, M., & Ahmalia, R. (2023). The Relationship of Family Support with the Relapse of Outpatient Schizophrenia Patients at Padang Pariaman Hospital. Health and Nursing Centers ..., 19–22.
Alfiannoor. (2022). The Long Relationship between Treatment and Medication Adherence in Hypertension Patients in the Working Area of the Danau Panggang Health Center UPT. Sari Mulia University Banjarmasin.
American Psychiatric Association (APA). (2020). The American Psychiatric Association Practice Guideline for the Treatment of Patients With Schizophrenia. American Journal of Psychiatry, 177(9), 868–872. https://doi.org/10.1176/appi.ajp.2020.177901
Amin, N. F., Gaplan, S., & Abunawas, K. (2023). General Concepts of Population and Sample in Research. PILLARS, 14(1), 15–31.
Amna, N., Marthoenis, M., & Syarif, H. (2023). The Female Indonesian Outpatients with Schizophrenia Adherence to Antipsychotics Medication. In Public Health (pp. 409–412). Faculty of Nursing, Syiah Kuala University.
Aodina, F. W. (2020). Utilization of chronic disease management programs. Higeia Journal of Public Health Research and Development, 4(Special 4), 864–874.
Aremu, T. O., Oluwole, O. E., Adeyinka, K. O., & Schommer, J. C. (2022). Medication Adherence and Compliance: Recipe for Improving Patient Outcomes. Pharmacy, 10(5), 106. https://doi.org/10.3390/pharmacy10050106
Ayu Handayani, F. (2021). LITERATURE REVIEW: GROUP ACTIVITY THERAPY IN PEOPLE WITH SCHIZOPHRENIA WITH SENSORY PERCEPTION DISORDERS OF VISUAL HALLUCINATIONS. University of Muhammadiyah Ponorogo.
Azizah, L. M., Zainuri, I., & Akbar, A. (2016). Textbook of mental health nursing, theory and application of clinical practice. Indomedia Pustaka.
Boyd, M. . (2018). Psychiatric Nursing: Contemporary Practice (6th ed). Wolters Kluwer.
Correll, C. U., Martin, A., Patel, C., Benson, C., Goulding, R., Kern-Sliwa, J., Joshi, K., Schiller, E., & Kim, E. (2022). Systematic literature review of schizophrenia clinical practice guidelines on acute and maintenance management with antipsychotics. Schizophrenia, 8(1), 1–10. https://doi.org/10.1038/s41537-021-00192-x
Dervish. (2020). The Relationship between Family Knowledge Level and Medication Compliance of Schizophrenia Patients at the Psychiatric Polyclinic of Salewangan Maros Hospital. Scientific Journal of Health Diagnosis, 15, 321–326.
Eddy, F. N. E., Septa, T., & Angraini, D. I. (2017). Diagnosis and Management of Discontinued Hebrew Schizophrenia with Logorrhea. Journal of Medula, 7(3).
Edi, I. G. M. S. (2020). Factors that affect patient adherence to treatment. Scientific Journal of Medicine, 1(1), 1–8. https://doi.org/10.36733/medicamento.v1i1.719
Elvira, S. D., & Hadisukanto, G. (2017). Third Edition of the Psychiatric Textbook. Jakarta: FKUI Publishing Agency.
Fauzy, A. (2019). Sampling Method. In Open University (Vol. 9, Issue 1).
Guo, J., Lv, X., Liu, Y., Kong, L., Qu, H., & Yue, W. (2023). Influencing factors of medication adherence in schizophrenic patients: a meta-analysis. Schizophrenia, 9(1), 23–25. https://doi.org/10.1038/s41537-023-00356-x
Gupta, T., Horton, W. S., Haase, C. M., Carol, E. E., & Mittal, V. A. (2023). Clues from caregiver emotional language usage highlight the link between putative social environment and the psychosis-risk syndrome. Schizophrenia Research, 259, 4–10. https://doi.org/https://doi.org/10.1016/j.schres.2022.03.012
Islam, M. A., Nisa, Z. U., Almuzel, A. I., Al Afif, H. S., Al Rabia, L. H., Iqbal, M. S., Ishaqui, A. A., Iqbal, M. Z., Hossain, M. A., Haseeb, A., Jamshed, S., Naqvi, A. A., & Kripalani, S. (2021). Concurrent validity of the Arabic version of General Medication Adherence Scale using two validated indirect adherences measures in Saudi patients with non-communicable diseases. Saudi Pharmaceutical Journal, 29(8), 874–878. https://doi.org/10.1016/j.jsps.2021.07.002
Isnani, N., & Putra, R. A. A. H. S. (2020). The relationship between medication adherence to the recurrence rate of schizophrenia patients in the psychiatric hospital poly. Dr. H. Moch. Ansari Saleh Banjarmasin. Journal of Scientific Studies of Health and Technology, 2(1), 35–39.
Ministry of Health. (2023). Indonesian Health Survey 2023 (SKI). Ministry of Health, 235.
Ministry of Health of the Republic of Indonesia. (2024). Combination of Psychotic Drugs and Psychological Therapy for Schizophrenic Patients. http://yankes.kemkes.go.id/readkombinasi-%0Aobat-psikotik-dan-terapipsikologis-%0Auntuk-pasien-skizofrenia-%0A7106.html
Kinanti, A. D., Lisum, K., & Supardi, S. (2025). Correlation of Length of Treatment and Family Support to Medication Adherence to Anti-Tuberculosis Medications. 20(03), 223–228.
Livana, P. H., Ruhimat, I. I. A., Sujarwoo, S., Suerni, T., Kandar, K., Maya, A., & Nugroho, A. (2020). Improving Patients' Ability to Control Hallucinations through Perception Stimulation Group Activity Therapy. Journal of Nurses Widya Husada, 5(1), 35–40.
Ljungdalh, P. M. (2017). Non-adherence to pharmacological treatment in schizophrenia and schizophrenia spectrum disorders – An updated systematic literature review. European Journal of Psychiatry, 31(4), 172–186. https://doi.org/10.1016/j.ejpsy.2017.08.001
Loots, E., Goossens, E., Vanwesemael, T., Morrens, M., Van Rompaey, B., & Dilles, T. (2021). Interventions to improve medication adherence in patients with schizophrenia or bipolar disorders: A systematic review and meta-analysis. International Journal of Environmental Research and Public Health, 18(19). https://doi.org/10.3390/ijerph181910213
Merlis, S., & Alfiah. (2022). The Relationship Between the Length of Suffering from Hypertension and Motivation to Seek Treatment and Medication Adherence in Hypertensive Patients. Nursing Inside Community, 5(1), 1–5.
Mochsal, T. A., Destya, C., Putri, R., Wicaksono, Y. I., Anisa, R., Medicine, F., Islam, U., Timur, J., Mochsal, T. A., Destya, C., Putri, R., Wicaksono, Y. I., Anisa, R., & Hospital, R. W. (2024). Analysis of Internal Factors and Psychosocial Factors on the Relapse of Schizophrenia Patients at Dr. Radjiman Wediodiningrat Mental Hospital. 1–10.
Notoatmodjo, S. (2018). Health Research Methodology (3rd). Rineka Cipta.
Nuraini, H. (2019). Determinants of Family Compliance in Assisting the Treatment of Schizophrenia Patients in Patient Areas in the Urban Health Center Area of Jember Regency. Thesis.
Panjaitan, L. N., & Dewi, B. P. (2020). Factors influencing the recurrence of patients with mental disorders: a literature review. Journal of Health and Development, 12(23), 21–34.
Pardede, J. A., Harjuliska, H., & Ramadia, A. (2021). Self-Efficacy and Family Roles Relate to the Frequency of Relapse in Schizophrenia Patients. Journal of Psychiatric Nursing Sciences, 4(1), 57–66.
Pasaribu, B., Herawati, A., Utomo, K. W., & Aji, R. H. S. (2022). Research Methodology for Economics and Business.
Putra, R. S., Italy, & Kartini. (2024). Factors Related to Medication Compliance for Schizophrenia Patients at the Psychiatric Poly of the Keramasan Palembang Health Center in 2024. Chemistry, 5(2), 3737–3749.
Rahayu, E., Zainuri, I., & Ningsih, A. (2023). The Relationship of Family Support with Medication Compliance of Schizophrenic Patients in the Working Area of the Kedundung City Health Center. 8, 40997–41003. https://repositori.ubs-ppni.ac.id/handle/123456789/1880
Randy Refnandes, & Zakiah Almaya. (2022). Characteristics and factors influencing medication adherence in schizophrenic patients. Journal of Medical Sciences Research, 1(2), 01–11. https://doi.org/10.55606/jurrike.v1i2.367
Saat, S., & Mania, S. (2019). Introduction to Research Methodology : A Guide for Beginner Researchers. The Legacy of Almaida.
Saputra, D. R., Rahmawati, A. N., & ... (2024). Overview of the Level of Family Knowledge and Attitudes in Prevention of Relapse in Schizophrenic Patients. Journal of Education ..., 12(2), 494–500. https://journal.ipts.ac.id/index.php/ED/article/view/5792%0Ahttps://journal.ipts.ac.id/index.php/ED/article/download/5792/3305
Sari. (2019). The Effect of Family Psychoeducation Therapy on the Burden and Ability of Families to Care for Pasung Clients in Bireuen Nanggroe Regency, Aceh Darusalam. University of Indonesia.
Sarwono, A. E., & Handayani, A. (2021). Quantitative Method of the Author.
Setyawan, D. A. (2021). Hypotheses and research variables. In Tahta Media Group.
Singh, S., Khanna, D., & Kalra, S. (2020). Role of neurochemicals in schizophrenia. Current Psychopharmacology, 9(2), 144–161.
Stuart, G. W. (2016). Adaptive stress models in psychiatric nursing. A Pocket Book of Psychiatry. EGC.
Stuart, G. W. (2020). Principles and Practice of Psychiatric Nursing. Elsevier.
Susanti, D., Paramita, P., & Antaria, A. (2022). Analysis of Medication Compliance Factors for Schizophrenia Patients at Poli Mentari Health Center, Kalideres District (Sikda Data Analysis in 2019). Indonesian Journal of Public Health, 17(1), 25. https://doi.org/10.26714/jkmi.17.1.2022.25-31
Sutejo. (2018). Mental Health Nursing. New Library Press.
Vasanthan, M., Siva, R., Raju, S. B., & Saranya, G. (2025). A Pilot Study Evaluating Medication Adherence in Geriatric Patients with Chronic Conditions. Asian Journal of Advanced Research and Reports, 1(19), 29–10. https://doi.org/https://doi.org/10.9734/ajarr/2025/v19i1859
Videbeck, S. . (2020). Psychiatric-Mental Health Nursing (7th ed.). Wolters Kluwer.
WHO. (2022). Schizophrenia. In World Health Organization. https://www.who.int/news-room/fact-sheets/detail/schizophrenia
Yacob, R., Ilham, R., Syamsuddin, F., Study, P., Nursing, I., Gorontalo, U. M., & Gorontalo, K. (2023). THE RELATIONSHIP BETWEEN MEDICATION ADHERENCE TO MEDICATION AND BLOOD PRESSURE REDUCTION IN HYPERTENSIVE PATIENTS OF THE PROLANIS PROGRAM IN THE WORK AREA OF THE TAPA HEALTH CENTER. 1(2), 58–67.
Yeni, K., Yolanda, M., & Ahmalia, R. (2023). The Relationship of Family Support with the Relapse of Outpatient Schizophrenia Patients at Padang Pariaman Hospital. Health and Nursing Centers ..., 19–22.
Published
2026-01-05
How to Cite
Indrawaty Djakatara, Fadli Syamsuddin, & Nur Uyuun I. Biahimo. (2026). Factors Affecting Medication Compliance of Patients with Schizophrenia at the Psychiatric Polyclinic of Dr. Mm Dunda Limboto Hospital. International Journal of Health, Economics, and Social Sciences (IJHESS), 8(1), 126~136. https://doi.org/10.56338/ijhess.v8i1.9435
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