Potensi Fitokimia Bunga Telang (Clitoria ternatea L.) sebagai Kandidat Terapi SARS-Cov-2: Tinjauan Literatur
Phytochemical Potential of Clitoria ternatea L. as a Therapeutic Candidate Against SARS-CoV-2: A Literature Review
Keywords:
SARS-CoV-2; Clitoria ternatea; Bunga telang;
Abstract
Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) merupakan virus korona yang menyebabkan sindrom pernapasan akut berat yang dikenal sebagai Coronavirus Disease 2019 (COVID-19). Salah satu alternatif yang dapat dimanfaatkan masyarakat dalam menjaga kesehatan dan mendukung penanganan penyakit adalah penggunaan obat herbal. Artikel tinjauan ini bertujuan untuk mengkaji berbagai jenis obat herbal yang tersedia di Indonesia, manfaat Clitoria ternatea L. (bunga telang), serta aktivitas biologis senyawa-senyawa yang terkandung di dalamnya. Metode yang digunakan adalah studi literatur dengan mengumpulkan, menganalisis, dan mensintesis berbagai hasil penelitian yang relevan. Hasil kajian menunjukkan bahwa Clitoria ternatea L. mengandung berbagai senyawa bioaktif, antara lain antosianin, ternatin, taraxerol, genistein, steroid, asam fenolat, polifenol, senyawa fenolik, dan flavonoid. Senyawa-senyawa tersebut diketahui memiliki aktivitas antiinflamasi dan berpotensi membantu mengatasi proses inflamasi yang berhubungan dengan infeksi COVID-19. Oleh karena itu, Clitoria ternatea L. berpotensi dikembangkan sebagai kandidat terapi pendukung dalam penanganan SARS-CoV-2.
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Bogdan, R., & Taylor, S. J. (1975). Introduction to Qualitative Research Methods: A Phenomenological Approach to the Social Sciences. Wiley.
Chan, J. F.-W., Kok, K.-H., Zhu, Z., Chu, H., To, K. K.-W., Yuan, S., & Yuen, K.-Y. (2020). Genomic characterization of the 2019 novel human-pathogenic coronavirus isolated from a patient with atypical pneumonia after visiting Wuhan. Emerging Microbes & Infections, 9(1), 221–236. https://doi.org/10.1080/22221751.2020.1719902
Eastin, C., & Eastin, T. (2020). Clinical Characteristics of Coronavirus Disease 2019 in China. The Journal of Emergency Medicine, 58(4), 711–712. https://doi.org/10.1016/j.jemermed.2020.04.004
Guzik, T. J., Mohiddin, S. A., Dimarco, A., Patel, V., Savvatis, K., Marelli-Berg, F. M., Madhur, M. S., Tomaszewski, M., Maffia, P., D’Acquisto, F., Nicklin, S. A., Marian, A. J., Nosalski, R., Murray, E. C., Guzik, B., Berry, C., Touyz, R. M., Kreutz, R., Wang, D. W., … McInnes, I. B. (2020). COVID-19 and the cardiovascular system: Implications for risk assessment, diagnosis, and treatment options. Cardiovascular Research, 116(10), 1666–1687. https://doi.org/10.1093/cvr/cvaa106
Jaafar, N. F., Ramli, M. E., & Mohd Salleh, R. (2020). Optimum Extraction Condition of Clitorea ternatea Flower on Antioxidant Activities, Total Phenolic, Total Flavonoid and Total Anthocyanin Contents. Tropical Life Sciences Research, 31(2), 1–17. https://doi.org/10.21315/tlsr2020.31.2.1
Maity, N., Nema, N. K., Sarkar, B. K., & Mukherjee, P. K. (2012). Standardized Clitoria ternatea leaf extract as hyaluronidase, elastase and matrix-metalloproteinase-1 inhibitor. Indian Journal of Pharmacology, 44(5), 584–587. https://doi.org/10.4103/0253-7613.100381
Nugraha, A. P., Rahmadhani, D., Puspitaningrum, M. S., Rizqianti, Y., Kharisma, V. D., & Ernawati, D. S. (2021). Molecular docking of anthocyanins and ternatin in Clitoria ternatea as coronavirus disease oral manifestation therapy. Journal of Advanced Pharmaceutical Technology & Research, 12(4), 362–367. https://doi.org/10.4103/japtr.japtr_126_21
Pandey, P., Basnet, A., & Mali, A. (2020). Quest for COVID-19 cure: Integrating traditional herbal medicines in the modern drug paradigm. Applied Science and Technology Annals, 1(1), 63–71. (Nepal). https://doi.org/10.3126/asta.v1i1.30275
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Rothe, C., Schunk, M., Sothmann, P., Bretzel, G., Froeschl, G., Wallrauch, C., Zimmer, T., Thiel, V., Janke, C., Guggemos, W., Seilmaier, M., Drosten, C., Vollmar, P., Zwirglmaier, K., Zange, S., Wölfel, R., & Hoelscher, M. (2020). Transmission of 2019-nCoV Infection from an Asymptomatic Contact in Germany. The New England Journal of Medicine, 382(10), 970–971. https://doi.org/10.1056/NEJMc2001468
Solanki, D. Y. B., & Jain, S. M. (2010). Immunomodulatory activity of Ayurvedic plant Aparajita (Clitoria ternatea L.) in Male Albino Rats. Global Journal of Science Frontier Research, 10(3). https://journalofscience.org/index.php/GJSFR/article/view/19
Sugiyono. (2008). Metode penelitian pendidikan: (Pendekatan kuantitatif, kualitatif dan R & D). Alfabeta.
Swathi, K. P., Jayaram, S., Sugumar, D., & Rymbai, E. (2021). Evaluation of anti-inflammatory and anti-arthritic property of ethanolic extract of Clitoria ternatea. Chinese Herbal Medicines, 13(2), 243–249. https://doi.org/10.1016/j.chmed.2020.11.004
Taur, D. J., & Patil, R. Y. (2011). Evaluation of antiasthmatic activity of Clitoria ternatea L. roots. Journal of Ethnopharmacology, 136(2), 374–376. https://doi.org/10.1016/j.jep.2011.04.064
Wang, D., Hu, B., Hu, C., Zhu, F., Liu, X., Zhang, J., Wang, B., Xiang, H., Cheng, Z., Xiong, Y., Zhao, Y., Li, Y., Wang, X., & Peng, Z. (2020). Clinical Characteristics of 138 Hospitalized Patients With 2019 Novel Coronavirus-Infected Pneumonia in Wuhan, China. JAMA, 323(11), 1061–1069. https://doi.org/10.1001/jama.2020.1585
Yunitasari, N., & Na’imah, J. (2024). Sebuah Ulasan: Pemanfaatan Ekstrak Bunga Telang (Clitoria ternatea) di Bidang Obat dan Makanan. Muhammadiyah Journal of Nutrition and Food Science (MJNF), 5(2), 92–102. https://doi.org/10.24853/mjnf.5.2.92-102
Zhou, P., Yang, X.-L., Wang, X.-G., Hu, B., Zhang, L., Zhang, W., Si, H.-R., Zhu, Y., Li, B., Huang, C.-L., Chen, H.-D., Chen, J., Luo, Y., Guo, H., Jiang, R.-D., Liu, M.-Q., Chen, Y., Shen, X.-R., Wang, X., … Shi, Z.-L. (2020). Addendum: A pneumonia outbreak associated with a new coronavirus of probable bat origin. Nature, 588(7836), E6. https://doi.org/10.1038/s41586-020-2951-z
