Aktivitas Farmakologi Daun Kelor (Moringa oleifera) Sebagai Antiinflamasi (Pharmacological Activity of Moringa Leaves (Moringa oleifera) as an Anti-Inflammatory)
Pharmacological Activity of Moringa Leaves (Moringa oleifera) as an Anti-Inflammatory
Keywords:
Daun Kelor, Mekanisme, Antiinflamasi, Moringa Leaves, Mechanism, Antiinflamatory
Abstract
Daun kelor (Moringa oleifera) telah lama dikenal sebagai obat tradisional di masyarakat. Daun kelor memiliki banyak aktivitas farmakologi salah satunya sebagai antiinflamasi. Penelitian mengenai aktivitas antiinflamasi daun kelor sudah banyak dilakukan, baik secara in vitro maupun in vivo. Terdapat beberapa mekanisme antiinflamasi daun kelor diantaranya penghambatan sintesis prostaglandin, menekan sitokin pro inflamasi, penghambatan denaturasi protein. Tinjauan pustaka ini bertujuan untuk mengevaluasi secara komprehensif bukti penelitian terkini mengenai mekanisme kerja antiinflamasi daun kelor. Pencarian literatur menggunakan database nasional dan internasional seperti pubmed, google scholar, scopus dan lain sebagainya. Uji in vivo menunjukkan potensi daun kelor untuk dikembangkan menjadi sediaan farmasi bahkan dapat dikembangkan untuk dilakukan pengujian klinis kepada manusia.
References
Andersone, A., Janceva, S., Lauberte, L., Ramata?Stunda, A., Nikolajeva, V., Zaharova, N., Rieksts, G., & ????????, ?. (2023). Anti-Inflammatory, Anti-Bacterial, and Anti-Fungal Activity of Oligomeric Proanthocyanidins and Extracts Obtained from Lignocellulosic Agricultural Waste. Molecules, 28(2), 863. https://doi.org/10.3390/molecules28020863
Anwar, I., Parawansah., Yamin., Malina, R., & Fitri, A. (2024). Penentuan Kadar Fenolik, Flavonoid dan Uji Aktivitas Antiinflamasi Daun Kelor (Moringa oleifera) Terhadap Penghambatan Denaturasi Protein. Jurnal Ilmu Kefarmasian, 2(2), 110-123. https://hojps.uho.ac.id/index.php/journal
Assaye, M.A., Leo, M.D., Volterrani, D., Tesfay, H., Debebe, E., & Gebre, S.G. (2025). Phytochemical Profiling, Antioxidant and Antiinflamatory Potential of Methanolic Extract of Moringa oleifera (L.) Lam and Moringa stenopetala (Bak.) Cufod. Leaves Grown in Arba Minch, Ethiopia. Royal Society of Chemistry, 15(1), 43818-43829. https://pubs.rsc.org/en/content/articlepdf/2025/ra/d5ra05914c
Darwin, E., Elvira.D., & Elfi, E.F. (2021). Imunologi dan Infeksi. Padang: Andalas University Press.
Febrianto, V., Bulan, S., & Lesmana, D. (2022). Effect of Black Cumin Extract (Nigella sativa Linn.) on Closure Time of Incision Wound in Swiss Webster Mice. E-GIGI, 10(1), 109. https://doi.org/10.35790/eg.v10i1.39156
Fratiwi, N., Saranani, S., Agastia. G., & Isrul, M. (2022). Aktivitas Antiinflamasi Ekstrak Etanol Daun Kirinyuh (Chromolaena odorata L.) dan Pengaruhnya Terhadap Kadar Interleukin 6 (IL-6) Pada Tikus Jantan Galur Wistar. Jurnal Pharmacia Mandala Waluya, 1(2), 54-67. https://doi.org/10.54883/jpmw.v1i2.13
Gultom, E.D., & Marbun, N. (2021). Uji Aktivitas Inflamasi Ekstrak Etanol Daun Kelor (Moringa oleifera L.) Terhadap Tikus Putih Jantan Galur Wistar. Jurnal Pionir, 7(1), 295-301. https://doi.org/10.36294/pionir.v7i1.2780
Husien, H.M., Peng, W., Essa, M.O.A., Adam, S.Y., Rehman, S.U., Ali, R., Saleh, A.A., Wang, M., & Li, J. (2024). The Antiiflammatory Properties of Polysaccharides Extracted form Moringa oleifera Leaves in IEC6 Cells Stimulated With Lippopolysaccharide In Vitro. Animals, 14(23), 1-15. https://doi.org/10.3390/ani14233508
Iswantini, D., Tuwalaid, B., & Trivadila, T. (2021). The Potency of Legetan warak (Adenostemma lavenia) and Kersen Leaf (Muntingia calabura) Extract as a Candidate for Chronic Obstructive Pulmonary Disease (COPD) Herbal Medicine. Advances in Social Science, Education and Humanities Research/Advances in Social Science, Education and Humanities Research, 576(1), 447-452. https://doi.org/10.2991/assehr.k.210909.097
Kurniawati, E., Wibowo, F. S., & Rusmeilina, R. (2021). Aktivitas Penangkapan Radikal Bebas Pada Kombinasi Ekstrak Etanol Daun Mangga (Mangifera indica L.) dan Daun Sirsak (Annona muricata L.). Cendekia Journal of Pharmacy, 5(1), 92. https://doi.org/10.31596/cjp.v5i1.125
Lara, E.H., Miranda, J.R., Manrique, S.A., Lopez, C.D., Villalva, M., Jaime, L., Santoyo, S., & Sanchez, C.E.M. (2024). In Vitro Antioxidant, Anti-Inflamatory Activity and Bioaccessibility of Ethanolic Extracts from Mexican Moringa oleifera Leaf. Foods, 13(17), 1-17. https://doi.org/10.3390/foods13172709
Mulyani, T., Setyahadi, S., & Wibowo, A.E. (2023). Uji Aktivitas Antiinflamasi Kombinasi Ekstrak Daun Torbangun dan Ekstrak Daun Kelor dengan Metode Penghambatan Denaturasi Protein. Jurnal Farmasi Indonesia, 20(01), 26-32. https://doi.org/10.30595/pharmacy.v0i0.14246
Musyaropah, R., & Cahyanto, T. (2025). Studi Pemanfaatan Tanaman Kelor (Moringa oleifera) Sebagai Pengobatan Tradisional di Kampung Cibeas Desa Cintaraja Kecamatan Singaparna Kabupaten Tasikmalaya. Jurnal Kajian Ilmu Pertanian dan Perkebunan, 2(1), 44-54. https://doi.org/10.62951/flora.v2i1.213
Norhikami, & Fadhilah, A. (2024). Uji Efektivitas Antiinflamasi Ekstrak Etanol Daun Kelor (Moringa oleifera L.) pada Tikus Jantan Galur Wistar. Usadha: Journal of Pharmacy, 3(1), 114-122. https://jsr.ums.ac.id/ujp/article/view/321/226
Purnamasari, A., Zelviani, S., Sahara, S., & Fuadi, N. (2022). Analisis Nilai Absorbansi Kadar Flavonoid Tanaman Herbal Menggunakan Spektrofotometer Uv-Vis. Teknosains Media Informasi Sains Dan Teknologi, 16(1), 57. https://doi.org/10.24252/teknosains.v16i1.24185
Rindita, R., Efendi, K., & Armelia, T. D. (2020). Uji Teratogenitas Ekstrak Etanol 70% Daun Kelor (Moringa oleifera Lam.) Terhadap Mencit Putih Bunting Hiperglikemia. Farmasains Jurnal Ilmiah Ilmu Kefarmasian, 7(2), 39. https://doi.org/10.22236/farmasains.v7i2.5618
Robby, O., Gloria, F., & Saptawati, T. (2022). Pengaruh Variasi Konsentrasi Ekstrak Daun Kelor (Moringa oleifera Lamk) Terhadap Efek Antiinflamasi Sediaan Emulgel. Jurnal Penelitian Kesehatan Suara Forikes, 12(2), 444-452. http://dx.doi.org/10.33846/sf13231
Rohani, S. (2021). Isolation and Characterization of Wound Healing Compounds from Chloroform Extract of Binahong Leaves (Anredera cordifolia (Ten.) Steenis). MAGNA MEDICA Berkala Ilmiah Kedokteran Dan Kesehatan, 8(1), 40. https://doi.org/10.26714/magnamed.8.1.2021.40-59
Saleem, A., Saleem, M., & Akhtar, M.F. (2020). Antioxidant, Antiinflamatory an Antiarthritic Potential of Moringa oleifera Lam: An Ethnomedicinal Plant of Moringaceae Family. South Africa Journal of Botany, 128 (1), 246-256. https://doi.org/10.1016/j.sajb.2019.11.023
Septiani, S. I., Mayasari, D., & Prasetya, F. (2021). Kajian Literatur Tanaman Sirih Merah, Binahong, Dan Pegagan Sebagai Penyembuh Luka Insisi. Proceeding of Mulawarman Pharmaceuticals Conferences, 14, 398. https://doi.org/10.25026/mpc.v14i1.596
Shofi, Muh., & Putri, M. P. (2020). Training on making cendol starch using blue natural dyes extracted from telang flower essence. Journal of Community Service and Empowerment, 1(1), 1-4. https://doi.org/10.22219/jcse.v1i1.11514
Simorangkir, D., Hutagalung, J., & Tarigan, P. (2020). Uji Antivitas Inflamasi Ekstrak Etanol Daun Kelor (Moringa Oleifera L.) terhadap Tikus Putih Jantan (galur Wistar). Jurnal Penelitian Farmasi Herbal, 2(2), 38-43. https://doi.org/10.36656/jpfh.v2i2.236
Sofyanita, E. N., Bangkit, H. A., & Afriansya, R. (2021). Hubungan Jumlah Eritrosit dan Hitung Jenis Leukosit pada Masyarakat dengan Paparan Polutan Tinggi di Desa Tambak Mulyo Kota Semarang. Borneo Journal of Medical Laboratory Technology, 3(2), 217. https://doi.org/10.33084/bjmlt.v3i2.2230
Widiatmaja, D. T., Mufida, D. C., & Febianti, Z. (2021). Pengaruh Pemberian Imunisasi Intranasal Epitope Protein RrgB 255-270 Streptococcus pneumoniae Terhadap Kadar IL-4. Sriwijaya Journal Of Medicine, 4(1), 67. https://doi.org/10.32539/sjm.v4i1.155
Xie, B., & Li, X.Y. (2019). Inflammatory Mediators Causing Cutaneous Chronic Itch in Some Diseases Via Transient Receptor Potential Channel Subfamily V Member 1 and Subfamily A Member 1. Journal of Dermatology, 46(3), 177-185. https://doi.org/10.1016/j.indcrop.2018.09.026
Anwar, I., Parawansah., Yamin., Malina, R., & Fitri, A. (2024). Penentuan Kadar Fenolik, Flavonoid dan Uji Aktivitas Antiinflamasi Daun Kelor (Moringa oleifera) Terhadap Penghambatan Denaturasi Protein. Jurnal Ilmu Kefarmasian, 2(2), 110-123. https://hojps.uho.ac.id/index.php/journal
Assaye, M.A., Leo, M.D., Volterrani, D., Tesfay, H., Debebe, E., & Gebre, S.G. (2025). Phytochemical Profiling, Antioxidant and Antiinflamatory Potential of Methanolic Extract of Moringa oleifera (L.) Lam and Moringa stenopetala (Bak.) Cufod. Leaves Grown in Arba Minch, Ethiopia. Royal Society of Chemistry, 15(1), 43818-43829. https://pubs.rsc.org/en/content/articlepdf/2025/ra/d5ra05914c
Darwin, E., Elvira.D., & Elfi, E.F. (2021). Imunologi dan Infeksi. Padang: Andalas University Press.
Febrianto, V., Bulan, S., & Lesmana, D. (2022). Effect of Black Cumin Extract (Nigella sativa Linn.) on Closure Time of Incision Wound in Swiss Webster Mice. E-GIGI, 10(1), 109. https://doi.org/10.35790/eg.v10i1.39156
Fratiwi, N., Saranani, S., Agastia. G., & Isrul, M. (2022). Aktivitas Antiinflamasi Ekstrak Etanol Daun Kirinyuh (Chromolaena odorata L.) dan Pengaruhnya Terhadap Kadar Interleukin 6 (IL-6) Pada Tikus Jantan Galur Wistar. Jurnal Pharmacia Mandala Waluya, 1(2), 54-67. https://doi.org/10.54883/jpmw.v1i2.13
Gultom, E.D., & Marbun, N. (2021). Uji Aktivitas Inflamasi Ekstrak Etanol Daun Kelor (Moringa oleifera L.) Terhadap Tikus Putih Jantan Galur Wistar. Jurnal Pionir, 7(1), 295-301. https://doi.org/10.36294/pionir.v7i1.2780
Husien, H.M., Peng, W., Essa, M.O.A., Adam, S.Y., Rehman, S.U., Ali, R., Saleh, A.A., Wang, M., & Li, J. (2024). The Antiiflammatory Properties of Polysaccharides Extracted form Moringa oleifera Leaves in IEC6 Cells Stimulated With Lippopolysaccharide In Vitro. Animals, 14(23), 1-15. https://doi.org/10.3390/ani14233508
Iswantini, D., Tuwalaid, B., & Trivadila, T. (2021). The Potency of Legetan warak (Adenostemma lavenia) and Kersen Leaf (Muntingia calabura) Extract as a Candidate for Chronic Obstructive Pulmonary Disease (COPD) Herbal Medicine. Advances in Social Science, Education and Humanities Research/Advances in Social Science, Education and Humanities Research, 576(1), 447-452. https://doi.org/10.2991/assehr.k.210909.097
Kurniawati, E., Wibowo, F. S., & Rusmeilina, R. (2021). Aktivitas Penangkapan Radikal Bebas Pada Kombinasi Ekstrak Etanol Daun Mangga (Mangifera indica L.) dan Daun Sirsak (Annona muricata L.). Cendekia Journal of Pharmacy, 5(1), 92. https://doi.org/10.31596/cjp.v5i1.125
Lara, E.H., Miranda, J.R., Manrique, S.A., Lopez, C.D., Villalva, M., Jaime, L., Santoyo, S., & Sanchez, C.E.M. (2024). In Vitro Antioxidant, Anti-Inflamatory Activity and Bioaccessibility of Ethanolic Extracts from Mexican Moringa oleifera Leaf. Foods, 13(17), 1-17. https://doi.org/10.3390/foods13172709
Mulyani, T., Setyahadi, S., & Wibowo, A.E. (2023). Uji Aktivitas Antiinflamasi Kombinasi Ekstrak Daun Torbangun dan Ekstrak Daun Kelor dengan Metode Penghambatan Denaturasi Protein. Jurnal Farmasi Indonesia, 20(01), 26-32. https://doi.org/10.30595/pharmacy.v0i0.14246
Musyaropah, R., & Cahyanto, T. (2025). Studi Pemanfaatan Tanaman Kelor (Moringa oleifera) Sebagai Pengobatan Tradisional di Kampung Cibeas Desa Cintaraja Kecamatan Singaparna Kabupaten Tasikmalaya. Jurnal Kajian Ilmu Pertanian dan Perkebunan, 2(1), 44-54. https://doi.org/10.62951/flora.v2i1.213
Norhikami, & Fadhilah, A. (2024). Uji Efektivitas Antiinflamasi Ekstrak Etanol Daun Kelor (Moringa oleifera L.) pada Tikus Jantan Galur Wistar. Usadha: Journal of Pharmacy, 3(1), 114-122. https://jsr.ums.ac.id/ujp/article/view/321/226
Purnamasari, A., Zelviani, S., Sahara, S., & Fuadi, N. (2022). Analisis Nilai Absorbansi Kadar Flavonoid Tanaman Herbal Menggunakan Spektrofotometer Uv-Vis. Teknosains Media Informasi Sains Dan Teknologi, 16(1), 57. https://doi.org/10.24252/teknosains.v16i1.24185
Rindita, R., Efendi, K., & Armelia, T. D. (2020). Uji Teratogenitas Ekstrak Etanol 70% Daun Kelor (Moringa oleifera Lam.) Terhadap Mencit Putih Bunting Hiperglikemia. Farmasains Jurnal Ilmiah Ilmu Kefarmasian, 7(2), 39. https://doi.org/10.22236/farmasains.v7i2.5618
Robby, O., Gloria, F., & Saptawati, T. (2022). Pengaruh Variasi Konsentrasi Ekstrak Daun Kelor (Moringa oleifera Lamk) Terhadap Efek Antiinflamasi Sediaan Emulgel. Jurnal Penelitian Kesehatan Suara Forikes, 12(2), 444-452. http://dx.doi.org/10.33846/sf13231
Rohani, S. (2021). Isolation and Characterization of Wound Healing Compounds from Chloroform Extract of Binahong Leaves (Anredera cordifolia (Ten.) Steenis). MAGNA MEDICA Berkala Ilmiah Kedokteran Dan Kesehatan, 8(1), 40. https://doi.org/10.26714/magnamed.8.1.2021.40-59
Saleem, A., Saleem, M., & Akhtar, M.F. (2020). Antioxidant, Antiinflamatory an Antiarthritic Potential of Moringa oleifera Lam: An Ethnomedicinal Plant of Moringaceae Family. South Africa Journal of Botany, 128 (1), 246-256. https://doi.org/10.1016/j.sajb.2019.11.023
Septiani, S. I., Mayasari, D., & Prasetya, F. (2021). Kajian Literatur Tanaman Sirih Merah, Binahong, Dan Pegagan Sebagai Penyembuh Luka Insisi. Proceeding of Mulawarman Pharmaceuticals Conferences, 14, 398. https://doi.org/10.25026/mpc.v14i1.596
Shofi, Muh., & Putri, M. P. (2020). Training on making cendol starch using blue natural dyes extracted from telang flower essence. Journal of Community Service and Empowerment, 1(1), 1-4. https://doi.org/10.22219/jcse.v1i1.11514
Simorangkir, D., Hutagalung, J., & Tarigan, P. (2020). Uji Antivitas Inflamasi Ekstrak Etanol Daun Kelor (Moringa Oleifera L.) terhadap Tikus Putih Jantan (galur Wistar). Jurnal Penelitian Farmasi Herbal, 2(2), 38-43. https://doi.org/10.36656/jpfh.v2i2.236
Sofyanita, E. N., Bangkit, H. A., & Afriansya, R. (2021). Hubungan Jumlah Eritrosit dan Hitung Jenis Leukosit pada Masyarakat dengan Paparan Polutan Tinggi di Desa Tambak Mulyo Kota Semarang. Borneo Journal of Medical Laboratory Technology, 3(2), 217. https://doi.org/10.33084/bjmlt.v3i2.2230
Widiatmaja, D. T., Mufida, D. C., & Febianti, Z. (2021). Pengaruh Pemberian Imunisasi Intranasal Epitope Protein RrgB 255-270 Streptococcus pneumoniae Terhadap Kadar IL-4. Sriwijaya Journal Of Medicine, 4(1), 67. https://doi.org/10.32539/sjm.v4i1.155
Xie, B., & Li, X.Y. (2019). Inflammatory Mediators Causing Cutaneous Chronic Itch in Some Diseases Via Transient Receptor Potential Channel Subfamily V Member 1 and Subfamily A Member 1. Journal of Dermatology, 46(3), 177-185. https://doi.org/10.1016/j.indcrop.2018.09.026
