The Effect of Hemodialysis Therapy on Blood Glucose Levels in Patients in the Hemodialysis Room Prof. Dr. H. Aloei Saboe General Hospital Gorontalo City
Keywords:
Chronic Kidney Disease, Hemodialysis Therapy, Blood Glucose Levels
Abstract
Hemodialysis generally functions to remove metabolic waste products that cause a decrease in blood glucose levels. The purpose of this study was to determine the effect of hemodialysis therapy on blood glucose levels in patients in the hemodialysis room at Prof. Dr. H. Aloei Saboe Regional General Hospital in Gorontalo City.
The research method used was quantitative research with a quasi-experimental design and a one-group pre-post test design. The sample consisted of 26 respondents using purposive sampling technique.
The Wilcoxon test yielded a p-value of 0.000 (p-value < 0.05), indicating that hemodialysis therapy affects blood glucose levels in patients in the hemodialysis room at Prof. Dr. H. Aloei Saboe Regional General Hospital in Gorontalo City. Hemodialysis therapy can reduce the burden of uremic toxins that previously interfered with insulin sensitivity. After dialysis, cellular response to insulin improves, allowing blood glucose levels to be controlled more effectively. It is hoped that this will yield positive results in enhancing the quality of nursing care for patients undergoing hemodialysis therapy, particularly in measuring blood glucose levels. Hemodialysis therapy should be performed to measure blood glucose levels.
References
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33. Rahayu, S., & Siregar, D. (2023). Analisis kadar glukosa darah sebelum dan sesudah hemodialisis pada pasien penyakit ginjal kronis. Jurnal Keperawatan Indonesia, 26(1), 33–41.
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38. Saragih, D. (2022). Fluktuasi kadar glukosa darah pada pasien diabetes melitus yang menjalani hemodialisis. Jurnal Kesehatan Indonesia, 18(4), 89–97.
39. Sembiring, T., Irmawati, Sabir, M., & Tjahyadi, I. (2023). Buku Ajar Metodologi Penelitian (Teori dan Praktik). CV. Saba Jaya Publisher.
40. Shi, Y., Wang, T., Ding, Z., Yan, L., Yao, C., & Qian, H. (2025). Frequent hypoglycemia during hemodialysis in ESRD patients leads to higher risk of death. Renal Failure, 47(1), 2484471.
41. Siregar, L. (2022). Perubahan kadar glukosa darah pada pasien hemodialisis dengan diabetes mellitus. Jurnal Ilmiah Keperawatan Indonesia, 9(3), 120–129.
42. Tan, J., Li, M., Xu, Y., Chen, X., & Zhou, Y. (2021). Glycemic patterns and factors associated with post-hemodialysis hyperglycemia in diabetic patients: A continuous glucose monitoring study. Endocrine Journal, 68(3), 321–329.
43. Thomas, M. C. (2020). Insulin resistance and kidney disease. Clinical Journal of the American Society of Nephrology, 15(7), 1024–1032.
44. Wahyuni, D. (2021). Perubahan Kadar Gula Darah Sebelum dan Sesudah Hemodialisa pada Pasien Gagal Ginjal Kronik. Jurnal Keperawatan, 13(1), 25–31.
45. Wang, Y., Liu, Q., & Chen, H. (2019). Effects of glucose-containing dialysate on glycemic levels in dialysis patients. International Journal of Nephrology, 24(1), 55–63.
46. Zhang, Y., & Li, X. (2020). Glycemic variation and metabolic response in chronic kidney disease patients undergoing hemodialysis. Journal of Clinical Dialysis, 15(4), 211–219.
2. Ambarita, S. (2022). Analisis kadar glukosa darah sebelum dan sesudah tindakan hemodialisa pada penderita gagal ginjal kronik di Rumah Sakit Santa Elisabeth Medan Tahun 2022 (Skripsi). STIKes Santa Elisabeth Medan.
3. American Diabetes Association. (2022). Standards of medical care in diabetes—2022. Diabetes Care, 45(Suppl 1), S1–S102.
4. American Diabetes Association. (2024). Standards of medical care in diabetes—2024. Diabetes Care, 47(Supplement 1), S1–S200.
5. Anggreni, D. (2022). Buku Ajar: Metodologi Penelitian Kesehatan. Jawa Timur: STIKes Majapahit Mojokerto.
6. Banasik, J. L., Copstead, L. E. (2019). Pathophysiology (6th ed.). Elsevier.
7. Damanik, T. (2020). Pola perubahan kadar glukosa darah pada pasien penyakit ginjal kronis yang menjalani hemodialisis. Jurnal Klinik Indonesia, 9(2), 112–120.
8. Dewita Sari, P. A. (2021). Perbandingan kadar glukosa darah sewaktu pra dan pasca hemodialisis pada pasien diabetes melitus tipe 2 dengan kondisi gagal ginjal kronik (Skripsi). Universitas Binawan.
9. Garaika., & Darmanah. (2019). Metodologi Penelitian. Lampung : CV HIRA TECH.
10. Global Burden of Disease Study. (2019). GBD Results Tool.
11. Guyton, A. C., & Hall, J. E. (2017). Textbook of Medical Physiology (13th ed.). Elsevier.
12. Hammer, G. D., & McPhee, S. J. (2019). Pathophysiology of disease: An introduction to clinical medicine (8th ed.). McGraw-Hill Education.
13. Handryastuti, S., & Pardede, S. O. (2020). Penyakit ginjal kronik pada anak. Sagung Seto.
14. Hassan, A., & Omar, H. (2021). Physiological stress response and glycemic instability during hemodialysis. Journal of Renal Medicine, 18(2), 102–110.
15. Huang, C. T., Lin, L. Y., Yang, K. C., & Hsu, B. G. (2020). Glycemic fluctuations and hypoglycemia risk during hemodialysis in diabetic patients. BMC Nephrology, 21(1), 112.
16. Indonesian Renal Registry. (2022). 9th Report of Indonesian Renal Registry. Perhimpunan Nefrologi Indonesia.
17. Kaviani, S., Rahimi, M., & Goudarzi, Z. (2020). Effect of glucose-containing dialysate on blood glucose variation in hemodialysis patients. International Journal of Nephrology and Endocrinology, 7(1), 44–51.
18. Kementerian Kesehatan RI. (2022). Pedoman Pelayanan Hemodialisis di Fasilitas Kesehatan. Jakarta: Direktorat P2PTM.
19. Kementerian Kesehatan RI. (2022). Pedoman Pencegahan dan Pengendalian Penyakit Ginjal Kronik di Indonesia. Jakarta: Direktorat P2PTM.
20. Kementerian Kesehatan RI. (2022). Pedoman Pengelolaan Penyakit Ginjal Kronis di Fasilitas Kesehatan. Jakarta: Direktorat Pencegahan dan Pengendalian Penyakit Tidak Menular.
21. Khalil, A., Saeed, R., & Omar, H. (2021). Hemodialysis-induced metabolic changes and their clinical implications. Journal of Renal Care, 47(2), 125–134.
22. LeMone, P., Burke, K. M., Bauldoff, G., & Gubrud, P. (2016). Medical-surgical nursing: Clinical reasoning in patient care (6th ed.). Pearson.
23. Lestari, I., Pratiwi, J., & Hariyono, R. (2024). Pengaruh hemodialisis terhadap kadar glukosa darah pada pasien gagal ginjal kronik di UOBK RSUD Syarifah Ambami Rato Ebu Bangkalan (Skripsi). PPNI Bangkalan.
24. Mailloux, L., & Bell, R. (2021). Insulin resistance changes following hemodialysis therapy in chronic kidney disease patients. Journal of Nephrology and Metabolic Function, 12(3), 145–152.
25. Nasution, M., Pane, F., & Lubis, A. (2022). Hubungan hemodialisis terhadap perubahan kadar glukosa darah pada pasien gagal ginjal kronis. Jurnal Kesehatan Medis, 11(2), 85–92.
26. Nasution, R. (2021). Fluktuasi kadar glukosa darah sebelum dan sesudah hemodialisis. Jurnal Keperawatan Medikal Bedah, 11(2), 65–72.
27. National Kidney Foundation. (2020). KDOQI Clinical Practice Guideline for Diabetes and CKD: 2020 Update. American Journal of Kidney Diseases, 77(5), S1–S107.
28. Notoadmodjo, S. (2017). Metodologi Penelitian Kesehatan. Jakarta: Rineka Cipta.
29. Nursalam. (2020). Metodologi Penelitian Ilmu Keperawatan: Pendekatan Praktis (Edisi ke-5). Jakarta: Salemba Medika.
30. Perkumpulan Endokrinologi Indonesia. (2021). Konsensus pengelolaan dan pencegahan diabetes melitus tipe 2 di Indonesia. PERKENI.
31. Perreault, L., & Mather, K. (2021). Prediabetes: Pathophysiology and management. The Lancet Diabetes & Endocrinology, 9(9), 560–570.
32. Pratiwi, S. (2022). Perubahan kadar glukosa darah sebelum dan sesudah hemodialisis pada pasien gagal ginjal kronik. Jurnal Keperawatan Medikal Bedah, 10(2), 77–84.
33. Rahayu, S., & Siregar, D. (2023). Analisis kadar glukosa darah sebelum dan sesudah hemodialisis pada pasien penyakit ginjal kronis. Jurnal Keperawatan Indonesia, 26(1), 33–41.
34. Rahman, F., Widodo, S., & Hadi, A. (2022). Pengaruh penggunaan dialisat glukosa terhadap kadar glukosa darah pasien hemodialisis. Jurnal Nefrologi Indonesia, 8(1), 44–52.
35. Rhee, C. M., Gianchandani, R. Y., Kerr, D., Philis Tsimikas, A., Kovesdy, C. P., Stanton, R. C., Drincic, A. T., Galindo, R. J., Kalantar Zadeh, K., Neumiller, J. J., de Boer, I. H., Lind, M., Kim, S. H., Ayers, A. T., Ho, C. N., Aaron, R. E., Tian, T., Klonoff, D. C., & Diabetes Technology Society Expert Panel. (2024). Consensus report on the use of continuous glucose monitoring in chronic kidney disease and diabetes. Journal of Diabetes Science and Technology. Advance online publication.
36. Romero, A., Ortiz, R., & Vasquez, L. (2020). Impact of hemodialysis on glucose metabolism and glycemic fluctuations. Clinical Dialysis Review, 9(1), 54–62.
37. Ruppert, M., Thomas, G., & Lee, J. (2020). Insulin resistance and glycemic variability in chronic kidney disease patients undergoing hemodialysis. Nephrology Journal, 15(3), 201–209.
38. Saragih, D. (2022). Fluktuasi kadar glukosa darah pada pasien diabetes melitus yang menjalani hemodialisis. Jurnal Kesehatan Indonesia, 18(4), 89–97.
39. Sembiring, T., Irmawati, Sabir, M., & Tjahyadi, I. (2023). Buku Ajar Metodologi Penelitian (Teori dan Praktik). CV. Saba Jaya Publisher.
40. Shi, Y., Wang, T., Ding, Z., Yan, L., Yao, C., & Qian, H. (2025). Frequent hypoglycemia during hemodialysis in ESRD patients leads to higher risk of death. Renal Failure, 47(1), 2484471.
41. Siregar, L. (2022). Perubahan kadar glukosa darah pada pasien hemodialisis dengan diabetes mellitus. Jurnal Ilmiah Keperawatan Indonesia, 9(3), 120–129.
42. Tan, J., Li, M., Xu, Y., Chen, X., & Zhou, Y. (2021). Glycemic patterns and factors associated with post-hemodialysis hyperglycemia in diabetic patients: A continuous glucose monitoring study. Endocrine Journal, 68(3), 321–329.
43. Thomas, M. C. (2020). Insulin resistance and kidney disease. Clinical Journal of the American Society of Nephrology, 15(7), 1024–1032.
44. Wahyuni, D. (2021). Perubahan Kadar Gula Darah Sebelum dan Sesudah Hemodialisa pada Pasien Gagal Ginjal Kronik. Jurnal Keperawatan, 13(1), 25–31.
45. Wang, Y., Liu, Q., & Chen, H. (2019). Effects of glucose-containing dialysate on glycemic levels in dialysis patients. International Journal of Nephrology, 24(1), 55–63.
46. Zhang, Y., & Li, X. (2020). Glycemic variation and metabolic response in chronic kidney disease patients undergoing hemodialysis. Journal of Clinical Dialysis, 15(4), 211–219.
Published
2026-02-25
How to Cite
Nurhayti Abudi Ali, Nasrun Pakaya, & Gusti Pandi Liputo. (2026). The Effect of Hemodialysis Therapy on Blood Glucose Levels in Patients in the Hemodialysis Room Prof. Dr. H. Aloei Saboe General Hospital Gorontalo City. International Journal of Health, Economics, and Social Sciences (IJHESS), 8(2). https://doi.org/10.56338/ijhess.v8i2.10510
Section
Articles
Copyright (c) 2026 Nurhayti Abudi Ali, Nasrun Pakaya, Gusti Pandi Liputo
This work is licensed under a Creative Commons Attribution-ShareAlike 4.0 International License.
