Anemia Defisiensi Besi Pada Obesitas : Literature Review
Keywords:
anemia, obesity, review
Abstract
Secara global.terjadi peningkatan kejadian obesitas. Obesitas sendiri merupakan permasalahan gizi yang berdampak terhadap permasalahan kesehatan lainnya. Selain berdampak terhadap penyakit metabolik, obesitas juga disinyalir menginisiasi adanya gangguan kekurangan mikronutrien yaitu anemia defisiensi besi. Artikel ini bertujuan untuk mengetahui lebih lanjut hubungan antara obesitas dengan kejadian anemia defisiensi besi. Studi review ini menggunakan database PubMed Central, ScienceDirect dan Taylor&Francis menggunakan kata kunci “obesity” or “anemia”, “anemia in obesity”. Didapatkan hasil bahwa individu yang obesitas erat dikaitkan dengan kejadian anemia beserta penanda anemia seperti serum besi, MCV, transferrin dan ferritin.
References
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Alshwaiyat, N. M., Ahmad, A., Wan Hassan, W. M. R., & Al-Jamal, H. A. N. (2021). Association between obesity and iron deficiency (Review). Experimental and therapeutic medicine, 22(5), 1268. https://doi.org/10.3892/etm.2021.10703Cepeda-Lopez, A.C., Zimmermann, M.B., Wussler, S. et al. Greater blood volume and Hb mass in obese women quantified by the carbon monoxide-rebreathing method affects interpretation of iron biomarkers and iron requirements. Int J Obes 43, 999–1008 (2019). https://doi.org/10.1038/s41366-018-0127-9
Collins, J. F., Wessling-Resnick, M., & Knutson, M. D. (2008). Hepcidin regulation of iron transport. The Journal of nutrition, 138(11), 2284–2288. https://doi.org/10.3945/jn.108.096347
Fruh SM. Obesity: Risk factors, complications, and strategies for sustainable long-term weight management. J Am Assoc Nurse Pract. 2017 Oct;29(S1):S3-S14. doi: 10.1002/2327-6924.12510. PMID: 29024553; PMCID: PMC6088226
Gurevich-Panigrahi T, Panigrahi S, Wiechec E, Los M. Obesity: pathophysiology and clinical management. Curr Med Chem. 2009;16(4):506-21. doi: 10.2174/092986709787315568. PMID: 19199918.
Hill JO, Wyatt HR, Peters JC. Energy balance and obesity. Circulation. 2012 Jul 3;126(1):126-32. doi: 10.1161/CIRCULATIONAHA.111.087213. PMID: 22753534; PMCID: PMC3401553.
Jeong, J., Cho, Y., Cho, I. Y., & Ahn, J. (2022). Association between Obesity and Anemia in a Nationally Representative Sample of South Korean Adolescents: A Cross-Sectional Study. Healthcare (Basel, Switzerland), 10(6), 1055. https://doi.org/10.3390/healthcare10061055
Johnson, Richard & Sánchez-Lozada, Laura & Andrews, Peter & Lanaspa, Miguel. (2017). Perspective: A Historical and Scientific Perspective of Sugar and Its Relation with Obesity and Diabetes. Advances in Nutrition: An International Review Journal. 8. 412-422. 10.3945/an.116.014654.
Jordaana, E. M., V. L. Van den Berga, F. C. Van Rooyen, and C. M. Walsh. 2020. Obesity is associated with anaemia and iron deficiency indicators among women in the rural Free State, South Africa. South African Journal of Clinical Nutrition 33 (3):72–78. doi:https://doi.org/10.1080/16070658.2018.1553361.
Kern, L., Mittenbühler, M. J., Vesting, A. J., Ostermann, A. L., Wunderlich, C. M., & Wunderlich, F. T. (2018). Obesity-Induced TNF? and IL-6 Signaling: The Missing Link between Obesity and Inflammation-Driven Liver and Colorectal Cancers. Cancers, 11(1), 24. https://doi.org/10.3390/cancers11010024
Khemphet, R., & Yupensuk, N. (2022). Prevalence and association between obesity and iron deficiency in children. Journal of the Medical Association of Thailand, 105(3), 212–218. https://doi.org/10.35755/jmedassocthai.2022.03.13279
Kirthan, J. P. A., & Somannavar, M. S. (2023). Pathophysiology and management of iron deficiency anaemia in pregnancy: a review. Annals of hematology, 10.1007/s00277-023-05481-2. Advance online publication. https://doi.org/10.1007/s00277-023-05481-2
Cepeda-Lopez, A. C., Zimmermann, M. B., Wussler, S., Melse-Boonstra, A., Naef, N., Mueller, S. M., Toigo, M., & Herter-Aeberli, I. (2019). Greater blood volume and Hb mass in obese women quantified by the carbon monoxide-rebreathing method affects interpretation of iron biomarkers and iron requirements. International journal of obesity (2005), 43(5), 999–1008. https://doi.org/10.1038/s41366-018-0127-9
Mahmoud, Ibrahim, El, Nashar., Rasha, Mohamed, Gamal, EL-Shafiey., Mohammed, Attia, Saad., Mohammed, Amr, Hamam. (2021). Serum Hepcidin Level in Obese Children and Adolescents: It’s Association with Iron Deficiency Anemia. Journal of Advances in Medicine and Medical Research, 77-88. doi: 10.9734/JAMMR/2021/V33I430836
Manios, Y., Moschonis, G., Chrousos, G. P., Lionis, C., Mougios, V., Kantilafti, M., Tzotzola, V., Skenderi, K. P., Petridou, A., Tsalis, G., Sakellaropoulou, A., Skouli, G., & Katsarou, C. (2013). The double burden of obesity and iron deficiency on children and adolescents in Greece: the Healthy Growth Study. Journal of human nutrition and dietetics : the official journal of the British Dietetic Association, 26(5), 470–478. https://doi.org/10.1111/jhn.12025
Mehdad, Slimane & Benaich, Souad & Hamdouchi, Asmaa & Bouhaddou, Nezha & Azlaf, Mehdi & el, Imane & Belghiti, H. & Benkirane, Hasnae & Lahmame, Houria & Barkat, Amina & Khalid, EL KARI & El Mzibri, Mohammed & Aguenaou, Hassan. (2022). Association between overweight and anemia in Moroccan adolescents: a cross-sectional study. Pan African Medical Journal. 41. 10.11604/pamj.2022.41.156.20927.
Muh., Nur, Hasan, Syah. (2022). The Relationship between Obesity and Anemia among Adolescent Girls. Poltekita: Jurnal Ilmu Kesehatan, 15(4):355-359. doi: 10.33860/jik.v15i4.712
Pagani, A., Nai, A., Silvestri, L., & Camaschella, C. (2019). Hepcidin and Anemia: A Tight Relationship. Frontiers in physiology, 10, 1294. https://doi.org/10.3389/fphys.2019.01294
Purdy, J. C., & Shatzel, J. J. (2021). The hematologic consequences of obesity. European journal of haematology, 106(3), 306–319. https://doi.org/10.1111/ejh.13560
Rah JH, Melse-Boonstra A, Agustina R, van Zutphen KG, Kraemer K. The Triple Burden of Malnutrition Among Adolescents in Indonesia. Food and Nutrition Bulletin. 2021;42(1_suppl):S4-S8. doi:10.1177/03795721211007114
Rodríguez-Mortera, R., Caccavello, R., Hermo, R., Garay-Sevilla, M. E., & Gugliucci, A. (2021). Higher Hepcidin Levels in Adolescents with Obesity Are Associated with Metabolic Syndrome Dyslipidemia and Visceral Fat. Antioxidants (Basel, Switzerland), 10(5), 751. https://doi.org/10.3390/antiox10050751
Sanad, M., Osman, M., & Gharib, A. (2011). Obesity modulate serum hepcidin and treatment outcome of iron deficiency anemia in children: a case control study. Italian journal of pediatrics, 37, 34. https://doi.org/10.1186/1824-7288-37-34
Seifu, C. N., Fahey, P. P., & Atlantis, E. (2022). Micronutrient deficiencies and anaemia associated with body mass index in Australian adults: a cross-sectional study. BMJ open, 12(12), e061442. https://doi.org/10.1136/bmjopen-2022-061442
Sixtus, Aguree., Arthur, H., Owora., Misty, A.W., Hawkins., Manju, B., Reddy. (2023). Iron Deficiency and Iron Deficiency Anemia in Women with and without Obesity: NHANES 2001–2006. Nutrients, 15(10):2272-2272. doi: 10.3390/nu15102272
Stankowiak-Kulpa, H., Kargulewicz, A., Styszy?ski, A., Swora-Cwynar, E., & Grzymis?awski, M. (2017). Iron status in obese women. Annals of agricultural and environmental medicine : AAEM, 24(4), 587–591. https://doi.org/10.5604/12321966.1232092
Suega, K., & Widiana, G. R. (2019). Predicting hepcidin level using inflammation markers and iron indicators in patients with anemia of chronic disease. Hematology, transfusion and cell therapy, 41(4), 342–348. https://doi.org/10.1016/j.htct.2019.03.011
Tiwari A, Balasundaram P. Public Health Considerations Regarding Obesity. [Updated 2022 Sep 3]. In: StatPearls [Internet]. Treasure Island (FL): StatPearls Publishing; 2022 Jan-. Available from: https://www.ncbi.nlm.nih.gov/books/NBK572122/
Tingting, Wang., Qiyue, Gao., Yuanyuan, Yao., Mingxia, Liu., Xuejie, Li., Dawei, Sun., Zhenzhen, Cheng., Chaomin, Wu., Ruiyu, Wang., Jingcheng, Zou., Mi, Yan. (2023). Causal relationship between obesity and iron deficiency anemia: a two-sample Mendelian randomization study. Frontiers in Public Health, 11 doi: 10.3389/fpubh.2023.1188246
V., M., Nedoborenko., I., P., Kaidashev. (2019). The impact of obesity on the course of iron deficiency anemia in women and assessment of their quality of life. 22-28. doi: 10.31640/JVD.4.2019(4)
World Health Organization. (?2000)?. The Asia-Pacific Perspective : Redefining Obesity and its treatment. World Health Organization. https:// apps.who.int/iris/bitstream/handle/10665/206936/0957708211
Alshwaiyat, N. M., Ahmad, A., Wan Hassan, W. M. R., & Al-Jamal, H. A. N. (2021). Association between obesity and iron deficiency (Review). Experimental and therapeutic medicine, 22(5), 1268. https://doi.org/10.3892/etm.2021.10703Cepeda-Lopez, A.C., Zimmermann, M.B., Wussler, S. et al. Greater blood volume and Hb mass in obese women quantified by the carbon monoxide-rebreathing method affects interpretation of iron biomarkers and iron requirements. Int J Obes 43, 999–1008 (2019). https://doi.org/10.1038/s41366-018-0127-9
Collins, J. F., Wessling-Resnick, M., & Knutson, M. D. (2008). Hepcidin regulation of iron transport. The Journal of nutrition, 138(11), 2284–2288. https://doi.org/10.3945/jn.108.096347
Fruh SM. Obesity: Risk factors, complications, and strategies for sustainable long-term weight management. J Am Assoc Nurse Pract. 2017 Oct;29(S1):S3-S14. doi: 10.1002/2327-6924.12510. PMID: 29024553; PMCID: PMC6088226
Gurevich-Panigrahi T, Panigrahi S, Wiechec E, Los M. Obesity: pathophysiology and clinical management. Curr Med Chem. 2009;16(4):506-21. doi: 10.2174/092986709787315568. PMID: 19199918.
Hill JO, Wyatt HR, Peters JC. Energy balance and obesity. Circulation. 2012 Jul 3;126(1):126-32. doi: 10.1161/CIRCULATIONAHA.111.087213. PMID: 22753534; PMCID: PMC3401553.
Jeong, J., Cho, Y., Cho, I. Y., & Ahn, J. (2022). Association between Obesity and Anemia in a Nationally Representative Sample of South Korean Adolescents: A Cross-Sectional Study. Healthcare (Basel, Switzerland), 10(6), 1055. https://doi.org/10.3390/healthcare10061055
Johnson, Richard & Sánchez-Lozada, Laura & Andrews, Peter & Lanaspa, Miguel. (2017). Perspective: A Historical and Scientific Perspective of Sugar and Its Relation with Obesity and Diabetes. Advances in Nutrition: An International Review Journal. 8. 412-422. 10.3945/an.116.014654.
Jordaana, E. M., V. L. Van den Berga, F. C. Van Rooyen, and C. M. Walsh. 2020. Obesity is associated with anaemia and iron deficiency indicators among women in the rural Free State, South Africa. South African Journal of Clinical Nutrition 33 (3):72–78. doi:https://doi.org/10.1080/16070658.2018.1553361.
Kern, L., Mittenbühler, M. J., Vesting, A. J., Ostermann, A. L., Wunderlich, C. M., & Wunderlich, F. T. (2018). Obesity-Induced TNF? and IL-6 Signaling: The Missing Link between Obesity and Inflammation-Driven Liver and Colorectal Cancers. Cancers, 11(1), 24. https://doi.org/10.3390/cancers11010024
Khemphet, R., & Yupensuk, N. (2022). Prevalence and association between obesity and iron deficiency in children. Journal of the Medical Association of Thailand, 105(3), 212–218. https://doi.org/10.35755/jmedassocthai.2022.03.13279
Kirthan, J. P. A., & Somannavar, M. S. (2023). Pathophysiology and management of iron deficiency anaemia in pregnancy: a review. Annals of hematology, 10.1007/s00277-023-05481-2. Advance online publication. https://doi.org/10.1007/s00277-023-05481-2
Cepeda-Lopez, A. C., Zimmermann, M. B., Wussler, S., Melse-Boonstra, A., Naef, N., Mueller, S. M., Toigo, M., & Herter-Aeberli, I. (2019). Greater blood volume and Hb mass in obese women quantified by the carbon monoxide-rebreathing method affects interpretation of iron biomarkers and iron requirements. International journal of obesity (2005), 43(5), 999–1008. https://doi.org/10.1038/s41366-018-0127-9
Mahmoud, Ibrahim, El, Nashar., Rasha, Mohamed, Gamal, EL-Shafiey., Mohammed, Attia, Saad., Mohammed, Amr, Hamam. (2021). Serum Hepcidin Level in Obese Children and Adolescents: It’s Association with Iron Deficiency Anemia. Journal of Advances in Medicine and Medical Research, 77-88. doi: 10.9734/JAMMR/2021/V33I430836
Manios, Y., Moschonis, G., Chrousos, G. P., Lionis, C., Mougios, V., Kantilafti, M., Tzotzola, V., Skenderi, K. P., Petridou, A., Tsalis, G., Sakellaropoulou, A., Skouli, G., & Katsarou, C. (2013). The double burden of obesity and iron deficiency on children and adolescents in Greece: the Healthy Growth Study. Journal of human nutrition and dietetics : the official journal of the British Dietetic Association, 26(5), 470–478. https://doi.org/10.1111/jhn.12025
Mehdad, Slimane & Benaich, Souad & Hamdouchi, Asmaa & Bouhaddou, Nezha & Azlaf, Mehdi & el, Imane & Belghiti, H. & Benkirane, Hasnae & Lahmame, Houria & Barkat, Amina & Khalid, EL KARI & El Mzibri, Mohammed & Aguenaou, Hassan. (2022). Association between overweight and anemia in Moroccan adolescents: a cross-sectional study. Pan African Medical Journal. 41. 10.11604/pamj.2022.41.156.20927.
Muh., Nur, Hasan, Syah. (2022). The Relationship between Obesity and Anemia among Adolescent Girls. Poltekita: Jurnal Ilmu Kesehatan, 15(4):355-359. doi: 10.33860/jik.v15i4.712
Pagani, A., Nai, A., Silvestri, L., & Camaschella, C. (2019). Hepcidin and Anemia: A Tight Relationship. Frontiers in physiology, 10, 1294. https://doi.org/10.3389/fphys.2019.01294
Purdy, J. C., & Shatzel, J. J. (2021). The hematologic consequences of obesity. European journal of haematology, 106(3), 306–319. https://doi.org/10.1111/ejh.13560
Rah JH, Melse-Boonstra A, Agustina R, van Zutphen KG, Kraemer K. The Triple Burden of Malnutrition Among Adolescents in Indonesia. Food and Nutrition Bulletin. 2021;42(1_suppl):S4-S8. doi:10.1177/03795721211007114
Rodríguez-Mortera, R., Caccavello, R., Hermo, R., Garay-Sevilla, M. E., & Gugliucci, A. (2021). Higher Hepcidin Levels in Adolescents with Obesity Are Associated with Metabolic Syndrome Dyslipidemia and Visceral Fat. Antioxidants (Basel, Switzerland), 10(5), 751. https://doi.org/10.3390/antiox10050751
Sanad, M., Osman, M., & Gharib, A. (2011). Obesity modulate serum hepcidin and treatment outcome of iron deficiency anemia in children: a case control study. Italian journal of pediatrics, 37, 34. https://doi.org/10.1186/1824-7288-37-34
Seifu, C. N., Fahey, P. P., & Atlantis, E. (2022). Micronutrient deficiencies and anaemia associated with body mass index in Australian adults: a cross-sectional study. BMJ open, 12(12), e061442. https://doi.org/10.1136/bmjopen-2022-061442
Sixtus, Aguree., Arthur, H., Owora., Misty, A.W., Hawkins., Manju, B., Reddy. (2023). Iron Deficiency and Iron Deficiency Anemia in Women with and without Obesity: NHANES 2001–2006. Nutrients, 15(10):2272-2272. doi: 10.3390/nu15102272
Stankowiak-Kulpa, H., Kargulewicz, A., Styszy?ski, A., Swora-Cwynar, E., & Grzymis?awski, M. (2017). Iron status in obese women. Annals of agricultural and environmental medicine : AAEM, 24(4), 587–591. https://doi.org/10.5604/12321966.1232092
Suega, K., & Widiana, G. R. (2019). Predicting hepcidin level using inflammation markers and iron indicators in patients with anemia of chronic disease. Hematology, transfusion and cell therapy, 41(4), 342–348. https://doi.org/10.1016/j.htct.2019.03.011
Tiwari A, Balasundaram P. Public Health Considerations Regarding Obesity. [Updated 2022 Sep 3]. In: StatPearls [Internet]. Treasure Island (FL): StatPearls Publishing; 2022 Jan-. Available from: https://www.ncbi.nlm.nih.gov/books/NBK572122/
Tingting, Wang., Qiyue, Gao., Yuanyuan, Yao., Mingxia, Liu., Xuejie, Li., Dawei, Sun., Zhenzhen, Cheng., Chaomin, Wu., Ruiyu, Wang., Jingcheng, Zou., Mi, Yan. (2023). Causal relationship between obesity and iron deficiency anemia: a two-sample Mendelian randomization study. Frontiers in Public Health, 11 doi: 10.3389/fpubh.2023.1188246
V., M., Nedoborenko., I., P., Kaidashev. (2019). The impact of obesity on the course of iron deficiency anemia in women and assessment of their quality of life. 22-28. doi: 10.31640/JVD.4.2019(4)
World Health Organization. (?2000)?. The Asia-Pacific Perspective : Redefining Obesity and its treatment. World Health Organization. https:// apps.who.int/iris/bitstream/handle/10665/206936/0957708211
Published
2024-06-05
Section
Artikel Review
