Anti-Inflammatory Effect of Anthill Ointment Extract (Myrmecodia pendens) on White Rats
Abstract
Inflammation is the body's response to foreign substances that enter the body and is characterized by redness, fever, swelling, pain, and impaired organ function. Anti-inflammatory is a term for substances or medicines that work to reduce or suppress the inflammatory process. One of the plants originating from Papua is anthill (Myrmecodia pendens). Ant nest (Myrmecodia pendens) contains lots of synthetic secondary metabolite substances such as flavonoids, saponins, tannins, and alkaloids. That ingredient is presumed to have an effect as anti-inflammatory. This research aims to examine the anti-inflammatory effectiveness of anthill ointment extract (Myrmecodia pendens) on the feet of white rats induced by carrageenan. The test group was divided into 5 groups in which each group consisted of 3 rats. The positive control group was subjected to bioplacenton, the negative control to ointment base, and the extract group to anthill ointment extract (Myrmecodia pendens) with concentrations of F1 (10%), F2 (20%), and F3 (40%). The test was conducted by inserting 1% carrageenan liquid into the sole of the rat's right paw. The volume of edema was measured using a syrup bottle filled with water every 60 minutes for 360 minutes. The data were analyzed statistically using (ANOVA) and obtained data p = 0.580 > 0.05. The conclusion of this research is that there is no significant difference in the percent of anti-inflammatory power between the dose groups F1 (10%), F2 (20%) and F3 (40%) with positive control.
References
Astuti LA, Anas R, Hasanuddin NR, Pamewa K, Chotimah C, Ridha DAP. Efektivitas Ekstrak Etanol Tanaman Sarang Semut Terhadap Daya Hambat Bakteri Fusobacterium nucleatum (In Vitro). Sinnun Maxillofac J. 2021;2(01):8–17.
Yuliani W, Ismail R. Uji Aktivitas Antijamur Fungi Endofit Tanaman Sarang Semut (Myrmecodia pendans) Terhadap Jamur Candida albicans. Pharm Genius. 2023;2(1):31–42.
Yuliandri R, Martati E, Wardani AK. Ekstraksi Sarang Ssemut (Myrmecodia Pendans) Dengan Microwave-Assisted Extraction dan Aplikasinya sebagai Antibakteri pada Ikan Kakap Merah Microwave-Assisted Extraction of Ant-Nest (Myrmecodia Pendans) and its Application as Antibacterial Agents on Red S. J Teknol Pertan. 2019;20(3):193–202.
Santi I, Putra B, Wahyuni S. Uji Efek Ekstrak Etanol Daun Cincau Hijau (Cyclea barbata Miers) sebagai Antiinflamasi pada Tikus Putih yang Diinduksi Karagen. J Ilm As-Syifaa. 2017;9(1):58–66.
Setyopuspito Pramitaningastuti A. Uji Efektivitas Antiinflamasi Ekstrak Etanol Daun Srikaya (Annona Squamosa. L) Terhadap Edema Kaki Tikus Putih Jantan Galur Wistar. J Ilm Farm. 2017;13(1):8–14.
Octavian IPY. Uji Aktivitas Antiinflamasi Ekstrak Etanol Tanaman Patah Tulang (Euphorbia tirucalli L.). J MIPA. 2020;9(2):60.
Ni Made Sugi Pradnyasuari, Anak Agung Gede Rai Yadnya Putra. Potensi Tanaman Jeruju (Acanthus ilicifolius L.) sebagai Antiinflamasi. Pros Work dan Semin Nas Farm. 2023;2:218–30.
Mukhriani, Nurshalati Tahar, Muhammad Rusdi K, Almaidah MF. Uji Aktivitas Anti Inflamasi Ekstrak Etanol Daun Buni (Antidesma Bunius L. Spreng) Terhadap Tikus Putih (Rattus Norvegicus). Pakistan Res J Manag Sci. 2018;7(5):1–2.
Isrul M, Dewi C, Wahdini V. Uji Efek Antiinflamasi Infusa Daun Bayam Merah (Amaranthus tricolor L.) Terhadap Tikus Putih (Rattus norvegicus) Yang Diinduksi Karagenan. J Mandala Pharmacon Indones. 2020;6(2):97–103.
Sudirman RS, Usmar U, Rahim A, Bahar MA. Aktivitas Anti-inflamasi Ekstrak Etanol Daun Beluntas (Pluchea indica L.) pada Model Inflamasi Terinduksi CFA (Complete Freund’s Adjuvant). J Farm Galen (Galenika J Pharmacy). 2017;3(2):191–8.
Emelda E, Nugraeni R, Damayanti K. Review: Exploration of Indonesian Herbal Plants for Anti Inflammatory. INPHARNMED J (Indonesian Pharm Nat Med Journal). 2023;6(2):58.
Astika RY, Sani K F, Elisma. Uji Aktivitas Antiinflamasi Ekstrak Etanol Daun Kayu Manis (Cinnamomum burmanni) pada Mencit Putih Jantan. J Ilm Manuntung. 2022;8(1):14–23.
Nurjanah F, Sumiwi SA. Review Artikel: aktivitas antiinflamasi berbagai tumbuhan yang diinduksi oleh karagenan. J Unpad. 2020;17(1):135–46.
Cendana Y, Adrianta KA, Suena NMDS. Formulasi Spray Gel Minyak Atsiri Kayu Cendana (Santalum album L.). J Ilm Medicam. 2021;7(2):84–9.
Wenny Siswanty P, Agus Wibowo M, Harlia. Aktivitas Toksisitas Antioksidan dan Antiinflamasi Secara In Vitro dari Ekstrak Metanol Daun Mangga Bacang (Mangifera foetida L). J Kim Khatulistiwa. 2017;6(1):42–9.
Pattiwael M, Wattimena L, Klagilit Y. Pemanfaatan Tumbuhan Sarang Semut (Myrmecodia pendens) Sebagai Obat Tradisional Oleh Masyarakat Kampung Wailen Distrik Salawati Tengah Kabupaten Raja Ampat. Median J Ilmu Ilmu Eksakta. 2022;13(3):131–7.
Anggitasari W, Pebriarti IW, Rindiantika BK. Uji Aktivitas Antiinflamasi Salep Ekstrak Daun Cengkeh ( Syzygium aromaticum ). J Mandala Pharmacon Indones. 2023;9(2):596–603.
Triswanto Sentat 1 FH 1. UJI EFEK ANTIINFLAMASI EKSTRAK ETANOL BIJI LAMTORO (Leucaena leucocephala L.). J ILMU Kesehat. 2018;6(1):84–9.
Rio Rifaldy M, Yuniarni U, Farmasi P, Matematika dan Ilmu Pengetahuan Alam F. Uji Aktivitas Ekstrak Etanol Daun Mengkudu (Morinda Citrifolia L) sebagai Antiinflamasi terhadap Tikus Wistar Jantan Evaluation of Noni Leaves Ethanol Extract (Morinda citrifolia L) Activities as Anti-Inflamation on The Wistar Male Rats. Posiding Farm. 2019;5(2).
Kamal A, Tibe F, Anggi V. UJI ANTIINFLAMASI EKSTRAK ETANOL KULIT BATANG CEREMAI (Phyllanthus acidus L.Skell) TERHADAP EDEMA KAKI TIKUS. J Farm. 2018;XV(1):1–8.
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