Pengaruh Levothyroxin terhadap kadar TSH pada Lansia yang Menderita Hipotiroid – Tinjauan Sistematis
Effect of Levothyroxine on TSH Levels in Elderly Patients with Hypothyroidism – Systematic Review
Keywords:
Hipotiroid, Levotiroksin, Lansia
Abstract
Levotiroksin (L-tiroksin, Lt4) merupakan obat yang umum diresepkan pada penderita hipotiroid terutama pasien yang berusia lanjut (lansia). Tinjauan ini bertujuan untuk merangkum bukti pengaruh LT4 terhadap kadar TSH, baik yang menggunakan dosis biasa atau pun yang menggunakan modifikasi dosis LT4 untuk mencapai kadar TSH yang ditargetkan. Sebanyak 138 artikel diidentifikasi melalui pencarian literatur sistematis. Setelah disaring, tersisa 6 artikel yang dimasukkan dalam sintesis kualitatif.
References
1. Effraimidis, Grigoris. , Torquil Watt and Ulla Feldt-Rasmussen. 2021. Levothyroxine Therapy in Elderly Patients With Hypothyroidism. Endocrinology : 12
2. Kemenkes, R. (2017). Analisis Lansia di Indonesia. Jakarta: Kemenkes RI.
3. Calsolaro,. Valeria et al. 2019. Hypothyroidism in the Elderly: Who Should Be Treated and How?. Journal of the Endocrine Society : 03 (01)
4. Calissendorff .,Jan and Henrik Falhammar. 2020. To Treat or Not to Treat Subclinical Hypothyroidism, What Is the Evidence?, Medicina : 56 (40)
5. Manaf, Asman dkk. 2018. Improving Health Care Provider’s Competencies In Internal Medicine In Jkn Era. Bagian Ilmu Penyakit Dalam Fakultas Kedokteran Andalas : Padang
6. Kusumadewi, Made Savitra., kadek Susila Surya Darma dan Wayan Aryadana. 2020. Prevalensi Fibrilasi Atrium pada Pasien Hipotiroidisme Di Poliklinik Endokrin RSUP Sanglah. Jurnal Medika Udayana : 09 (07)
7. Ross,. Douglas S. 2022. Treating hypothyroidism is not always easy: When to treat subclinical hypothyroidism, TSH goals in the elderly, and alternatives to levothyroxine monotherapy. Journal International Mecdical : 291(128–140)
8. Azim.,Sidra, And Christian Nasr. 2019. Subclinical hypothyroidism: When to treat. Cleveland Clinic Journal Of Medicine : 86
9. Javed., Zeeshan and Thozhukat Sathyapalan. 2016. Levothyroxine treatment of mild subclinical hypothyroidism: a review of potential risks and benefits. Vol. 7(1) 12–23
10. De Montmollin M, Feller M, Beglinger S, McConnachie A, Aujesky D, Collet TH, et al. L-thyroxine therapy for older adults with subclinical hypothyroidism and hypothyroid symptoms: Secondary analysis of a randomized trial. Ann Intern Med. 2020;172(11):709–16.
11. Wilkes S, Pearce S, Ryan V, Rapley T, Ingoe L, Razvi S. Study of Optimal Replacement of Thyroxine in the ElDerly (SORTED): Protocol for a mixed methods feasibility study to assess the clinical utility of lower dose thyroxine in elderly hypothyroid patients: Study protocol for a randomized controlled trial. Trials. 2013;14(1):1–12.
12. Razvi S, Ingoe L, Ryan V, Pearce SHS, Wilkes S. Study of Optimal Replacement of Thyroxine in the Elderly (SORTED) - results from the feasibility randomised controlled trial. Thyroid Res. 2016;9(1):1–9.
13. Du Puy RS, Postmus I, Stott DJ, Blum MR, Poortvliet RKE, Den Elzen WPJ, et al. Study protocol: A randomised controlled trial on the clinical effects of levothyroxine treatment for subclinical hypothyroidism in people aged 80 years and over 11 Medical and Health Sciences 1117 Public Health and Health Services 11 Medical and Health Sc. BMC Endocr Disord. 2018;18(1):1–14.
14. Stott et al. Thyroid Hormone Therapy for Older Adults with Subclinical Hypothyroidism. 2017;13(562):1024.
15. Fuhrer D, Nitschmann S. Therapie der latenten Hypothyreose bei Alteren: Thyroid Hormone Replacement for Untreated Older Adults with Subclinical Hypothyroidism (TRUST). Internist. 2018;59(3):304–6.
2. Kemenkes, R. (2017). Analisis Lansia di Indonesia. Jakarta: Kemenkes RI.
3. Calsolaro,. Valeria et al. 2019. Hypothyroidism in the Elderly: Who Should Be Treated and How?. Journal of the Endocrine Society : 03 (01)
4. Calissendorff .,Jan and Henrik Falhammar. 2020. To Treat or Not to Treat Subclinical Hypothyroidism, What Is the Evidence?, Medicina : 56 (40)
5. Manaf, Asman dkk. 2018. Improving Health Care Provider’s Competencies In Internal Medicine In Jkn Era. Bagian Ilmu Penyakit Dalam Fakultas Kedokteran Andalas : Padang
6. Kusumadewi, Made Savitra., kadek Susila Surya Darma dan Wayan Aryadana. 2020. Prevalensi Fibrilasi Atrium pada Pasien Hipotiroidisme Di Poliklinik Endokrin RSUP Sanglah. Jurnal Medika Udayana : 09 (07)
7. Ross,. Douglas S. 2022. Treating hypothyroidism is not always easy: When to treat subclinical hypothyroidism, TSH goals in the elderly, and alternatives to levothyroxine monotherapy. Journal International Mecdical : 291(128–140)
8. Azim.,Sidra, And Christian Nasr. 2019. Subclinical hypothyroidism: When to treat. Cleveland Clinic Journal Of Medicine : 86
9. Javed., Zeeshan and Thozhukat Sathyapalan. 2016. Levothyroxine treatment of mild subclinical hypothyroidism: a review of potential risks and benefits. Vol. 7(1) 12–23
10. De Montmollin M, Feller M, Beglinger S, McConnachie A, Aujesky D, Collet TH, et al. L-thyroxine therapy for older adults with subclinical hypothyroidism and hypothyroid symptoms: Secondary analysis of a randomized trial. Ann Intern Med. 2020;172(11):709–16.
11. Wilkes S, Pearce S, Ryan V, Rapley T, Ingoe L, Razvi S. Study of Optimal Replacement of Thyroxine in the ElDerly (SORTED): Protocol for a mixed methods feasibility study to assess the clinical utility of lower dose thyroxine in elderly hypothyroid patients: Study protocol for a randomized controlled trial. Trials. 2013;14(1):1–12.
12. Razvi S, Ingoe L, Ryan V, Pearce SHS, Wilkes S. Study of Optimal Replacement of Thyroxine in the Elderly (SORTED) - results from the feasibility randomised controlled trial. Thyroid Res. 2016;9(1):1–9.
13. Du Puy RS, Postmus I, Stott DJ, Blum MR, Poortvliet RKE, Den Elzen WPJ, et al. Study protocol: A randomised controlled trial on the clinical effects of levothyroxine treatment for subclinical hypothyroidism in people aged 80 years and over 11 Medical and Health Sciences 1117 Public Health and Health Services 11 Medical and Health Sc. BMC Endocr Disord. 2018;18(1):1–14.
14. Stott et al. Thyroid Hormone Therapy for Older Adults with Subclinical Hypothyroidism. 2017;13(562):1024.
15. Fuhrer D, Nitschmann S. Therapie der latenten Hypothyreose bei Alteren: Thyroid Hormone Replacement for Untreated Older Adults with Subclinical Hypothyroidism (TRUST). Internist. 2018;59(3):304–6.
