Efektivitas Induksi Propofol dan Inhalasi Sevofluran terhadap Kestabilan Hemodinamik pada Pasien Craniotomy: Systematic Literature Review
Effectiveness of Propofol Induction and Sevoflurane Inhalation on Hemodynamic Stability in Craniotomy Patients: A Systematic Literature Review
Keywords:
Propofol, Sevofluran, Craniotomy, Hemodinamik, Anestesi, Propofol, Sevoflurane, Craniotomy, Hemodynamics, Anesthesia
Abstract
Penelitian ini bertujuan untuk menganalisis perbandingan efek hemodinamik antara propofol dan sevofluran pada pasien craniotomy melalui pendekatan systematic literature review (SLR). Pencarian literatur dilakukan pada Google Scholar, ScienceDirect, dan PubMed dengan pedoman Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA). Sebanyak 10 studi dianalisis menggunakan Joanna Briggs Institute (JBI) Critical Appraisal Tools. Hasil menunjukkan bahwa sevofluran cenderung memberikan kestabilan hemodinamik yang lebih baik dengan fluktuasi tekanan darah yang lebih ringan, sedangkan propofol lebih sering menyebabkan hipotensi meskipun memiliki keunggulan dalam menurunkan tekanan intrakranial. Kombinasi kedua agen menunjukkan hasil yang lebih optimal dalam beberapa studi. Kesimpulannya, sevofluran lebih stabil secara hemodinamik, namun pemilihan agen anestesi harus disesuaikan dengan kondisi klinis pasien untuk mencapai keamanan optimal selama tindakan craniotomy.
References
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Dhande, S. G., Thombare, B. H., & Magar, J. S. (2020). Comparison of hemodynamic changes during induction of anesthesia with sevoflurane and propofol in adult patients: A randomized clinical study. Journal of Medical Science and Clinical Research, 8(2), 652-658. https://dx.doi.org/10.18535/jmscr/v8i2.113
Dutta, A., Sethi, N., Singh, M., & Gupta, P. (2023). Comparative evaluation of hemodynamic stability during induction with sevoflurane versus propofol: A focus on blood pressure and heart rate variability. Indian Journal of Anaesthesia and Analgesia, 10(3), 245-252.
Eka, A., Sari, P., Suandika, M., & Firdaus, E. K. (2024). 2024 Madani?: Jurnal Ilmiah Multidisipline Pengaruh Pemberian Anestesi Induksi Sevofluran Dengan Penurunan Hemodinamik Pada Pasien General Anestesi di RSUD Labuha Halmahera Selatan 2024 Madani?: Jurnal Ilmiah Multidisipline. 2(9), 373–379.
Ghanem, M. A., Elemam, K., Mousa, S. A., & Youssef, M. Y. (2021). Cerebral Oxygenation and Metabolism in Patients Undergoing Clipping of Cerebral Aneurysm: A Comparative Study between Propofol-based total intravenous anesthesia and Sevoflurane-based inhalational anesthesia. Egyptian Journal of Anaesthesia, 37(1), 135–144. https://doi.org/10.1080/11101849.2021.1900524
Jonathan, J., Wijaya, K. M., Johansyah, T. K. P., Sari, F. P., Satrio, K., & Jobul, I. C. (2024). Propofol-based Anesthesia versus Volatile Anesthesia on Brain Relaxation in Neurosurgery: A Meta-analysis of Randomized Controlled Trials. Neurologico Spinale Medico Chirurgico, 7(1), 6–16. https://doi.org/10.4103/nsmc.nsmc_23_23
Ling, Q., et al. (2025). The effect of sevoflurane combined with propofol anesthesia on hemodynamic and pain in elderly patients undergoing radical surgery for malignant tumors. Journal of Geriatric Oncology and Clinical Research, 12(2), 310-322.
Liu, C. C., Chen, I. W., Liu, P. H., Wu, J. Y., Liu, T. H., Huang, P. Y., Yu, C. H., Fu, P. H., & Hung, K. C. (2024). Efficacy of propofol-based anesthesia against risk of brain swelling during craniotomy: A meta-analysis of randomized controlled studies. Journal of Clinical Anesthesia, 92, 111306. https://doi.org/10.1016/J.JCLINANE.2023.111306
Makmur. (2022). PENERAPAN POSISI HEAD UP 300 PADA PASIEN POST CRANIOTOMY MENINGIOMA TERHADAP PENURUNAN TEKANAN INTRAKRANIAL. 6, 2437–2446.
Patel, L. P., Rathva, C. S., & Solanki, V. R. (2022). A comparative study of awakening characteristics after propofol based total intravenous anaesthesia and sevoflurane based volatile induction and maintenance anaesthesia in short surgical procedure. 9(3), 310–315.
Pratama, B. D., Gofari, M. S., & Juddin, M. (2023). Analisis Perubahan Frekuensi Nadi Pada Pasien Intra Anestesi Dengan Penggunaan Sevofluran. 1.
Pratama, R. A., Laksono, B. H., & Fatoni, A. Z. (2020). Manajemen Nyeri Akut Pasca-Kraniotomi. Journal of Anaesthesia and Pain, 1(3), 28–38. https://doi.org/10.21776/ub.jap.2020.001.03.04
Qi, L., Yi, X., Li, C., & Li, Y. (2025). The Effect of Sevoflurane Combined with Propofol Anesthesia on Hemodynamics and Pain in Elderly Patients Undergoing Radical Surgery for Malignant Tumors. April, 2197–2206.
Robba, C. (2022). Effects of propofol or sevoflurane anesthesia induction on hemodynamics in patients undergoing fiberoptic intubation for cervical spine surgery: A randomized, controlled, clinical trial.
Robba, C., Qeva, E., Borsellino, B., Aloisio, S., Tosti, G., & Bilotta, F. (2019). Effects of propofol or sevoflurane anesthesia induction on hemodynamics in patients undergoing fiberoptic intubation for cervical spine surgery: A randomized, controlled, clinical trial. Journal of Anaesthesiology Clinical Pharmacology, 33(2), 215–220. https://doi.org/10.4103/0970-9185.209733
Singh, H., & Shekhawat, K. K. (2025). Comparative Study of Propofol and Sevoflurane for Induction of Anesthesia in Day Care Surgery. Journal of Neonatal Surgery, 14(4), 460–470. https://doi.org/10.52783/jns.v14.1819
Sjøen, R., & others. (2023). Hemodynamic effects of a low versus a high dose of propofol during induction of anesthesia: A randomized trial. Acta Anaesthesiologica Scandinavica, 67(1), 45–52. https://doi.org/10.1111/aas.14293
Somawi, A. P., Rehatta, N. M., Kriswidyatomo, P., Santoso, K. H., Hamzah, & Lestari, P. (2024). Effect of Propofol TIVA Compared Sevoflurane Inhalation Anesthesia on Triglyceride Levels After Elective Craniotomy Surgery. Pharmacognosy Journal , 16(3), 597–601. https://doi.org/10.5530/pj.2024.16.93
Vi?iusBane1, G., Rugyt?1, D., Macas1, A., & Tamašauskas2, Arimantas, Stankevi?ius3, E. (2020). The effects of sevoflurane and propofol on cerebral hemodynamics during intracranial tumors surgery under monitoring the depth of anesthesia - PubMed. https://pubmed.ncbi.nlm.nih.gov/21467832/
Wan Hassan, W. M. N., Mohd Nasir, Y., Mohamad Zaini, R. H., & Wan Muhd Shukeri, W. F. (2019). Target-controlled Infusion Propofol Versus Sevoflurane Anaesthesia for Emergency Traumatic Brain Surgery: Comparison of the Outcomes. The Malaysian Journal of Medical Sciences?: MJMS, 24(5), 73–82. https://doi.org/10.21315/MJMS2017.24.5.8
Zhou, Z., Ying, M., Zhao, R., & Cruz., J. N. (2021). Efficacy and safety of sevoflurane vs propofol in combination with remifentanil for anesthesia maintenance during craniotomy: A meta-analysis. Medicine, 100(51). https://doi.org/10.1097/MD.0000000000028400
